Development of new cancer therapy to invasive cancer targeting hyaluronic acid matrix remodeling and CD44 ectodomain cleavage

• Project/Area Number: 20770161
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Cell biology
• Research Institution: Keio University
• Principal Investigator: NAGANO Osamu Keio University, 医学部, 助教 (30404346)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 癌 / 遺伝子 / 細胞・組織 / CD44 / HAS / 癌細胞浸潤

Research Abstract

We developed the method for the evaluation of CD44 cleavage of matrix-invading cancer cells. By using this method, we screened chemical compounds and found several inhibitors for CD44 cleavage and matrix invasion. Furthermore, we established the functional role of CD44 in gastric tumorigenesis.

Research Products

• [Journal Article] Tumor necrosis factor-alpha regulates transforming growth factor-beta-dependent epithelial-mesenchymal transition by promoting hyaluronan-CD44-moesin interaction. (2010)
  • Author(s): Takahashi E, Nagano O, Ishimoto T, Yae T, Suzuki Y, Shinoda T, Nakamura S, Niwa S, Ikeda S, Koga H, Tanihara H, Saya H.
  • Journal Title: J Biol Chem. 285 Pages: 4060-4073
  • Peer Reviewed
• [Journal Article] CD44+ slow-cycling tumor cell expansion is triggered by cooperative actions of Wnt and prostaglandin E2 in gastric tumorigenesis. (2010)
  • Author(s): Ishimoto T, Oshima H, Oshima M, Kai K, Torii R, Masuko T, Baba H, Saya H, Nagano O.
  • Journal Title: Ishimoto T, Oshima H, Oshima M, Kai K, Torii R, Masuko T, Baba H, Saya H and Nagano O. Cancer Sci. 101 Pages: 673-678
  • Peer Reviewed
• [Journal Article] EGFR and ErbB2 are functionally coupled to CD44 and regulate shedding, internalization and motogenic effect of CD44 (2008)
  • Author(s): Palyi-Krekk, et.al.
  • Journal Title: Cancer Lett 263 Pages: 231-242
  • Peer Reviewed
• [Journal Article] Rb depletion results in deregulation of E-cadherin and induction of cellular phenotypic changes that are characteristic of the epithelial-to-mesenchymal transition (2008)
  • Author(s): Arima, et.al.
  • Journal Title: Cancer Res 68 Pages: 5104-5112
  • Peer Reviewed
• [Presentation] 胃癌幹細胞様細胞の拡大および腫瘍進展におけるCD44の役割 (2010)
  • Author(s): 永野修、石本崇胤、佐谷秀行
  • Organizer: 第9回日本再生医療学会総会
  • Place of Presentation: 広島国際会議場
  • Year and Date: 2010-03-19
• [Presentation] 胃癌幹細胞様細胞の拡大および腫瘍進展におけるCD44の役割 (2010)
  • Author(s): 永野修、石本崇胤、佐谷秀行
  • Organizer: 第9回日本医療学会総会
  • Place of Presentation: 広島国際会議場
  • Year and Date: 2010-03-19
• [Presentation] 胃癌幹細胞様細胞の拡大および腫瘍進展におけるCD44の役割 (2009)
  • Author(s): 永野修
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 第98回日本病理学会総会、国立京都国際会館
  • Year and Date: 2009-05-01
• [Presentation] 胃癌幹細胞様細胞の拡大および腫瘍進展におけるCD44の役割 (2009)
  • Author(s): 永野修、石本崇胤、甲斐千晴、佐谷秀行
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2009-05-01
• [Presentation] 胃癌幹細胞増殖および腫瘍進展におけるCD44の役割 (2008)
  • Author(s): 永野修
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2008-10-28