| Project/Area Number |
20790019
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Chemical pharmacy
|
|---|
| Research Institution | Teikyo University |
|---|
Principal Investigator |
SAWADA Daisuke Teikyo University, 薬学部, 講師 (00338691)
|
|---|
| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Keywords | ビタミンD / プレビタミンD / 骨粗鬆症 / 活性型ビタミンD_3 / ビタミンD受容体 / プレビタミンD_3 / tachsterol / 14-エピ-19-ノルプレビタミンD_3 / 骨粗鬆症治療薬 / オステオカルシン転写活性 / genomic action / nongenomic action / 14-エピービタミンD_3 |
|---|
| Research Abstract |
In this project, I have synthesized and stably isolated the 14-epi-previtamin D3 analogs as new seco-steroidal compounds by synthetic chemical modification. Using these new analogs, I evaluated their biological properties, and have found a new lead compound for osteoporosis drug. Also, I was able to have preliminary results for the evaluation of their nongenomic action. By the removal of 19-methyl group, I have discovered the isomerization from previtamin D3 to tachysterol skeleton, which could be a new drug candidate.
|
