Measurement/observation of special information during somitogenesis

• Project/Area Number: 20780241
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Applied molecular and cellular biology
• Research Institution: Nara Institute of Science and Technology
• Principal Investigator: MATSUI Takaaki Nara Institute of Science and Technology, バイオサイエンス研究科, 助教 (60403333)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
• Keywords: 発生 / 体節 / Hes / FGF / Hes7 / Sprouty4 / 位置情報 / 空間情報 / 形態形成 / オシレーション

Research Abstract

During vertebrate development, somites are generated by periodic segmentation. In this study, we investigated the relationship between segmentation clock (Hes) and special information (FGF). We show that Sprouty4 oscillates in mouse presomitic mesoderm, and that clock-dependent modulation of FGF signal activity acts as a determinant for future somite boundaries.

Research Products

• [Journal Article] Sprouty4, an FGF inhibitor, displays cyclic gene expression under the control of the Notch segmentation clock in the mouse (2009)
  • Author(s): Shinichi Hayashi, Taiju Shimoda, Masato Nakajima, Yuki Tsukada, Yuichi Sakumura, J. Kim Dale, Miguel Maroto, Kenji Kohno, Takaaki Matsui, Yasumasa Bessho
  • Journal Title: PSM PLoS One 4
  • Peer Reviewed
• [Journal Article] Sprouty4, an FGF inhibitor, displays cyclic gene expression under the control of the Notch segmentation clock in the mouse PSM (2009)
  • Author(s): S.Hayashi, et al.
  • Journal Title: PLoS One 4
  • Peer Reviewed
• [Presentation] Self-amplification of the Fgf signal regulates functional cell clustering during zebrafish embryo development (2009)
  • Author(s): T.Matsui, et al.
  • Organizer: 第32回日本分子生物学会年会(英語口頭)
  • Place of Presentation: 横浜(パシフィコ横浜)
  • Year and Date: 2009-12-11
• [Presentation] Fgfシグナルの自己増幅システムを利用した細胞のクラスタリング機構 (2009)
  • Author(s): 松井貴輝, ら
  • Organizer: 第15回小型魚類研究会(口頭)
  • Place of Presentation: 名古屋大学
  • Year and Date: 2009-09-12
• [Presentation] 体節形成過程におけるFGFシグナルの役割 (2009)
  • Author(s): 秋山隆一郎, ら
  • Organizer: 第15回小型魚類研究会(ポスター)
  • Place of Presentation: 名古屋大学
  • Year and Date: 2009-09-12
• [Presentation] Self-amplification of the Fgf signal regulates functional cell clustering during zebrafish embryo development (2009)
  • Author(s): Takaaki Matsui, Siripong Thitamadee, Tomoko Murata, Hisaya Kakinuma, Takuji Nabetani, Yoshio Hirabayashi, Yoshikazu Hirate, Hitoshi Okamoto, Yasumasa Bessho
  • Organizer: ワークショップ&ポスター第32回日本分子生物学会年会
  • Place of Presentation: 横浜(パシフィコ横浜)((英語口頭))
• [Presentation] Fgfシグナルの自己増幅システムを利用した細胞のクラスタリング機構 (2009)
  • Author(s): 松井貴輝, Siripong Thitamadee, 村田朋子, 柿沼久哉, 鍋谷卓司, 平林義雄, 平手良和, 岡本仁, 別所康全
  • Organizer: 第15回小型魚類研究会
  • Place of Presentation: 名古屋大(口頭)
• [Presentation] 体節形成過程におけるFGFシグナルの役割 (2009)
  • Author(s): 秋山隆太郎, 松井貴輝, 別所康全
  • Organizer: 第15回小型魚類研究会
  • Place of Presentation: 名古屋大(ポスター)
• [Presentation] ビブラフィッシュの左右軸形成におけるcanopy1の役割 (2008)
  • Author(s): 松井貴輝, 村田朋子, 平手良和, 岡本仁, 別所康全
  • Organizer: 小型魚類研究会
  • Place of Presentation: 岡崎
  • Year and Date: 2008-09-20