Development of bioactive peptide derivative and dry powder inhalation system for treatment of COPD

• Project/Area Number: 20790103
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Drug development chemistry
• Research Institution: University of Shizuoka
• Principal Investigator: ONOUE Satomi University of Shizuoka, 薬学部, 准教授 (00457912)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 慢性閉塞性肺疾患 / 血管作働性腸管ペプチド / 粉末吸入製剤

Research Abstract

We developed some VIP derivative with improved stability, and dry powder inhaler system of VIP derivative was also designed for inhalation therapy. Intratracheal administration of VIP-based respirable powder led to significant attenuation of inflammatory events in COPD model rats.

Research Products

• [Journal Article] Development of inhalable nanocrystalline solid dispersionof tranilast for airway inflammatorydiseases (2011)
  • Author(s): Satomi Onoue, ほか
  • Journal Title: Journal of Pharmaceutical Sciences 100巻 Pages: 622-633
  • Peer Reviewed
• [Journal Article] Development of inhalable nanocrystalline solid dispersion of tranilast for airway inflammatory diseases. (2011)
  • Author(s): Satomi Onoue, ほか
  • Journal Title: Journal of Pharmaceutical Sciences Volume: 100 Pages: 622-633
  • Peer Reviewed
• [Journal Article] Novel crystalline solid dispersion of tranilastwith high photostability and improved oralbioavailability (2010)
  • Author(s): Yohei Kawabata, Satomi Onoue, ほか
  • Journal Title: European Journal of Pharmaceutical Sciences 39巻 Pages: 256-262
  • Peer Reviewed
• [Journal Article] Formulation designand photochemical studies on nanocrystalsolid dispersion of curcumin with improvedoral bioavailability (2010)
  • Author(s): Satomi Onoue, ほか
  • Journal Title: Journal of Pharmaceutical Sciences 99巻 Pages: 1871-1881
  • Peer Reviewed
• [Journal Article] Inhalable powder formulation of a stabilized vasoactive intestinal peptide (VIP) derivarive : anti-inflammatory effect in experimental asthmatic rats (2010)
  • Author(s): Shingen Misaka, Satomi Onoue, ほか
  • Journal Title: Peptides 31巻 Pages: 72-78
  • Peer Reviewed
• [Journal Article] Novel crystalline solid dispersion of tranilast with high photostability and improved oral bioavailability. (2010)
  • Author(s): Yohei Kawabata, Satomi Onoue, ほか
  • Journal Title: European Journal of Pharmaceutical Sciences Volume: 39 Pages: 256-262
  • Peer Reviewed
• [Journal Article] Formulation design and photochemical studies on nanocrystal solid dispersion of curcumin with improved oral bioavailability. (2010)
  • Author(s): Satomi Onoue, ほか
  • Journal Title: Journal of Pharmaceutical Sciences Volume: 99 Pages: 1871-1881
  • Peer Reviewed
• [Journal Article] Inhalable powder formulation of a stabilized vasoactive intestinal peptide (VIP) derivative : anti-inflammatory effect in experimental asthmatic rats. (2010)
  • Author(s): Shingen Misaka, Satomi Onoue, ほか
  • Journal Title: Peptides Volume: 31 Pages: 72-78
  • Peer Reviewed
• [Journal Article] Novel dry powder inhaler formulation of glucagon with addition of citric acid for enhanced pulmonary delivery (2009)
  • Author(s): Satomi Onoue, ほか
  • Journal Title: International Journal of Pharmaceutics 382巻 Pages: 144-150
  • Peer Reviewed
• [Journal Article] Physicochemical and pharmacological characterization of novel vasoactive intestinal peptide derivatives with improved stability. (2009)
  • Author(s): Satomi Onoue, ほか
  • Journal Title: European Journal of Pharmaceutics and Biopharmaceutics 73巻 Pages: 95-101
  • Peer Reviewed
• [Journal Article] In vitro and in vivo characterization on amorphous solid dispersion of cyclosporine A for inhalation therapy (2009)
  • Author(s): Satomi Onoue, ほか
  • Journal Title: Journal off Controlled Release 138巻 Pages: 16-23
  • Peer Reviewed
• [Journal Article] Novel dry powder formulation of ovalbumin for development of COPD-like animal model : Physicochemical characterization and biomarker profiling in rats (2009)
  • Author(s): Shingen Misakae, Satomi Onoue, ほか
  • Journal Title: European Journal of Pharmaceutical Sciences 37巻 Pages: 469-476
  • Peer Reviewed
• [Journal Article] Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Attenuates Streptozotocin-Induced Apoptotic Death of RIN-m5F Cells Through Regulation of Bcl-2 Family Protein mRNA Expression (2009)
  • Author(s): Satomi, Onoue, ほか
  • Journal Title: FEBS Journal 275巻 Pages: 5542-5551
  • Peer Reviewed
• [Journal Article] Novel dry powder inhaler formulation of glucagon with addition of citric acid for enhanced pulmonary delivery. (2009)
  • Author(s): Satomi Onoue, ほか
  • Journal Title: International Journal of Pharmaceutics Volume: 382 Pages: 144-150
  • Peer Reviewed
• [Journal Article] Physicochemical and pharmacological characterization of novel vasoactive intestinal peptide derivatives with improved stability. (2009)
  • Author(s): Satomi Onoue, ほか
  • Journal Title: European Journal of Pharmaceutics and Biophar maceutics Volume: 73 Pages: 95-101
  • Peer Reviewed
• [Journal Article] In vitro and in vivo characterization on amorphous solid dispersion of cyclosporine A for inhalation therapy. (2009)
  • Author(s): Satomi Onoue, ほか
  • Journal Title: Journal off Controlled Release Volume: 138 Pages: 16-23
  • Peer Reviewed
• [Journal Article] Novel dry powder formulation of ovalbumin for development of COPD-like animal model : Physicochemical characterization and biomarker profiling in rats. (2009)
  • Author(s): Shingen Misaka, Satomi Onoue, ほか
  • Journal Title: European Journal of Pharmaceutical Sciences Volume: 37 Pages: 469-476
  • Peer Reviewed
• [Journal Article] Ncvel methodology for predicting photogenotoxic risk of pharmaceutical substances based on reactive oxvaen species (ROS) and DNA-binding assay (2009)
  • Author(s): Satomi Onoue
  • Journal Title: Journal of Pharmaceutical Sciences (In press)
  • Peer Reviewed
• [Journal Article] In vitro and in vivo characterization on amorphous solid dispersion of cyclosporine A for inhalation therapy (2009)
  • Author(s): Satomi Onoue
  • Journal Title: Journal of Controlled Release (In press)
  • Peer Reviewed
• [Journal Article] Novel Dry Powder Formulation of Ovalbumin for Development of COPD-like Animal Model : Physicochemical Characterization and Biomarker Profiling in Rats (2009)
  • Author(s): Shingen Misaka
  • Journal Title: European Journal of Pharmaceutica Sciences (In press)
  • Peer Reviewed
• [Journal Article] Physicochemical and pharmacokinetic characterization of water-soluble Coenzyme Q_<10> formulations. (2008)
  • Author(s): Junya Hatanaka, Satomi Onoue, ほか
  • Journal Title: International Journal of Pharmaceutics 363巻 Pages: 112-117
  • Peer Reviewed
• [Journal Article] Physicochemical and pharmacokinetic characterization of water-soluble Coenzyme Q_<10> formulations (2008)
  • Author(s): Junya Hatanaka
  • Journal Title: International Journal of Pharmaceutics 363 Pages: 112-117
  • Peer Reviewed
• [Journal Article] Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Attenuates Streptozotocin-Induced Apoptotic Death of RIN-m5F Cells Through Regulation of Bc1-2 Family Protein mRNA Expression (2008)
  • Author(s): Satomi Onoue
  • Journal Title: FEBS Journal 275 Pages: 5542-5551
  • Peer Reviewed
• [Presentation] Ovalbumin感作喘息モデル動物におけるCyclosporin A易溶化粉末吸入製剤の薬効および製剤学的評価 (2009)
  • Author(s): 佐藤秀行, 尾上誠良, ほか
  • Organizer: 第11回応用薬理シンポジウム
  • Place of Presentation: 静岡
  • Year and Date: 2009-09-18
• [Presentation] 持続型VIP誘導体微細化粉末吸入製剤のタバコ煙暴露モデルにおける抗炎症作用 (2009)
  • Author(s): 三坂眞元, 尾上誠良, ほか
  • Organizer: 日本薬剤学会第24年会
  • Place of Presentation: 静岡
  • Year and Date: 2009-05-21
• [Presentation] 新規VIP誘導体微細化粉末製剤の抗炎症作用 (2008)
  • Author(s): 三坂眞元, 尾上誠良, ほか
  • Organizer: 第29回日本臨床薬理学会年会
  • Place of Presentation: 東京
  • Year and Date: 2008-12-05
• [Presentation] Anti-inflammatory effects novel stabilized vasoactive intestinal peptide derivative on lung inflammation (2008)
  • Author(s): 三坂眞元, 尾上誠良, ほか
  • Organizer: The Eights China-Japan International Symposium on Health Sciences
  • Place of Presentation: Hangzhou, China
  • Year and Date: 2008-11-17
• [Presentation] Anti-inflammatory effects novel stabilized vasoactive intestinal peptide derivativeon lung inflammation (2008)
  • Author(s): Shingen Misaka
  • Organizer: The Eights China-Japan International Symposium on Health Sciences
  • Place of Presentation: Hangzhou, China
  • Year and Date: 2008-11-17
• [Presentation] Development of novel vasoactive intestinal peptide derivatives with improved stability ; physicochemical and pharmacological characterization (2008)
  • Author(s): 尾上誠良, ほか
  • Organizer: 第45回ペプチド討論会
  • Place of Presentation: 東京
  • Year and Date: 2008-10-29
• [Remarks] ホームページにおいて研究成果報告
  • URL: http://w3pharm.u-shizuoka-ken.ac.jp/~yakuzai/