• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2009 Fiscal Year Final Research Report

Mechanisms of KCNQ1 channel modulation by KCNE proteins revealed by ascidian KCNQ1 homologue

Research Project

  • PDF
Project/Area Number 20790184
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field General physiology
Research InstitutionNational Institute for Physiological Sciences

Principal Investigator

NAKAJO Koichi  National Institute for Physiological Sciences, 分子生理研究系, 助教 (80390699)

Project Period (FY) 2008 – 2009
Keywordsイオンチャネル / カリウムチャネル / 生物物理学 / 生理学 / 電位センサー
Research Abstract

KCNQ1, a voltage-gated potassium channel main subunit, is expressed in various tissues like heart, inner ear and intestine, and also known as a causative gene for cardiac arrhythmia and deafness. The property of this ion channel is largely dependent on its auxiliary subunit, KCNE proteins. In this study, we identified some important amino acid residues for KCNQ1 channel modulation by KCNE proteins by comparing human KCNQ1 gene to KCNQ1 homologue from ascidian Ciona intestinalis

  • Research Products

    (10 results)

All 2010 2009 2008 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (4 results) Remarks (1 results)

  • [Journal Article] Identification and characterization of Cs+-permeable K+ channel current in mouse cerebellar Purkinje cells in lobules 9 and 10 evoked by molecular layer stimulation2010

    • Author(s)
      Ishii H, Nakajo K, Yanagawa Y, Kubo Y.
    • Journal Title

      Eur J Neurosci (in press)

    • Peer Reviewed
  • [Journal Article] Voltage- and [ATP]-dependent gating of the P2X2ATP receptor channel2009

    • Author(s)
      Fujiwara Y, Keceli B, Nakajo K, Kubo Y.
    • Journal Title

      J Gen Physiol 133(1)

      Pages: 93-109

    • Peer Reviewed
  • [Journal Article] Dynamic aspects of functional regulation of the ATP receptor channel P2X22009

    • Author(s)
      Kubo Y, Fujiwara Y, Keceli B, Nakajo K.
    • Journal Title

      J Physiol. 587(Pt22)

      Pages: 5317-24

    • Peer Reviewed
  • [Journal Article] Cooper EC Ion channel clustering at the axon initial segment and node of Ranvier evolved sequentially in early chordates2008

    • Author(s)
      Hill AS, Nishino A, Nakajo K, Zhang G, Fineman JR, Selzer ME, Okamura Y
    • Journal Title

      PLoS Genet. 4(12)

      Pages: e1000317

    • Peer Reviewed
  • [Journal Article] Second coiled-coil domain of KCNQ channel controls current expression and subfamily specific heteromultimerization by salt bridge networks2008

    • Author(s)
      Nakajo K, Kubo Y
    • Journal Title

      J Physiol. 586

      Pages: 2827-40

    • Peer Reviewed
  • [Presentation] Stoichiometry of KCNQ1-KCNE1 ion channel complex is flexible and density dependent2010

    • Author(s)
      Koichi Nakajo, Maximilian Ulbrich, Yoshihiro Kubo, Ehud Isacoff
    • Organizer
      Biophysical Society 54th Annual Meeting
    • Place of Presentation
      モスコーンセンター(サンフランシスコ、米国)
    • Year and Date
      2010-02-21
  • [Presentation] KCNQ1チャネル複合体ストイキオメトリーの発現依存的変化2009

    • Author(s)
      Koichi Nakajo, Maximilian Ulbrich, Yoshihiro Kubo, Ehud Isacoff
    • Organizer
      日本生物物理学会第47回年会
    • Place of Presentation
      アスティ徳島(徳島)
    • Year and Date
      2009-10-31
  • [Presentation] KCNE1 modulates KCNQ1 through specific amino acid residues in the pore region2009

    • Author(s)
      Koichi Nakajo, Atsuo Nishino, Yasushi Okamura, Yoshihiro Kubo
    • Organizer
      国際生理学会IUPS2009
    • Place of Presentation
      京都国際会議場(京都)
    • Year and Date
      2009-07-29
  • [Presentation] KCNQカリウムチャネル電位センサードメインのダイナミクスとその制御機構2008

    • Author(s)
      中條浩一、久保義弘
    • Organizer
      日本生物物理学会第46回年会
    • Place of Presentation
      福岡国際会議場(福岡)
    • Year and Date
      2008-12-03
  • [Remarks]

    • URL

      http://www.nips.ac.jp/contents/release/entry/2008/07/kcnq.html

URL: 

Published: 2011-06-18   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi