Development of new cancer therapy to invasive cancer targeting hyaluronic acid matrix remodeling and CD44 ectodomain cleavage
| Project/Area Number |
20770161
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cell biology
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| Research Institution | Keio University |
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Principal Investigator |
NAGANO Osamu Keio University, 医学部, 助教 (30404346)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 癌 / 遺伝子 / 細胞・組織 / CD44 / HAS / 癌細胞浸潤 |
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| Research Abstract |
We developed the method for the evaluation of CD44 cleavage of matrix-invading cancer cells. By using this method, we screened chemical compounds and found several inhibitors for CD44 cleavage and matrix invasion. Furthermore, we established the functional role of CD44 in gastric tumorigenesis.
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Report
(3 results)
Research Products
(9 results)
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[Journal Article] Tumor necrosis factor-alpha regulates transforming growth factor-beta-dependent epithelial-mesenchymal transition by promoting hyaluronan-CD44-moesin interaction.2010
Author(s)
Takahashi E, Nagano O, Ishimoto T, Yae T, Suzuki Y, Shinoda T, Nakamura S, Niwa S, Ikeda S, Koga H, Tanihara H, Saya H.
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Journal Title
J Biol Chem. 285
Pages: 4060-4073
Related Report
Peer Reviewed
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[Journal Article] CD44+ slow-cycling tumor cell expansion is triggered by cooperative actions of Wnt and prostaglandin E2 in gastric tumorigenesis.2010
Author(s)
Ishimoto T, Oshima H, Oshima M, Kai K, Torii R, Masuko T, Baba H, Saya H, Nagano O.
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Journal Title
Ishimoto T, Oshima H, Oshima M, Kai K, Torii R, Masuko T, Baba H, Saya H and Nagano O. Cancer Sci. 101
Pages: 673-678
Related Report
Peer Reviewed
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