| Project/Area Number |
20790193
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | Himeji Dokkyo University |
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Principal Investigator |
TAKASE Kenkichi Himeji Dokkyo University, 薬学部, 講師 (80381474)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 老化 / 環境 / 性差 / 認知 / 認知機能 / 生活環境 / 発達 / 社会性 / 養育環境 / 栄養状態 / アセチルコリン / 海馬 / 前頭前野 |
|---|
| Research Abstract |
The purpose of this study is to identify the sex-specific dietary intake and momentum which prevent the decline of the activity in the cholinergic neurons from aging. In this research, we accidentally found that the male rats experiencing the undernutrition on postnatal day 9 and 11 showed social deficits without abnormalities in perception, motor functions, and cognitive functions. These abnormalities were not observed in females. These results suggest that the appropriate environments to develop brain functions are sex dependent, and that male rats are vulnerable to the undernutrition during infancy affecting the emotionality and sociality in adult life.
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