Synthesis of new seco-steroidal compounds, their use for steroidal biological evaluation, and development of new drug candidates
Project/Area Number |
20790019
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Chemical pharmacy
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Research Institution | Teikyo University |
Principal Investigator |
SAWADA Daisuke Teikyo University, 薬学部, 講師 (00338691)
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Project Period (FY) |
2008 – 2009
|
Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | ビタミンD / プレビタミンD / 骨粗鬆症 / 活性型ビタミンD_3 / ビタミンD受容体 / プレビタミンD_3 / tachsterol / 14-エピ-19-ノルプレビタミンD_3 / 骨粗鬆症治療薬 / オステオカルシン転写活性 / genomic action / nongenomic action / 14-エピービタミンD_3 |
Research Abstract |
In this project, I have synthesized and stably isolated the 14-epi-previtamin D3 analogs as new seco-steroidal compounds by synthetic chemical modification. Using these new analogs, I evaluated their biological properties, and have found a new lead compound for osteoporosis drug. Also, I was able to have preliminary results for the evaluation of their nongenomic action. By the removal of 19-methyl group, I have discovered the isomerization from previtamin D3 to tachysterol skeleton, which could be a new drug candidate.
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Report
(3 results)
Research Products
(74 results)
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[Journal Article] Synthesis of 2α-substituted-14-epi-previtamin D3 and its genomic activity2009
Author(s)
Daisuke Sawada, Tomoyuki Katayama, Yuya Tsukuda, Nozomi Saito, Masashi Takano, Hiroshi Saito, Ken-ichiro Takagi, Eiji Ochiai, Seiichi Ishizuka, Kazuya Takenouchi, Atsushi Kittaka
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Journal Title
Bioorg. Med. Chem. Lett. 19
Pages: 5397-5400
Related Report
Peer Reviewed
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[Journal Article] Synthesis and Biological Activities of 14-epi-MART-10 and 14-epi-MART-11: Implications for Cancer and Osteoporosis Treatment2009
Author(s)
Atsushi Kittaka, Hideki Hara, MasashiTakano, Daisuke Sawada, Midori A.Arai, Kenichiro Takagi, TakayukiChida, Yoshifumi Harada, HiroshiSaito, Kazuya Takenouchi, SeiichiIshizuka, Keiko Hayashi, ShinichiIkushiro, Toshiyuki Sakaki, TakayukiSugiura, Tai C. Chen
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Journal Title
Anticancer Res. 29
Pages: 3563-3569
Related Report
Peer Reviewed
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[Journal Article] Vitamin D Hormone: Structural Refinement of the Seco-Steroidal Skeleton and the Nuclear Receptor Mediated Biological Activity2008
Author(s)
Atsushi Kittaka, Daisuke Sawada, Masashi Takano, Nozomi Saito, Tomoyuki Katayama, Kanako Shindo, Yuya Tsukuda, Shinobu Honzawa, Midori A. Arai, Hiroshi Saito, Ken-ichiro Takagi, Kazuya Takenouchi, Seiichi Ishizuka, Toshiyuki Sakaki, Tai C. Chen
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Journal Title
Anticancer Res. 28
Pages: 1611-1612
Related Report
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