2009 Fiscal Year Final Research Report
Mechanisms of KCNQ1 channel modulation by KCNE proteins revealed by ascidian KCNQ1 homologue
| Project/Area Number |
20790184
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General physiology
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| Research Institution | National Institute for Physiological Sciences |
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Principal Investigator |
NAKAJO Koichi National Institute for Physiological Sciences -> 生理学研究所, 分子生理研究系, 助教 (80390699)
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| Project Period (FY) |
2008 – 2009
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| Keywords | イオンチャネル / カリウムチャネル / 生物物理学 / 生理学 / 電位センサー |
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| Research Abstract |
KCNQ1, a voltage-gated potassium channel main subunit, is expressed in various tissues like heart, inner ear and intestine, and also known as a causative gene for cardiac arrhythmia and deafness. The property of this ion channel is largely dependent on its auxiliary subunit, KCNE proteins. In this study, we identified some important amino acid residues for KCNQ1 channel modulation by KCNE proteins by comparing human KCNQ1 gene to KCNQ1 homologue from ascidian Ciona intestinalis
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Research Products
(10 results)
