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Mechanisms of KCNQ1 channel modulation by KCNE proteins revealed by ascidian KCNQ1 homologue

Research Project

Project/Area Number 20790184
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field General physiology
Research InstitutionNational Institute for Physiological Sciences

Principal Investigator

NAKAJO Koichi  National Institute for Physiological Sciences, 分子生理研究系, 助教 (80390699)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywordsイオンチャネル / カリウムチャネル / 生物物理学 / 生理学 / 電位センサー / 電気生理学 / 分子生物学 / ホヤ / 不整脈 / 心筋
Research Abstract

KCNQ1, a voltage-gated potassium channel main subunit, is expressed in various tissues like heart, inner ear and intestine, and also known as a causative gene for cardiac arrhythmia and deafness. The property of this ion channel is largely dependent on its auxiliary subunit, KCNE proteins. In this study, we identified some important amino acid residues for KCNQ1 channel modulation by KCNE proteins by comparing human KCNQ1 gene to KCNQ1 homologue from ascidian Ciona intestinalis

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (19 results)

All 2010 2009 2008 Other

All Journal Article (9 results) (of which Peer Reviewed: 9 results) Presentation (8 results) Remarks (2 results)

  • [Journal Article] Identification and characterization of Cs+-permeable K+ channel current in mouse cerebellar Purkinje cells in lobules 9 and 10 evoked by molecular layer stimulation2010

    • Author(s)
      Ishii H, Nakajo K, Yanagawa Y, Kubo Y.
    • Journal Title

      Eur J Neurosci (in press)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Voltage- and [ATP]-dependent gating of the P2X2ATP receptor channel2009

    • Author(s)
      Fujiwara Y, Keceli B, Nakajo K, Kubo Y.
    • Journal Title

      J Gen Physiol 133(1)

      Pages: 93-109

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dynamic aspects of functional regulation of the ATP receptor channel P2X22009

    • Author(s)
      Kubo Y, Fujiwara Y, Keceli B, Nakajo K.
    • Journal Title

      J Physiol. 587(Pt22)

      Pages: 5317-24

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dynamic aspects of functional regulation of the ATP receptor channel P2X_22009

    • Author(s)
      Kubo Y, Fujiwara Y, Keceli B, Nakajo K
    • Journal Title

      Journal of Physiology 587

      Pages: 5317-5324

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Voltage-and [ATP]-dependent gating of the P2X (2) ATP receptor channel2009

    • Author(s)
      Fujiwara Y, Keceli, B, Nakajo K & Kubo Y
    • Journal Title

      Journal of General Physiology 133

      Pages: 93-109

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cooper EC Ion channel clustering at the axon initial segment and node of Ranvier evolved sequentially in early chordates2008

    • Author(s)
      Hill AS, Nishino A, Nakajo K, Zhang G, Fineman JR, Selzer ME, Okamura Y
    • Journal Title

      PLoS Genet. 4(12)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Second coiled-coil domain of KCNQ channel controls current expression and subfamily specific heteromultimerization by salt bridge networks2008

    • Author(s)
      Nakajo K, Kubo Y
    • Journal Title

      J Physiol. 586

      Pages: 2827-40

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Second coiled-coil domain of KCNQ channel controls current expression and subfamily specific heteromultimerization by salt bridge networks2008

    • Author(s)
      Koichi Nakajo & Yoshihiro Kubo
    • Journal Title

      Journal of Physiology 586

      Pages: 2827-2840

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ion channel clustering at the axon initial segment and node of ranvier evolved sequentially in early chordates2008

    • Author(s)
      Hill AS, Nishino A, Nakajo K, Zhang G, Fineman JR, et.al.
    • Journal Title

      PLoS Genetics 4

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Stoichiometry of KCNQ1-KCNE1 ion channel complex is flexible and density dependent2010

    • Author(s)
      Koichi Nakajo, Maximilian Ulbrich, Yoshihiro Kubo, Ehud Isacoff
    • Organizer
      Biophysical Society 54th Annual Meeting
    • Place of Presentation
      モスコーンセンター(サンフランシスコ、米国)
    • Year and Date
      2010-02-21
    • Related Report
      2009 Final Research Report
  • [Presentation] Stoichiometry of KCNQ1-KCNE1 ion channel complex is flexible and density-dependent2010

    • Author(s)
      Nakajo K, Ulbrich MH, Kubo Y, Isacoff EY
    • Organizer
      Biophysical Society 54th Annual Meeting
    • Place of Presentation
      モスコーンセンター(サンフランシスコ(米国))
    • Year and Date
      2010-02-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] KCNQ1チャネル複合体ストイキオメトリーの発現依存的変化2009

    • Author(s)
      Koichi Nakajo, Maximilian Ulbrich, Yoshihiro Kubo, Ehud Isacoff
    • Organizer
      日本生物物理学会第47回年会
    • Place of Presentation
      アスティ徳島(徳島)
    • Year and Date
      2009-10-31
    • Related Report
      2009 Final Research Report
  • [Presentation] KCNQ1チャネル複合体ストイキオメトリーの密度依存的変化2009

    • Author(s)
      Nakajo K, Ulbrich MH, Kubo Y, Isacoff EY
    • Organizer
      第47回生物物理学会年会
    • Place of Presentation
      アスティとくしま(徳島)
    • Year and Date
      2009-10-31
    • Related Report
      2009 Annual Research Report
  • [Presentation] KCNE1 modulates KCNQ1 through specific amino acid residues in the pore region2009

    • Author(s)
      Koichi Nakajo, Atsuo Nishino, Yasushi Okamura, Yoshihiro Kubo
    • Organizer
      国際生理学会IUPS2009
    • Place of Presentation
      京都国際会議場(京都)
    • Year and Date
      2009-07-29
    • Related Report
      2009 Final Research Report
  • [Presentation] KCNE1 modulates KCNQ1 through specific amino acid residues in the pore region2009

    • Author(s)
      Nakajo K, Nishino A, Okamura Y, Kubo Y
    • Organizer
      The 36^<th> congress of the international union of physiological sciences
    • Place of Presentation
      京都国際会館(京都)
    • Year and Date
      2009-07-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] KCNQカリウムチャネル電位センサードメインのダイナミクスとその制御機構2008

    • Author(s)
      中條浩一、久保義弘
    • Organizer
      日本生物物理学会第46回年会
    • Place of Presentation
      福岡国際会議場(福岡)
    • Year and Date
      2008-12-03
    • Related Report
      2009 Final Research Report
  • [Presentation] KCNQカリウムチャネル電位センサードメインのダイナミクスとその制御機構2008

    • Author(s)
      中條浩一
    • Organizer
      日本生物物理学会第46回年会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2008-12-03
    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://www.nips.ac.jp/contents/release/entry/2008/07/kcnq.html

    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://www.nips.ac.jp/news/2008/20080703/

    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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