• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Analysis of splicing variant of p53-inducible phosphatase PPM1D on carcinogenesis

Research Project

Project/Area Number 20770095
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Functional biochemistry
Research InstitutionHokkaido University

Principal Investigator

CHUMAN Yoshiro  Hokkaido University, 大学院・理学研究院, 助教 (40372263)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsホスファターゼ / スプライシング / PPM1D / p53 / がん / 酵素
Research Abstract

PPM1D is a PPM1 type protein phosphatase and is induced in response to DNA damage. In our current study, we identify and characterize an alternative splicing variant (denoted PPM1D430) of human PPM1D at both the mRNA and protein level. PPM1D430 comprises the common 420 residues of the known PPM1D protein (PPM1D605) and contains a stretch of PPM1D430-specific 10 amino acids. Semi-quantitative RT-PCR analysis revealed that PPM1D430 mRNA is also induced in response to the genotoxic stress in a p53-dependent manner. In vitro phosphatase analysis and PPM1D430-specific RNA interference analysis further indicated that PPM1D430 can dephosphorylate Ser15 of human p53 both in vitro and in vivo. On the other hand, expression profiling of this gene by RT-PCR analysis of a human tissue cDNA panel revealed that PPM1D430 is expressed exclusively in testes and in leukocytes whereas PPM1D605 is ubiquitous. In addition, PPM1D430 shows a different subcellular localization pattern and protein stability when compared with PPM1D605 under some conditions. Our current findings thus suggest that PPM1D430 may exert specific functions in immune response and/or spermatogenesis.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (91 results)

All 2011 2010 2009 2008

All Journal Article (46 results) (of which Peer Reviewed: 46 results) Presentation (43 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Phosphatase assay for multi-phosphorylated substrates using phosphatase specific-motif antibody2011

    • Author(s)
      Chuman, Y., Iizuka, K., Honda, T., Onoue, H., Shimohigashi, Y., Sakaguchi, K.
    • Journal Title

      J.Biochem. in press

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] sFRP-1 binds via its netrin-related motif to the N-module of thrombospondin-1 and blocks thrombospondin-1 stimulation of MDA-MB-231 breast carcinoma cell adhesion and migration.2011

    • Author(s)
      Martin-Manso, G., Calzada, M.J., Chuman, Y., Sipes, J.M., Xavier, C.P., Wolf, V., Kuznetsova, S.A., Rubin, J.S., Roberts, D.D.
    • Journal Title

      Arch.Biochem.Biophys. 509(2)

      Pages: 147-156

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Probing phenylalanine environments in oligomeric structures with pentafluorophenylalanine and cyclohexylalanine.2011

    • Author(s)
      Nomura, T., Kamada, R., Ito, I., Sakamoto, K., Chuman, Y., Ishimori, K., Shimohigashi, Y., Sakaguchi, K.
    • Journal Title

      Biopolymers 95(6)

      Pages: 410-419

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] sFRP-1 binds via its netrin-related motif to the N-module of thrombospondin-1 and blocks thrombospondin-1 stimulation of MDA-MB-231 breast carcinoma cell adhesion and migration.2011

    • Author(s)
      Martin-Manso, et al.
    • Journal Title

      Arch.Biochem.Biophys.

      Volume: 509 Pages: 147-156

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Probing phenylalanine environments in oligomeric structures with pentafluorophenylalanine and cyclohexylalanine.2011

    • Author(s)
      Nomura, et al.
    • Journal Title

      Biopolymers

      Volume: 95 Pages: 410-419

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhancement of transcriptional activity of mutant p53 tumor suppressor protein through stabilization of tetramer formation by calix[6]arene derivatives2010

    • Author(s)
      Kamada, R., Yoshino, W., Nomura, T., Chuman, Y., Imagawa, T., Suzuki, T., Sakaguchi, K.
    • Journal Title

      Bioorg.Med.Chem Lett. 20(15)

      Pages: 4412-4415

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Drastic Effects on Fibril Formation of Amyloid-beta Peptides by the Addition of Amino Acid Residue Units to the Termini2010

    • Author(s)
      Asanomi, Y., Kobayashi, Y, Sakai, H., Masuda, T., Chen, X., Chuman, Y., Uosaki, K., Sakaguchi, K.
    • Journal Title

      Protein Pept.Lett. 17(4)

      Pages: 458-463

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fluoroalkene Modification of Mercaptoacetamide-based Histone Deacetylase Inhibitors2010

    • Author(s)
      Osada, S., Sano, S., Ueyama, M., Chuman, Y., Kodama, H., Sakaguchi, K.
    • Journal Title

      Bioorg.Med.Chem. 18(2)

      Pages: 605-611

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of Two Novel and Potent Inhibitors Specific for p53-Inducible Protein Phosphatase PPM1D.2010

    • Author(s)
      Yagi, H., Chuman, Y., Sakaguchi, K.
    • Journal Title

      Peptide Science 2009

      Pages: 455-456

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Biomineralization Activity of Multivalent minTBP-1 Peptide Mediated by p53 Tetramerization Domain.2010

    • Author(s)
      Sakaguchi, T., Kamada, R., Nomura, T., Chuman, Y., Imagawa, T., Sakaguchi, K.
    • Journal Title

      Peptide Science 2009

      Pages: 411-412

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of Probed-SCAP Directed at Thiol Groups.2010

    • Author(s)
      Watanabe, K., Sakai, H., Chen, X., Chuman, Y, Sakaguchi, K.
    • Journal Title

      Peptide Science 2009

      Pages: 407-408

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of p53 by Introducing Tetramerization Domain Peptide Fused with Polyvalent Cationic Sequence into Cells.2010

    • Author(s)
      Kamada, R., Oshima, S., Chuman, Y., Imagawa, T., Sakaguchi, K.
    • Journal Title

      Peptide Science 2009

      Pages: 319-320

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Enhancement of transcriptional activity of mutant p53 tumor suppressor protein through stabilization of tetramer formation by calix[6]arene derivatives2010

    • Author(s)
      Kamada, et al.
    • Journal Title

      Bioorg.Med.Chem Lett.

      Volume: 20 Pages: 4412-4415

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Drastic Effects on Fibril Formation of Amyloid-beta Peptides by the Addition of Amino Acid Residue Units to the Termini2010

    • Author(s)
      Asanomi, et al.
    • Journal Title

      Protein Pept.Lett.

      Volume: 17 Pages: 458-463

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fluoroalkene Modification of Mercaptoacetamide-based Histone Deacetylase Inhibitors2010

    • Author(s)
      Osada, et al.
    • Journal Title

      Bioorg.Med.Chem.

      Volume: 18 Pages: 605-611

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of Two Novel and Potent Inhibitors Specific for p53-Inducible Protein Phosphatase PPM1D2010

    • Author(s)
      Yagi, et al.
    • Journal Title

      Peptide Science

      Volume: 2009 Pages: 455-456

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biomineralization Activity of Multivalent minTBP-1 Peptide Mediated by p53 Tetramerization Domain2010

    • Author(s)
      Sakaguchi, et al.
    • Journal Title

      Peptide Science

      Volume: 2009 Pages: 411-412

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of Probed-SCAP Directed at Thiol Groups2010

    • Author(s)
      Watanabe, et al.
    • Journal Title

      Peptide Science

      Volume: 2009 Pages: 407-408

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of p53 by Introducing Tetramerization Domain Peptide Fused with Polyvalent Cationic Sequence into Cells2010

    • Author(s)
      Kamada, et al.
    • Journal Title

      Peptide Science

      Volume: 2009 Pages: 319-320

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Drastic Effects on Fibril Formation of Amyloid-beta Peptides by the Addition of Amino Acid Residue Units to the Termini2010

    • Author(s)
      Asanomi, et al.
    • Journal Title

      Protein Pept.Lett. 17(4)

      Pages: 458-463

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fluoroalkene Modification of Mercaptoacetamide-based Histone Deacetylase Inhibitors2010

    • Author(s)
      Osada, et al.
    • Journal Title

      Bioorg.Med.Chem. 18

      Pages: 605-611

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of Two Novel and Potent Inhibitors Specificfor p53-Inducible Protein Phosphatase PPM1D2010

    • Author(s)
      Yagi, et al.
    • Journal Title

      Peptide Science 2009

      Pages: 455-456

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biomineralization Activity of Multivalent minTBP-1 Peptide Mediated by p53 Tetramerization Domain2010

    • Author(s)
      Sakaguchi, et al.
    • Journal Title

      Peptide Science 2009

      Pages: 411-412

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of Probed-SCAP Directed at Thiol Groups2010

    • Author(s)
      Watanabe, et al.
    • Journal Title

      Peptide Science 2009

      Pages: 407-408

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of p53 by Introducing Tetramerization Domain Peptide Fused with Polyvalent Cationic Sequence into Cells2010

    • Author(s)
      Kamada, et al.
    • Journal Title

      Peptide Science 2009

      Pages: 319-320

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PPM1D430, a Novel Alternative Splicing Variant of the Human PPM1D, can Dephosphorylate p53 and Exhibits Specific Tissue Expression2009

    • Author(s)
      Chuman, Y., Kurihashi, W., Mizukami, Y., Nashimoto, T., Yagi, H., Sakaguchi, K.
    • Journal Title

      J.Biochem. 145(1)

      Pages: 1-12

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of tumor-associated mutations in the p53 tetramerization domain on oligomerization state and transcriptional activity.2009

    • Author(s)
      Kamada, R., Terai, T., Nomura, T., Chuman, Y, Imagawa, T., Sakaguchi, K.
    • Journal Title

      Adv.Exp.Med.Biol. 611

      Pages: 567-568

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Oxidation of methionine residue at hydrophobic core destabilizes p53 tetrameric structure2009

    • Author(s)
      Nomura, T., Kamada, R., Ito, I., Chuman, Y, Shimohigashi, Y, Sakaguchi, K.
    • Journal Title

      Biopolymers 91(1)

      Pages: 78-84

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] PPM1D430, a Novel Alternative Splicing Variant of the Human PPM1D.2009

    • Author(s)
      Chuman, Y., Kurihashi, W., Mizukami, Y., Nashimoto, T., Yagi, H., Sakaguchi, K.
    • Journal Title

      Peptide Science 2008

      Pages: 531-532

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Thermal Stability of p53 Tetramerization Domain Pe4ptides Derived from Various Species.2009

    • Author(s)
      Nomura, T., Kamada, R., Chuman, Y., Sakaguchi, K.
    • Journal Title

      Peptide Science 2008

      Pages: 35-36

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of Novel Chemical Inhibitors for p53-Inducible Protein Phosphatase PPM1D.2009

    • Author(s)
      Yagi, H., Chuman, Y., Yoshimura, F., Tanino, K., Sakaguchi, K.
    • Journal Title

      Peptide Science 2008

      Pages: 385-386

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Extremely Long Nanofibrils of Functionalized Structure-Controlled-Amyloid Peptides Derived from Transthyretin.2009

    • Author(s)
      Sakai, H., Asanomi, Y., Kobayashi, Y., Chen, X., Chuman, Y., Masuda, T., Uosaki, K., Sakaguchi, K.
    • Journal Title

      Peptide Science 2008

      Pages: 465-466

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] PPM1D430, a Novel Alternative Splicing Variant of the Human PPM1D, can Dephosphorylate p53 and Exhibits Specific Tissue Expression2009

    • Author(s)
      Chuman, et al.
    • Journal Title

      J Biochem. 145

      Pages: 1-12

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PPM1D430, a Novel Alternative Splicing Variant of the Human PPM1D, can Dephosphorylate p53 and Exhibits Specific Tissue Expression2009

    • Author(s)
      Chuman et.al.
    • Journal Title

      J Biochem 145

      Pages: 1-12

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PPM1D430, a Novel Alternative Splicing Variant of the Human PPM1D2009

    • Author(s)
      Chuman et.al.
    • Journal Title

      Peptide Science 2008

      Pages: 531-532

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Thermal Stability of p53 Tetramerization Domain Peptides Derived from Various Species2009

    • Author(s)
      Nomura et.al.
    • Journal Title

      Peptide Science 2008

      Pages: 35-36

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of Novel Chemical Inkibitors for p53-lnducible Protein Phosphatase PPM1D2009

    • Author(s)
      Yagi et.al.
    • Journal Title

      Peptide Science 2008

      Pages: 385-386

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Extremely Long Nanofibrils of Functionalized Structure-Controlled-Amyloid Peptides Derived from Transthyretin2009

    • Author(s)
      Sakai et.al.
    • Journal Title

      Peptide Science 2008

      Pages: 465-466

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of the Active Site and a Unique Uncompetitive Inhibitor of the PPM1-type Protein Phosphatase PPM1D2008

    • Author(s)
      Chuman, Y., Yagi, H., Fukuda, T., Nomura, T., Matsukizono, M., Shimohigashi, Y., Sakaguchi K.
    • Journal Title

      Protein Pept.Lett. 15

      Pages: 938-948

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differential Recognition of Phosphorylated Transactivation Domains of p53 by Different p300 Domains2008

    • Author(s)
      Polley, S., Guha, S., Roy, N.S., Kar, S., Sakaguchi, K., Chuman, Y., Swaminathan, V., Roy, S.
    • Journal Title

      J.Mol.Biol. 376

      Pages: 8-12

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Correlation of Oligomeric Structure and Transcriptional Activity of p53 Mutants.2008

    • Author(s)
      Kamada, R, Terai, T., Nomura, T., Chuman, Y, Imagawa, T., Sakaguchi, K.
    • Journal Title

      Peptide Science 2007

      Pages: 69-70

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Screening of Peptides to Stabilize the p53 Tetramer Formation from Phage Displayed Library.2008

    • Author(s)
      Nomura, T., Kamada, R., Chuman, Y., Sakaguchi, K.
    • Journal Title

      Peptide Science 2007

      Pages: 315-316

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Correlation between Expression Level in E. coli and Stability of Oligomeric Structure of the p53 Tetramerization Domain.2008

    • Author(s)
      Miyazaki, H., Kamada, R., Nomura, T., Chuman, Y., Imagawa, T., Sakaguchi, K.
    • Journal Title

      Peptide Science 2007

      Pages: 317-318

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Structural Photomodulation of Peptides with Azobenzoate Derivative in Peptide Backbone.2008

    • Author(s)
      Kamada, R., Fukuda, K., Miyazaki, H., Nomura, T., Chuman, Y., Imagawa, T., Tanino, K., Sakaguchi, K.
    • Journal Title

      Peptide Science 2007

      Pages: 447-448

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Oxidation of methionine residue at hydrophobic core destabilizes p53 tetrameric structure2008

    • Author(s)
      Nomura et.al.
    • Journal Title

      Biopolymers 91

      Pages: 78-84

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of the Active Site and a Unique Uncompetitive Inhibitor of the PPM1-type Protein Phosphatase PPM1D2008

    • Author(s)
      Chuman et.al.
    • Journal Title

      Protein Pept. Lett 15

      Pages: 938-948

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Novel chemical inhibitors specific for p53-inducible protein phosphatase PPM1D2011

    • Author(s)
      Yagi Y.
    • Organizer
      Anaheim Convention Center, Anaheim, USA
    • Place of Presentation
      Anaheim Convention Center, Anaheim, USA
    • Year and Date
      2011-03-29
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 脱リン酸化酵素PPM1D阻害剤SPI-001の阻害様式と核小体形成に対する効果2011

    • Author(s)
      小境夕紀
    • Organizer
      日本化学会第91春季年会(2011)
    • Place of Presentation
      神奈川大学横浜キャンパス
    • Year and Date
      2011-03-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] Suppression of Breast Cancer Cells Proliferation by Novel Inhibitor for p53-Inducible Protein Phosphatase PPM1D2011

    • Author(s)
      Chuman Y.
    • Organizer
      1st International Symposium on Carcinogenic Spiral & 9th International Conference on Protein Phosphatase
    • Place of Presentation
      Tetsumon Memorial Hall, The University of Tokyo
    • Year and Date
      2011-02-01
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Novel small molecule inhibitors specific for p53-inducible protein phosphatase PPM1D2011

    • Author(s)
      Yagi H.
    • Organizer
      1st International Symposium on Carcinogenic Spiral & 9th International Conference on Protein Phosphatase
    • Place of Presentation
      Tetsumon Memorial Hall, The University of Tokyo
    • Year and Date
      2011-02-01
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Increase in number of nucleoli by protein phosphatase PPM1D overexpression2011

    • Author(s)
      Kozakai Y.
    • Organizer
      1st International Symposium on Carcinogenic Spiral & 9th International Conference on Protein Phosphatase
    • Place of Presentation
      Tetsumon Memorial Hall, The University of Tokyo
    • Year and Date
      2011-02-01
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] p53誘導性ホスファターゼPPMID阻害による乳がん細胞増殖抑制作用2010

    • Author(s)
      中馬吉郎
    • Organizer
      BMB2010第83回日本生化学会、第33回日本分子生物学会合同大会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2010-12-10
    • Related Report
      2010 Final Research Report
  • [Presentation] p53誘導性ホスファターゼPPMID特異的阻害剤SPI-001の相互作用2010

    • Author(s)
      八木寛陽
    • Organizer
      BMB2010第83回日本生化学会、第33回日本分子生物学会合同大会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2010-12-10
    • Related Report
      2010 Final Research Report
  • [Presentation] p53誘導性ホスファターゼPPM1D阻害による乳がん細胞増殖抑制作用2010

    • Author(s)
      中馬吉郎
    • Organizer
      BMB2010第83回日本生化学会、第33回日本分子生物学会合同大会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2010-12-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] p53誘導性ホスファターゼPPM1D特異的阻害剤SPI-001の相互作用2010

    • Author(s)
      八木寛陽
    • Organizer
      BMB2010第83回日本生化学会、第33回日本分子生物学会合同大会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2010-12-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] PPMID430, a Nove1 Alternative Splicing Variant of the Human PPM1D, can Dephosphorylate p53 and Exhibits Specific Tissue Expression2010

    • Author(s)
      中馬吉郎
    • Organizer
      BMB2010第83回日本生化学会第33回日本分子生物学会合同大会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2010-12-09
    • Related Report
      2010 Final Research Report
  • [Presentation] PPM1D430, a Novel Alternative Splicing Variant of the Human PPM1D, can Dephosphorylate p53 and Exhibits Specific Tissue Expression2010

    • Author(s)
      中馬吉郎
    • Organizer
      BMB2010第83回日本生化学会、第33回日本分子生物学会合同大会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2010-12-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] Dephosphorylation of Nucleolar Protein Nucleophosmin by Protein Phosphatase PPM1D2010

    • Author(s)
      Kozakai Y.
    • Organizer
      5th International Peptide Symposium in conjunction with 47th Japanese Peptide Symposium
    • Place of Presentation
      Kyoto International Conference Center
    • Year and Date
      2010-12-04
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Effect of Protein Phosphatase PPM1D on Nucleolus Formation2010

    • Author(s)
      Kozakai Y.
    • Organizer
      MPSA 2010
    • Place of Presentation
      Norrlands nation at Uppsala University in Uppsala, Sweden
    • Year and Date
      2010-08-25
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] p53誘導性ホスファターゼ特異的阻害剤の開発と細胞増殖抑制能2010

    • Author(s)
      中馬吉郎
    • Organizer
      日本化学会北海道支部2010年夏季研究発表会
    • Place of Presentation
      函館高専
    • Year and Date
      2010-07-24
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] p53誘導性ホスファターゼのスプライシングバリアントの同定と阻害剤開発2010

    • Author(s)
      中馬吉郎
    • Organizer
      第47回日本生化学会北海道支部例会(招待講演)
    • Place of Presentation
      北海道大学医学部第3講堂
    • Year and Date
      2010-07-23
    • Related Report
      2010 Final Research Report
  • [Presentation] p53誘導性ホスファターゼPPMID阻害剤における特定に配向する疎水性部位2010

    • Author(s)
      八木寛陽
    • Organizer
      第47回日本生化学会北海道支部例会
    • Place of Presentation
      北海道大学医学部第3講堂
    • Year and Date
      2010-07-23
    • Related Report
      2010 Final Research Report
  • [Presentation] PPMIDホスファターゼ過剰発現が核小体形成に及ぼす影響2010

    • Author(s)
      小境夕紀
    • Organizer
      第47回日本生化学会北海道支部例会
    • Place of Presentation
      北海道大学医学部第3講堂
    • Year and Date
      2010-07-23
    • Related Report
      2010 Final Research Report
  • [Presentation] p53誘導性ホスファターゼのスプライシングバリアントの同定と阻害剤開発2010

    • Author(s)
      中馬吉郎
    • Organizer
      第47回日本生化学会北海道支部例会
    • Place of Presentation
      北海道大学医学部第3講堂(招待講演)
    • Year and Date
      2010-07-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] p53誘導性ホスファターゼPPM1D阻害剤における特定に配向する疎水性部位2010

    • Author(s)
      八木寛陽
    • Organizer
      第47回日本化学会北海道支部例会
    • Place of Presentation
      北海道大学医学部第3講堂
    • Year and Date
      2010-07-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] PPM1Dホスファターゼ過剰発現が核小体形成に及ぼす影響2010

    • Author(s)
      小境夕紀
    • Organizer
      第47回日本生化学会北海道支部例会
    • Place of Presentation
      北海道大学医学部第3講堂
    • Year and Date
      2010-07-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] 脱リン酸化酵素PPMID阻害剤SPI-001の阻害様式と核小体形成に対する効果2010

    • Author(s)
      小境夕紀
    • Organizer
      日本化学会第91春季年会(2011)
    • Place of Presentation
      神奈川大学横浜キャンパス
    • Year and Date
      2010-03-29
    • Related Report
      2010 Final Research Report
  • [Presentation] p53誘導性ホスファターゼPPMIDの新規阻害剤2010

    • Author(s)
      梨本健紘
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山桃太郎アリーナ(岡山)
    • Year and Date
      2010-03-29
    • Related Report
      2010 Final Research Report
  • [Presentation] p53誘導性ホスファターゼPPM1Dの新規阻害剤2010

    • Author(s)
      梨本健紘
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山桃太郎アリーナ(岡山)
    • Year and Date
      2010-03-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] p53誘導性ホスファターゼPPMIDに対する新規阻害剤の開発2009

    • Author(s)
      中馬吉郎
    • Organizer
      第4回日本プロテインホスファターゼ研究会学術集会
    • Place of Presentation
      熊本大学(熊本)
    • Year and Date
      2009-11-13
    • Related Report
      2010 Final Research Report
  • [Presentation] p53誘導性ホスファターゼPPM1Dに対する新規阻害剤の開発2009

    • Author(s)
      中馬吉郎
    • Organizer
      第4回日本プロテインホスファターゼ研究会学術集会
    • Place of Presentation
      熊本大学(熊本)
    • Year and Date
      2009-11-13
    • Related Report
      2009 Annual Research Report
  • [Presentation] Characterization of Two Novel and Potent Inhibitors Specific for p53-Inducible Protein Phosphatase PPM1D2009

    • Author(s)
      Yagi H.
    • Organizer
      第46回ペプチド討論会
    • Place of Presentation
      北九州国際会議場(小倉・北九州)
    • Year and Date
      2009-11-04
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] p53誘導性ホスファターゼPPMIDの基質認識と阻害剤開発2009

    • Author(s)
      八木寛陽
    • Organizer
      第42回若手ペプチド夏の勉強会
    • Place of Presentation
      八王子セミナーハウス(東京・八王子)
    • Year and Date
      2009-08-02
    • Related Report
      2010 Final Research Report
  • [Presentation] p53誘導性ホスファターゼPPM1Dの基質認識と阻害剤開発2009

    • Author(s)
      八木寛陽
    • Organizer
      第42回 若手ペプチド夏の勉強会
    • Place of Presentation
      八王子セミナーハウス(東京・八王子)
    • Year and Date
      2009-08-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] p53誘導性ホスファターゼPPMIDに対するシリル基を持つ低分子阻害剤2009

    • Author(s)
      八木寛陽
    • Organizer
      日本生化学会北海道支部第46回例会
    • Place of Presentation
      旭川医科大学(旭川)
    • Year and Date
      2009-07-17
    • Related Report
      2010 Final Research Report
  • [Presentation] p53誘導性ホスファターゼPPM1Dに対するシリル基を持つ低分子阻害剤2009

    • Author(s)
      八木寛陽
    • Organizer
      日本生化学会北海道支部第46回例会
    • Place of Presentation
      旭川医科大学(旭川)
    • Year and Date
      2009-07-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] Identification and characterization of novel alternative splicing variant of p53-inducible protein phosphatase PPMID2008

    • Author(s)
      Kurihashi W.
    • Organizer
      第8回ホスファターゼカンファレンス
    • Place of Presentation
      前橋テルサ(群馬)
    • Year and Date
      2008-11-14
    • Related Report
      2010 Final Research Report
  • [Presentation] Identification and characterization of novel alternative splicing variant of p53-inducible protein phosphatase PPM1D2008

    • Author(s)
      Kurihashi W
    • Organizer
      第8回ホスファターゼカンファレンス
    • Place of Presentation
      前橋テルサ(群馬)
    • Year and Date
      2008-11-14
    • Related Report
      2008 Annual Research Report
  • [Presentation] ヒトPPMIDの選択的スプライシングバリアントPPMID4302008

    • Author(s)
      中馬吉郎
    • Organizer
      第45回ぺプチド討論会
    • Place of Presentation
      タワーホール船堀(東京都江戸川区)
    • Year and Date
      2008-10-31
    • Related Report
      2010 Final Research Report
  • [Presentation] Identification of novel chemical inhibitors for p53-inducible protein phosphatase PPMID2008

    • Author(s)
      八木寛陽
    • Organizer
      第45回ペプチド討論会
    • Place of Presentation
      タワーホール船堀(東京都江戸川区)
    • Year and Date
      2008-10-31
    • Related Report
      2010 Final Research Report
  • [Presentation] ヒトPPM1Dの選択的スプライシングバリアントPPM1D4302008

    • Author(s)
      中馬吉郎
    • Organizer
      第45回ペプチド討論会
    • Place of Presentation
      タワーホール船堀(東京都江戸川区)
    • Year and Date
      2008-10-31
    • Related Report
      2008 Annual Research Report
  • [Presentation] Identification of novel chemical inhibitors for p53-inducible protein phosphatase PPM1D2008

    • Author(s)
      八木寛陽
    • Organizer
      第45回ペプチド討論会
    • Place of Presentation
      タワーホール船堀(東京都江戸川区)
    • Year and Date
      2008-10-31
    • Related Report
      2008 Annual Research Report
  • [Presentation] An Alternative Splicing Variant of the PPM1 Protein Phosphatase PPMID2008

    • Author(s)
      Chuman Y.
    • Organizer
      MPSA2008
    • Place of Presentation
      北海道大学(札幌市)
    • Year and Date
      2008-08-26
    • Related Report
      2010 Final Research Report
  • [Presentation] Novel chemical inhibitors for p53-inducible protein phosphatase PPM1D2008

    • Author(s)
      Yagi H.
    • Organizer
      MPSA2008
    • Place of Presentation
      北海道大学(札幌市)
    • Year and Date
      2008-08-26
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] An Alternative Splicing Variant of the PPM1 Protein Phosnhatase PPM1D2008

    • Author(s)
      Chuman Y
    • Organizer
      MPSA2008
    • Place of Presentation
      北海道大学(札幌市)
    • Year and Date
      2008-08-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] リン酸化と脱リン酸化によるタンパク質制御機構~p53誘導性ホスファターゼPPMIDを中心にして~2008

    • Author(s)
      中馬吉郎
    • Organizer
      第41回若手ペプチド夏の勉強会
    • Place of Presentation
      プライムイン城陽(京都・城陽市)
    • Year and Date
      2008-08-05
    • Related Report
      2010 Final Research Report
  • [Presentation] リン酸化と脱リン酸化によるタンパク質制御機構〜p53誘導性ホスファターゼPPM1Dを中心にして〜2008

    • Author(s)
      中馬吉郎
    • Organizer
      第41回若手ペプチド夏の勉強会
    • Place of Presentation
      プライムイン城陽(京都・城陽市)
    • Year and Date
      2008-08-05
    • Related Report
      2008 Annual Research Report
  • [Presentation] 癌抑制タンパク質p53誘導性ホスファターゼのAlternativesplicing variant2008

    • Author(s)
      中馬吉郎
    • Organizer
      日本分子生物学会第8回春季シンポジゥム
    • Place of Presentation
      京王プラザホテル(札幌)
    • Year and Date
      2008-05-27
    • Related Report
      2010 Final Research Report
  • [Presentation] 癌抑制タンパク質p53誘導性ホスファターゼのAlternative splicing variant2008

    • Author(s)
      中馬吉郎
    • Organizer
      日本分子生物学会第8回春季シンポジウム
    • Place of Presentation
      京王プラザホテル(札幌)
    • Year and Date
      2008-05-27
    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] プロテインホスファターゼ阻害剤2008

    • Inventor(s)
      坂口和靖、谷野圭持、中馬吉郎、吉村文彦、八木寛陽
    • Industrial Property Rights Holder
      LCIP
    • Industrial Property Number
      2008-262646
    • Filing Date
      2008-10-09
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] プロテインボスファターゼ阻害剤2008

    • Inventor(s)
      坂口和靖他
    • Industrial Property Rights Holder
      北海道大学
    • Industrial Property Number
      2008-262646
    • Filing Date
      2008-10-09
    • Related Report
      2008 Annual Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi