| Project/Area Number |
20790151
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Medical pharmacy
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| Research Institution | Kyoto Pharmaceutical University |
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Principal Investigator |
TSUJIMOTO Masayuki Kyoto Pharmaceutical University, 薬学部, 助教 (90372739)
|
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| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 薬物動態・代謝学 / 腎不全 / 腎不全患者(透析患者) / 腎外クリアランス / 尿毒症物質 / 薬物代謝酵素 / トランスポーター / 透析患者 / プラバスタチン / ロサルタン |
|---|
| Research Abstract |
In the patients with renal failure, it is known that the patients are decreasing not only renal clearance but also non-renal clearance. This study suggested that the decrease in non-renal clearance of antihypertensive drug losartan was induced by the inhibition of hepatic metabolism by uremic toxins, indoxyl sulfate and p-cresol. In addition, this study suggested that the decreased in non-renal clearance of lipid-lowering drug pravastatin was induced by the suppression of intestinal efflux transporter.
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