Investigation of OFA-iLRP targeted cancer immunother apy against lung cancer

Research Project

Project/Area Number	20790136
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Medical pharmacy
Research Institution	The University of Tokushima
Principal Investigator	ABE Shinji The University of Tokushima, 医学部・歯学部附属病院, 助教 (00403717)
Project Period (FY)	2008 – 2009
Project Status	Completed (Fiscal Year 2009)
Budget Amount *help	¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000) Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000) Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords	トランスレーショナルリサーチ / 癌 / 免疫療法 / 癌抗原
Research Abstract	In this study, I have investigated whether OFA-iLRP is expressed on human lung cancer tissues and whether OFA-iLRP peptides treated dendritic cells induce OFA-iLRP specific CTLs. Our results show that most human lung cancer tissues express OFA-iLRP and dendritic cells treated by OFA-iLRP peptides induce CTLs. Considering these results, OFA-iLRP may represent a suitable target against advanced lung cancer.

Report

(3 results)