| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
The expression of polychlorinated biphenyls degradation genes in a PCB degrader, Rhodococcus jostii RHA1, is activated in the existence of biphenyl. This activation is repressed in the existence of intermediate metabolites which appear in the downstream pathway. In this study. we revealed that catechol is the metabolite which causes this repression. By making the metabolism flux from catechol smoothly, a PCB degrader which gives the constant degradation activity can be constructed.
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