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Design, synthesis, and evaluation of novel 5'-modified nucleoside analogs as anti-HCV agents

Research Project

Project/Area Number 20790106
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Drug development chemistry
Research InstitutionOtani Womens University

Principal Investigator

IKEJIRI Masahiro  Otani Womens University, 薬学部, 講師 (00412396)

Research Collaborator OHSHIMA Takayuki  徳島文理大学, 香川薬学部, 准教授
MARUYAMA Tokumi  徳島文理大学, 香川薬学部, 教授
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords医薬品化学 / ウイルス / 核酸 / 複素環 / 有機化学 / 合成化学 / 薬学
Research Abstract

Hepatitis C is an infectious disease affecting the liver, caused by the hepatitis C virus. In Japan, there are many patients suffering from the disease. Common medicines are effective to some extent, but not enough. Thus, I planned to study on the synthesis of novel compounds designed originally aiming to produce a new medicine. Unfortunately, the chemicals obtained were not so effective to the virus. However, interestingly, I found that they are likely to operate via a new type of mechanism that is different from that of the common antiviral drugs.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (6 results)

All 2009 2008 Other

All Journal Article (4 results) (of which Peer Reviewed: 2 results) Presentation (2 results)

  • [Journal Article] Synthesis and anti-HCV activity of 2',5'-deoxy-5'-phenacyladenosine analogs2009

    • Author(s)
      Ikejiri, M., Ohshima, T., Fukushima, A., Shimotohno, K., Maruyama, T.
    • Journal Title

      Nucleic Acids Symp.Ser. 53

      Pages: 103-104

    • Related Report
      2010 Final Research Report
  • [Journal Article] Synthesis and anti-HCV activity of 2',5'-deoxy-5'-phenacyladenosine analogs2009

    • Author(s)
      Masahiro Ikejiri et al.
    • Journal Title

      Nucleic Acids Symposium Series 53

      Pages: 103-104

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Synthesis and evaluation of 5'-modified 2'-deoxyadenosine analogues as anti-hepatitis C virus agents2008

    • Author(s)
      Ikejiri, M., Ohshima, T., Fukushima, A., Shimotohno, K., Maruyama, T.
    • Journal Title

      Bioorg.Med.Chem.Lett. 18

      Pages: 4638-4641

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis and evaluation of 5'-modified 2'-deoxyadenosine analogues as anti-henatitis C virus agents

    • Author(s)
      Masahiro Ikejiri, et.al.
    • Journal Title

      Bioorganic and Medicinal Chemistry Letters

      Pages: 4638-4641

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Synthesis and anti-HCV activity of 2',5'-deoxy-5'-phenacyladenosine analogs2009

    • Author(s)
      Ikejiri, M., Ohshima, T., Fukushima, A., Shimotohno, K., Maruyama, T.
    • Organizer
      The 6^<th> International Symposium onNucleic Acids Chemistry
    • Place of Presentation
      Takayama, Gifu, Japan
    • Related Report
      2010 Final Research Report
  • [Presentation] Synthesis and anti-HCV activity of 2',5'-deoxy-5'-phenacyladenosine analogs2009

    • Author(s)
      池尻昌宏
    • Organizer
      第6回国際核酸化学シンポジウム
    • Place of Presentation
      岐阜県高山市
    • Related Report
      2009 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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