Analysis of gene silencing mechanism by bacterial small RNA
| Project/Area Number |
20770137
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Molecular biology
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| Research Institution | Nagoya University |
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Principal Investigator |
MORITA Teppei Nagoya University, 薬学部・薬学科, 助手 (10444366)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 小分子RNA / mRNA抑制 / 転写後制御 / 大腸菌 / 低分子RNA / 遺伝子発現制御 |
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| Research Abstract |
SgrS sRNA acts by baseparing with ptsG mRNA, resulting in translation inhibition and degradation of ptsG mRNA. We showed that the base pairing between SgrS and ptsG mRNA is directly responsible for translational silencing mediated by SgrS. We also identified a minimal base-pairing region of SgrS required for translational repression of ptsG mRNA. These results contribute to understanding the molecular mechanism by which Hfq-dependent sRNA act in bacteria.
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Report
(3 results)
Research Products
(27 results)
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[Journal Article] The Plasmodium HU homolog, which binds the plastid DNA sequence-independent manner, is essential for the parasite's survival2009
Author(s)
Sasaki N, Hirai M, Maeda K, Yui R, Itoh K, Namiki S, Morita T, Hata M, Murakami-Murofushi K, Matsuoka H, Kita K, Sato S.
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Journal Title
FEBS lett. 583(9)
Pages: 1446-1450
Related Report
Peer Reviewed
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