Control of morphology and functions of Surfactant Aggregate by RNA

• Project/Area Number: 20750102
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Functional materials chemistry
• Research Institution: Kanazawa University
• Principal Investigator: OHTA Akio Kanazawa University, 物質化学系, 准教授 (10324104)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 膜 / 組織体 / 界面活性剤 / RNA

Research Abstract

Nucleic acid is a one of the anionic polymers and interacts with some cationic surfactants and as a result a complex, which is called lipoplex, is formed. In this study, we focused the complex of RNA and cationic surfactant, and investigated the aggregation behaviors by several techniques. It was found that the aggregation was controlled by pH or surfactant concentration for the RNA-cationic surfactant system as well as the DNA system.

Research Products

• [Journal Article] Effect of Functional Groups on Incorporation Behavior of Amino Acid-Type Surfactant into Phospholipid Vesicle Membrane (2009)
  • Author(s): OHTA A, et.al (他4名 1番目)
  • Journal Title: Journal of Oleo Science 58 Pages: 607-615
  • NAID: 130000126071
  • Peer Reviewed
• [Journal Article] Effect of Functional Groups on Incorporation Behavior of Amino Acid-Type Surfactant into Phospholipid Vesicle Membrane (2009)
  • Author(s): Akio OHTA, et al.
  • Journal Title: Journal of Oleo Science 58 Pages: 607-615
  • NAID: 130000126071
  • Peer Reviewed
• [Presentation] カルニチン型両性界面活性剤のDNAとの複合体形成 (2010)
  • Author(s): 竹本廉、太田明雄、浅川毅
  • Organizer: 日本化学会近畿支部平成22年度北陸地区講演会と研究発表会
  • Place of Presentation: 富山大学(富山)
  • Year and Date: 2010-11-19
• [Presentation] カルニチン型両性界面活性剤のDNAとの複合体形成 (2010)
  • Author(s): 竹本廉, 太田明雄
  • Organizer: 日本化学会近畿支部平成22年度北陸地区講演会と研究発表会
  • Place of Presentation: 富山大学(富山県)
  • Year and Date: 2010-11-19
• [Presentation] Adsorption and Aggregation Behaviors of Nucleic Acids with pH-Sensitive Surfactant (2010)
  • Author(s): 嶋直人、太田明雄、浅川毅
  • Organizer: NCSS 2010
  • Place of Presentation: 幕張メッセ(千葉)
  • Year and Date: 2010-09-21
• [Presentation] Adsorption and Aggregation Behaviors of Nucleic Acids with pH-Sensitive Surfactant (2010)
  • Author(s): 嶋直人, 太田明雄
  • Organizer: NCSS 2010
  • Place of Presentation: 幕張メッセ(千葉県)
  • Year and Date: 2010-09-21
• [Presentation] リン脂質ベシクルへのアミノ酸型界面活性剤の作用 (2009)
  • Author(s): 太田明雄
  • Organizer: 第62回コロイドおよび界面化学討論会
  • Place of Presentation: 岡山理科大学(岡山)
  • Year and Date: 2009-09-18
• [Presentation] リン脂質ベシクルへのアミノ酸型界面活性剤の作用 (2009)
  • Author(s): 太田明雄
  • Organizer: 第62回コロイドおよび界面化学討論会
  • Place of Presentation: 岡山理科大学(岡山県)
  • Year and Date: 2009-09-18
• [Presentation] 核酸への界面活性剤の吸着と複合体形成 (2009)
  • Author(s): 嶋直人、太田明雄、浅川毅
  • Organizer: 第48回日本油化学会年会
  • Place of Presentation: 名古屋工業大学(愛知)
  • Year and Date: 2009-09-10
• [Presentation] 核酸への界面活性剤の吸着と複合体形成 (2009)
  • Author(s): 嶋直人 太田明雄
  • Organizer: 第48回日本油化学会年会
  • Place of Presentation: 名古屋工業大学(愛知県)
  • Year and Date: 2009-09-10
• [Presentation] ジェミニ型界面活性剤を用いたtRNAとの会合制御 (2008)
  • Author(s): 龍見岳典、桶川のどか、太田明雄、浅川毅、牧輝弥
  • Organizer: 第61回コロイドおよび界面化学討論会
  • Place of Presentation: 九州大学(福岡)
  • Year and Date: 2008-09-09
• [Presentation] ジェミニ型界面活性剤を用いたtRNAとの会合制御 (2008)
  • Author(s): 龍見岳典, 太田明雄
  • Organizer: 第61回コロイドおよび界面化学討論会
  • Place of Presentation: 九州大学
  • Year and Date: 2008-09-09
• [Presentation] 四級アンモニウム塩型カチオン界面活性剤を用いたtRNAとの複合体形成における添加塩効果 (2008)
  • Author(s): 龍見岳典、太田明雄、浅川毅、牧輝弥
  • Organizer: 第61回コロイドおよび界面化学討論会
  • Place of Presentation: 九州大学(福岡)
  • Year and Date: 2008-09-07
• [Presentation] 四級アンモニウム塩型カチオン界面活性剤を用いたtRNAとの複合体形成における添加塩効果 (2008)
  • Author(s): 龍見岳典, 太田明雄
  • Organizer: 第61回コロイドおよび界面化学討論会
  • Place of Presentation: 九州大学
  • Year and Date: 2008-09-07