Characterization of a novel modulator of Wnt signaling
| Project/Area Number |
20770179
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Developmental biology
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| Research Institution | Hiroshima University |
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Principal Investigator |
SATO Akira Hiroshima University, 大学院・医歯薬学総合研究科, 助教 (70464302)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | シグナル伝達 / 発生・分化 / Wnt / Dvl / 脳・神経 |
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| Research Abstract |
Wnt signaling pathway play important roles in many developmental processes in animals. I identified a new modulator of the Wnt/β-catenin pathway, named DBP, to negatively control this pathway via binding to Dvl. In addition, it was found that Wnt5a, a member of 19 Wnts, inhibits Wnt3a-dependent activation of the Wnt/β-catenin pathway by competing with Wnt3a for binding to the Wnt receptor Frizzled 2.
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Report
(3 results)
Research Products
(10 results)
