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The effects of sex-specific, developmental stage-dependent environments on the declines of cognitive functions followed by aging

Research Project

Project/Area Number 20790193
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Environmental physiology (including Physical medicine and Nutritional physiology)
Research InstitutionHimeji Dokkyo University

Principal Investigator

TAKASE Kenkichi  Himeji Dokkyo University, 薬学部, 講師 (80381474)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords老化 / 環境 / 性差 / 認知 / 認知機能 / 生活環境 / 発達 / 社会性 / 養育環境 / 栄養状態 / アセチルコリン / 海馬 / 前頭前野
Research Abstract

The purpose of this study is to identify the sex-specific dietary intake and momentum which prevent the decline of the activity in the cholinergic neurons from aging. In this research, we accidentally found that the male rats experiencing the undernutrition on postnatal day 9 and 11 showed social deficits without abnormalities in perception, motor functions, and cognitive functions. These abnormalities were not observed in females. These results suggest that the appropriate environments to develop brain functions are sex dependent, and that male rats are vulnerable to the undernutrition during infancy affecting the emotionality and sociality in adult life.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (31 results)

All 2010 2009 2008 Other

All Journal Article (10 results) (of which Peer Reviewed: 5 results) Presentation (14 results) Book (5 results) Remarks (2 results)

  • [Journal Article] Fibroblast growth factor 2 induces apoptosis in the early primary culture of rat cortical neurons.2010

    • Author(s)
      Yagami T, Takase K, Yamamoto Y, Keiichi U, Takasu N, Okamura N, Sakaeda T, Fujimoto M.
    • Journal Title

      Exp Cell Res. (in press)

    • Related Report
      2009 Final Research Report
  • [Journal Article] Fibroblast growth factor 2 induces apoptosis in the early primary culture of rat cortical neurons2010

    • Author(s)
      Yagami T, Takase K, Yamamoto Y, Ueda K, Takasu N, Okamura N, Sakaeda Y, Fujimoto M.
    • Journal Title

      Experimental Cell Research (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gonadal steroids maintain 24-h acetylcholine release in the hippocampus: organizational and activational effects in behaving rats.2009

    • Author(s)
      Mitsushima D, Takase K, Funabashi T, Kimura F.
    • Journal Title

      J Neurosci. 29(12)

      Pages: 3808-3815

    • Related Report
      2009 Final Research Report
  • [Journal Article] Sex-specific 24-h acetylcholine release profile in the medial prefrontal cortex: Simultaneous measurement of spontaneous locomotor activity in behaving rats.2009

    • Author(s)
      Takase K, Mitsushima D, Yagami T, Kimura F.
    • Journal Title

      Neuroscience 159(1)

      Pages: 7-15

    • Related Report
      2009 Final Research Report
  • [Journal Article] Activational and organizational effects of gonadal steroids on sex-specific acetylcholine release in the dorsal hippocampus.2009

    • Author(s)
      Mitsushima D, Takase K, Takahashi T, Kimura F.
    • Journal Title

      J Neuroendocrinol 21(4)

      Pages: 400-405

    • Related Report
      2009 Final Research Report
  • [Journal Article] 空間認知能力の性差は氏か育ちか?-性差形成要因をめぐるヒトとラットにおける研究の動向-2009

    • Author(s)
      高瀬堅吉
    • Journal Title

      行動科学(総説) 48

      Pages: 69-82

    • Related Report
      2009 Final Research Report
  • [Journal Article] 空間認知能力の性差は氏か育ちか? -性差形成要因をめぐるヒトとラットにおける研究の動向-2009

    • Author(s)
      高瀬堅吉
    • Journal Title

      行動科学 48

      Pages: 87-100

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sex-specific 24-h acetylcholine release profile in the medial prefrontal cortex : Simultaneous measurement of spontaneous locomotor activity in behaving rats2009

    • Author(s)
      Takase K, Mitsushima D, Yagami T, Kimura F
    • Journal Title

      Neuroscience 159

      Pages: 7-15

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gonadal steroids maintain 24-h acetylcholine release in the hippocampus : organizational and activational effects in behaving rats2009

    • Author(s)
      Mitsushima D, Takase K, Funabashi T, Kimura F
    • Journal Title

      Journal of Neuroscience 29

      Pages: 3808-3815

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activational and organizational effects of gonadal steroids on sex-specific acetylcholine release in the dorsal hippocampus2009

    • Author(s)
      Mitsushima D, Takase K, Funabashi T, Takahashi T, Kimura F
    • Journal Title

      Journal of Neuroendocrinology 21

      Pages: 400-405

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 腎臓がん細胞におけるトログリタゾンの抗腫瘍活性の検討2010

    • Author(s)
      藤田恵、田路千明、澤田京子、山本泰弘、高瀬堅吉、矢上達郎、岡村昇
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Related Report
      2009 Final Research Report
  • [Presentation] 腎臓癌細胞における低酸素誘導VEGF発現増強はVHL非依存的経路を介する2010

    • Author(s)
      Yamamoto Y, Takase K, Matsumoto J, Yoshida T, Nakamura T, Okamura N, Sakaeda T, Okumura K, Yagami T., 山本泰弘、高瀬堅吉、松本準、吉田泰三、中村任、岡村昇、栄田敏之、奥村勝彦、矢上達郎
    • Organizer
      第83回日本薬理学会年会
    • Place of Presentation
      大阪
    • Related Report
      2009 Final Research Report
  • [Presentation] Early maternal deprivation enhances anxiety and stereotypy, but reduces sociality in adult male rats2009

    • Author(s)
      Takase K, Yamamoto Y, Yagami T.
    • Organizer
      日本神経科学学会
    • Place of Presentation
      名古屋国際会議場(愛知)
    • Year and Date
      2009-09-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] Identification of novel protein targets for modification by 15-deoxy-^Δ12,14-prostaglandin J2 in neuronal plasma membranes2009

    • Author(s)
      Yagami T, Takase K, Yamamoto Y.
    • Organizer
      日本神経科学学会
    • Place of Presentation
      名古屋国際会議場(愛知)
    • Year and Date
      2009-09-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] Identification of novel protein targets for modification by 15-deoxy-△12, 14-prostaglandin J2 in neuronal plasma membranes.2009

    • Author(s)
      Yagami T, Takase K, Yamamoto Y.
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋
    • Related Report
      2009 Final Research Report
  • [Presentation] 早期母子分離は成熟雄性ラットにおける不安・常同性を高め、社会性を低下させる2009

    • Author(s)
      Takase K, Yamamoto Y, Yagami T.
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋
    • Related Report
      2009 Final Research Report
  • [Presentation] 社会的隔離によるグルココルチコイドを介した皮質形成異常2009

    • Author(s)
      宮崎智之、高瀬堅吉、多田孔典、美津島大、高橋琢哉
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋
    • Related Report
      2009 Final Research Report
  • [Presentation] 記憶の性差の生物学的基盤2009

    • Author(s)
      高瀬堅吉
    • Organizer
      日本心理学会第73回大会
    • Place of Presentation
      京都
    • Related Report
      2009 Final Research Report
  • [Presentation] Serotonin facilitates AMPA receptor trafficking in the developing barrel cortex of rats with visual deprivation.2008

    • Author(s)
      Jitsuki S, Takase K, Takahashi T.
    • Organizer
      第31回日本神経科学大会
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Presentation] Social isolation disrupts experience-driven synaptic delivery of AMPA receptors in developing rat barrel cortex via glucocorticoid.2008

    • Author(s)
      Miyazaki T, Takase K, Mitsushima D, Takahashi T.
    • Organizer
      第31回日本神経科学大会
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Presentation] アミロイドーシスにおける15-deoxy-Δ12, 14-prostaglandin J2関与の可能性2008

    • Author(s)
      矢上達郎, 高瀬堅吉
    • Organizer
      第31回日本神経科学大会
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Presentation] Serotonin facilitates AMPA receptor trafficking in the developing barrel cortex of rats with visual deprivation2008

    • Author(s)
      Jitsuki S, Takase K, Takahachi T
    • Organizer
      日本神経科学学会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] Social isolation disrupts experience-driven synaptic delivery of AMPA receptors in developing rat barrel cortex via glucocorticoid2008

    • Author(s)
      Miyazaki T, Takase K, Mitsushima D, Takahashi T
    • Organizer
      日本神経科学学会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] Apossible involvement of 15-deoxy-△12,14-prostaglandin J2 in amyloidosis2008

    • Author(s)
      Yagami T, Takase K.
    • Organizer
      日本神経科学学会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Book] Horizons in Neuroscience Research, Volume 22010

    • Author(s)
      Takase K, Mitsushima D.
    • Total Pages
      24
    • Publisher
      Nova Science Publishers
    • Related Report
      2009 Annual Research Report
  • [Book] 心理学検定重要キーワード集2009

    • Author(s)
      近藤保彦, 高瀬堅吉
    • Related Report
      2009 Final Research Report
  • [Book] 心理学検定模 擬問題集2009

    • Author(s)
      近藤保彦, 高瀬堅吉
    • Related Report
      2009 Final Research Report
  • [Book] 心理学検定公式問題集神経・生理領域2009

    • Author(s)
      近藤保彦, 高瀬堅吉
    • Total Pages
      371
    • Publisher
      実務教育出版
    • Related Report
      2008 Annual Research Report
  • [Book] Sex difference in learning and memory: effects of sex differentiation, development, and environments on the forebrain cholinergic system.

    • Author(s)
      Takase K, Mitsushima D.
    • Publisher
      Nova Science Publishers
    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://www.himeji-du.ac.jp/faculty/professor/dp_pharm/takase.html

    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://www.himeji-du.ac.jp/faculty/professor/dp_pharm/takase.html

    • Related Report
      2009 Annual Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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