Analysis of environmental stress induced deafness

• Project/Area Number: 20790117
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Environmental pharmacy
• Research Institution: Chubu University
• Principal Investigator: OHGAMI Nobutaka Chubu University, 生命健康科学部, 講師 (80424919)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 環境ストレス / 騒音性難聴 / 加齢性難聴 / 内耳 / 難聴 / ラセン神経節

Research Abstract

About 30% of the 120 million people worldwide who suffer from congenital (early-onset) hearing loss are syndromic, and the remaining 70% are non-syndromic. At present, however, no effective therapies for deafness have been established except for cochlear implantation. This study demonstrated that oral administration of small molecule to C57BL/6 mice for one month significantly showed preventive effects on age-related/noise-induced deafness. This study is further trying to elucidate a mechanism for preventive effects on hearing losses.

Research Products

• [Journal Article] A redox-linked novel pathway for arsenic-mediated RET tyrosine kinase activation. (2010)
  • Author(s): Kato M, Takeda K, Hossain K, Thang ND, Yu Kaneko Y, Mayuko Kumasaka YM, Yamanoshita O, Uemura N, Takahashi M, Ohgami N, Kawamoto Y.
  • Journal Title: J Cell Biochem (in press)
  • Peer Reviewed
• [Journal Article] A redox-linked novel pathway for arsenic-mediated RET tyrosine kinase activation (2010)
  • Author(s): Kato M.
  • Journal Title: J Cell Biochem (印刷中)
  • Peer Reviewed
• [Journal Article] Ret-dependent cell rearrangements in the Wolffian duct epithelium initiate ureteric bud morphogenesis. (2009)
  • Author(s): Chi X, Michos O, Shakya R, Riccio P, Enomoto H, Licht JD, Asai N, Takahashi M, Ohgami N, Kato M, Mendelsohn C, Costantini F.
  • Journal Title: Dev Cell. 17 Pages: 199-209
  • Peer Reviewed
• [Journal Article] Zinc finger protein 28 as a novel melanoma-related molecule. (2009)
  • Author(s): Yajima I, Kumasaka M, Thang ND, Yanagishita T, Ohgami N, Kallenberg D, Naito Y, Yoshikawa T, Sakashita N, Kato M.
  • Journal Title: J Dermatol Sci. 55 Pages: 68-70
  • NAID: 10025334344
  • Peer Reviewed
• [Journal Article] Ret-dependent cell rearrangements in the Wolffian duct epithelium init fate ureteric bud morphogenesis (2009)
  • Author(s): Chi X.
  • Journal Title: Dev Cell 17 Pages: 199-209
  • Peer Reviewed
• [Journal Article] Zinc finger protein 28 as a novel melanoma-related molecule (2009)
  • Author(s): Yajima I.
  • Journal Title: J Dermatol Sci. 55 Pages: 68-70
  • Peer Reviewed
• [Journal Article] Zinc finger protein 28 as a novel melanoma-related molecule (2009)
  • Author(s): Yajima I, Kumasaka M, Thang ND, Yanagishita T, Ohgami N, Kallenberg D, Naito Y, Yoshikawa T, Sakashita N, Kato M.
  • Journal Title: J. Dermatol. Sci (印刷中)
  • NAID: 10025334344
  • Peer Reviewed
• [Presentation] 騒音性・加齢性難聴を発症したマウス内耳におけるD型アミノ酸含有タンパク質の免疫組織学的検出 (2010)
  • Author(s): 大神信孝、伊田みちる、藤井紀子、加藤昌志
  • Organizer: 第130回日本薬学会年会
  • Place of Presentation: 岡山大学津島キャンパス
  • Year and Date: 2010-03-29
• [Presentation] 騒音性・加齢性難聴を発症したマウス内耳におけるD型アミノ酸含有タンパク質の免疫組織学的検出 (2010)
  • Author(s): 大神信孝
  • Organizer: 第130回日本薬学会年会
  • Place of Presentation: 岡山大学津島キャンパス(岡山市)
  • Year and Date: 2010-03-29
• [Presentation] Biochemical analysis of the Niemann-Pick C1 protein. (2009)
  • Author(s): Nobutaka Ohgami
  • Organizer: Biomedical research seminar in Dept. of Biomedical Sciences
  • Place of Presentation: Chung Shan Medical University (Taichung, Taiwan)
  • Year and Date: 2009-12-22
• [Presentation] Biochemical analysis of the Niemann-Pick C1 protein (2009)
  • Author(s): 大神信孝
  • Organizer: Biomedical research seminar in Dept.of Biomedical Sciences
  • Place of Presentation: Taichung, Taiwan
  • Year and Date: 2009-12-22
• [Presentation] Immunological detection of D-b-aspartic acid-containing proteins in mouse inner ears with age-related hearing loss (2009)
  • Author(s): Nobutaka Ohgami, Michiru Ida, Noriko Fujii, Masashi Kato
  • Organizer: 第2回「タンパク質の異常凝集とその防御・修復機構に関する研究会」
  • Place of Presentation: 京都大学原子炉実験所(大阪府)
  • Year and Date: 2009-11-12
• [Presentation] 騒音性・加齢性難聴を発症したマウス内耳におけるD型アミノ酸含有タンパク質の検出 (2009)
  • Author(s): 大神信孝、伊田みちる、藤井紀子、土本一輝、堀創二朗、山口碧、加藤昌志
  • Organizer: 第79回日本衛生学会総会
  • Place of Presentation: 北里大学白金キャンパス(東京都)
  • Year and Date: 2009-03-31
• [Presentation] Effect of hyperpigmented skin on ultraviolet-mediated cancer (2008)
  • Author(s): Masashi Kato, Nobutaka Ohgami, Ichiro Yajima, Mayuko Kumasaka, Osamu Yamanoshita
  • Organizer: 第20回色素細胞学会国際連合学術大会・第5回メラノーマ研究医学会国際コングレス合同会議
  • Place of Presentation: ホテルロイトン札幌(北海道)
• [Remarks]
  • URL: http://web.mac.com/chubu5011/
• [Patent(Industrial Property Rights)] 難聴又は耳鳴りの予防・治療剤 (2009)
  • Inventor(s): 加藤昌志、大神信孝、伊田みちる
  • Industrial Property Rights Holder: 学校法人)中部大学
  • Industrial Property Number: 2009-185334
  • Filing Date: 2009-08-08
• [Patent(Industrial Property Rights)] 難聴モデル動物及びその用途 (2009)
  • Inventor(s): 大神信孝、加藤昌志、高橋雅英、浅井直也、時々輪真由美
  • Industrial Property Rights Holder: 学校法人中部大学、国立大学法人名古屋大学
  • Industrial Property Number: 2009-053481
  • Filing Date: 2009-03-06