Establishment of optimal conversion ratios of opioid analgesics based on genetic polymorphisms in individual palliative care
| Project/Area Number |
20790132
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Medical pharmacy
|
|---|
| Research Institution | Hamamatsu University School of Medicine |
|---|
Principal Investigator |
NAITO Takafumi Hamamatsu University School of Medicine, 医学部附属病院, 副薬剤部長 (80422749)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | オピオイド / がん性疼痛 / オーダーメード医療 / 遺伝子多型 / オピオイドローテーション / 緩和医療 / フェンタニル / テーラーメイド医療 / オキシコドン |
|---|
| Research Abstract |
Opioid switching is useful for the improvement of pain control, the avoidance of opioid-induced adverse reaction and tolerance formation, and the change of administration route in patients with cancer pain. This study developed the conversion ratios of oral oxycodone to transdermal fentanyl based on genetic polymorphisms of the drug-metabolizing enzymes, drug transporter, and opioid receptor in cancer patients.
|
Report
(4 results)
Research Products
(12 results)
