Meiotic transition of germline stem cells and molecular regulation of homologous chromosome recombination
| Project/Area Number |
20770177
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Developmental biology
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| Research Institution | Kyoto University |
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Principal Investigator |
CHUMA Shinichiro Kyoto University, 再生医科学研究所, 助教 (20378889)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 生殖細胞 / 減数分裂 / 発生 / ゲノム / 相同組換え |
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| Research Abstract |
In this research project, we developed a novel culture system in which an established germline stem cell line derived from mouse spermatogonia can be synchronously induced to enter into meiotic prophase in vitro. This culture system enabled detailed molecular and biochemical analyses on mammalian meiosis such as inductive and inhibitory signaling pathways, their crosstalk and chromatin dynamics during homologous chromosome recombination.
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Report
(3 results)
Research Products
(13 results)
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[Journal Article] The TDRD9-MIWI2 complex is essential for piRNA-mediated retrotransposon silencing in the mouse male germline2009
Author(s)
Shoji M, Tanaka T, Hosokawa M, Reuter M, Stark A, Kato Y, Kondoh G, Okawa K, Chujo T, Suzuki T, Hata K, Martin SL, Noce T, Kuramochi-Miyagawa S, Nakano T, Sasaki H, Pillai RS, Nakatsuji N, Chuma S
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Journal Title
Dev Cell. 17
Pages: 775-787
Related Report
Peer Reviewed
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