Design, synthesis, and evaluation of novel 5'-modified nucleoside analogs as anti-HCV agents

• Project/Area Number: 20790106
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Drug development chemistry
• Research Institution: Otani Womens University
• Principal Investigator: IKEJIRI Masahiro Otani Womens University, 薬学部, 講師 (00412396)
• Research Collaborator: OHSHIMA Takayuki 徳島文理大学, 香川薬学部, 准教授 ; MARUYAMA Tokumi 徳島文理大学, 香川薬学部, 教授
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 医薬品化学 / ウイルス / 核酸 / 複素環 / 有機化学 / 合成化学 / 薬学

Research Abstract

Hepatitis C is an infectious disease affecting the liver, caused by the hepatitis C virus. In Japan, there are many patients suffering from the disease. Common medicines are effective to some extent, but not enough. Thus, I planned to study on the synthesis of novel compounds designed originally aiming to produce a new medicine. Unfortunately, the chemicals obtained were not so effective to the virus. However, interestingly, I found that they are likely to operate via a new type of mechanism that is different from that of the common antiviral drugs.

Research Products

• [Journal Article] Synthesis and anti-HCV activity of 2',5'-deoxy-5'-phenacyladenosine analogs (2009)
  • Author(s): Ikejiri, M., Ohshima, T., Fukushima, A., Shimotohno, K., Maruyama, T.
  • Journal Title: Nucleic Acids Symp.Ser. 53 Pages: 103-104
• [Journal Article] Synthesis and anti-HCV activity of 2',5'-deoxy-5'-phenacyladenosine analogs (2009)
  • Author(s): Masahiro Ikejiri et al.
  • Journal Title: Nucleic Acids Symposium Series 53 Pages: 103-104
• [Journal Article] Synthesis and evaluation of 5'-modified 2'-deoxyadenosine analogues as anti-hepatitis C virus agents (2008)
  • Author(s): Ikejiri, M., Ohshima, T., Fukushima, A., Shimotohno, K., Maruyama, T.
  • Journal Title: Bioorg.Med.Chem.Lett. 18 Pages: 4638-4641
  • Peer Reviewed
• [Journal Article] Synthesis and evaluation of 5'-modified 2'-deoxyadenosine analogues as anti-henatitis C virus agents
  • Author(s): Masahiro Ikejiri, et.al.
  • Journal Title: Bioorganic and Medicinal Chemistry Letters Pages: 4638-4641
  • Peer Reviewed
• [Presentation] Synthesis and anti-HCV activity of 2',5'-deoxy-5'-phenacyladenosine analogs (2009)
  • Author(s): Ikejiri, M., Ohshima, T., Fukushima, A., Shimotohno, K., Maruyama, T.
  • Organizer: The 6^<th> International Symposium onNucleic Acids Chemistry
  • Place of Presentation: Takayama, Gifu, Japan
• [Presentation] Synthesis and anti-HCV activity of 2',5'-deoxy-5'-phenacyladenosine analogs (2009)
  • Author(s): 池尻昌宏
  • Organizer: 第6回国際核酸化学シンポジウム
  • Place of Presentation: 岐阜県高山市