Characterization of a novel modulator of Wnt signaling

• Project/Area Number: 20770179
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Developmental biology
• Research Institution: Hiroshima University
• Principal Investigator: SATO Akira Hiroshima University, 大学院・医歯薬学総合研究科, 助教 (70464302)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: シグナル伝達 / 発生・分化 / Wnt / Dvl / 脳・神経

Research Abstract

Wnt signaling pathway play important roles in many developmental processes in animals. I identified a new modulator of the Wnt/β-catenin pathway, named DBP, to negatively control this pathway via binding to Dvl. In addition, it was found that Wnt5a, a member of 19 Wnts, inhibits Wnt3a-dependent activation of the Wnt/β-catenin pathway by competing with Wnt3a for binding to the Wnt receptor Frizzled 2.

Research Products

• [Journal Article] Wnt5a signaling is involved in the aggressiveness of prostate cancer and expression of metalloproteinase (2010)
  • Author(s): Yamamoto H, Oue N, Sato A, Hasegawa Y, Yamamoto H, Matsubara A, Yasui W, Kikuchi A
  • Journal Title: Oncogene (In press)
  • Peer Reviewed
• [Journal Article] Wnt5a regulates distinct signaing pathways by binding to Frizzled2 (2010)
  • Author(s): Sato A, Yamamoto H, Sakane H, Koyama H, Kikuchi A
  • Journal Title: EMBO J 29 Pages: 41-54
  • Peer Reviewed
• [Journal Article] Wnt5a regulates distinct signaling pathways by binding to Frizzled2 (2010)
  • Author(s): Sato A, Yamamoto H, Sakane H, Koyarna H, Kikuchi A
  • Journal Title: EMBO J. 29巻1号 Pages: 41-54
  • Peer Reviewed
• [Journal Article] Selective activation mechanisms of Wnt signaling pathways (2009)
  • Author(s): Kikuchi A, Yamamoto H, Sato A
  • Journal Title: Trends Cell Biol 19 Pages: 119-29
  • Peer Reviewed
• [Journal Article] Selective activation mechanisms of Wnt signaling pathways (2009)
  • Author(s): Kikuchi A
  • Journal Title: Trends Cell Biol. 19 Pages: 119-129
  • Peer Reviewed
• [Journal Article] Wntによるβカテニン非依存性経路の活性化とその異常による病態 (2009)
  • Author(s): 菊池章
  • Journal Title: 蛋白質核酸酵素(PNE) 54 Pages: 1-10
  • Peer Reviewed
• [Presentation] Wnt5a regulates distinct signaling pathways by binding to Frizzled 2 (2009)
  • Author(s): 佐藤朗
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2009-12-09
• [Presentation] Wnt5a regulates distinct signaling pathways by binding to Frizzled2 (2009)
  • Author(s): 佐藤朗
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2009-12-09
• [Presentation] Wnt5aによるWnt3a- β-catenin経路の新規抑制機構の解析 (2008)
  • Author(s): 佐藤朗
  • Organizer: 第31回日本分子生物学会年会
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2008-12-11
• [Presentation] Wnt5aによるWnt3a-β-catenin経路の新規抑制機構の解析 (2008)
  • Author(s): 佐藤朗
  • Organizer: 弟31回日本分子生物学会年会
  • Place of Presentation: 神戸市
  • Year and Date: 2008-12-11