| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Research Abstract |
The AS2/LOB-domain protein, ASYMMETRIC LEAVES2 (AS2), and nucleolar localized histone deacetylases, HDT1/2, are involved in the determination of leaf shape in Arabidopsis. However, the molecular mechanisms underlying these phenomena are largely unknown. I investigated the functions of missense mutants of AS2 and HDT1/2 proteins. The missense mutants of AS2 revealed that the in vivo function of AS2 required the formation of hetero-tetramer including the N-termini of AS1 through the AS2/LOB-domain. The AS1-AS2 complex localizes the speckled bodies adjacent nucleoli, in which HDT1/2 localize. The analyses of HDT1/2 provide the further understanding of the mechanism underlying the synergistic interaction between the AS1-AS2 complex and HDT1/2.
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