| Project/Area Number |
20780241
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied molecular and cellular biology
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| Research Institution | Nara Institute of Science and Technology |
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Principal Investigator |
MATSUI Takaaki Nara Institute of Science and Technology, バイオサイエンス研究科, 助教 (60403333)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 発生 / 体節 / Hes / FGF / Hes7 / Sprouty4 / 位置情報 / 空間情報 / 形態形成 / オシレーション |
|---|
| Research Abstract |
During vertebrate development, somites are generated by periodic segmentation. In this study, we investigated the relationship between segmentation clock (Hes) and special information (FGF). We show that Sprouty4 oscillates in mouse presomitic mesoderm, and that clock-dependent modulation of FGF signal activity acts as a determinant for future somite boundaries.
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