The effect of stress-induced sympathetic activation on ovarian hormonal function.

• Project/Area Number: 20790197
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Environmental physiology (including Physical medicine and Nutritional physiology)
• Research Institution: Tokyo Metropolitan Institute of Gerontology
• Principal Investigator: UCHIDA Sae Tokyo Metropolitan Institute of Gerontology, 東京都健康長寿医療センター研究所, 研究員 (90270660)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: ストレス / 卵巣ホルモン / 自律神経 / 皮膚刺激 / ラット

Research Abstract

ストレス時に亢進する交感神経が卵巣内分泌機能に与える影響とその機序を麻酔ラットで検討した.卵巣支配の2種の交感神経のうち上卵巣神経のC線維の亢進で卵巣からのエストラジオール分泌低下が起こること,この反応にはα_2アドレナリン受容体が関与することを明らかにした.更に,卵巣交感神経活動を亢進させるストレス刺激である皮膚侵害性刺激が,卵巣エストラジオール分泌を低下することを見いだした.

Research Products

• [Journal Article] Neural mechanisms of reflex inhibition of heart rate elicited by acupuncture-like stimulation in anesthetized rats. (2010)
  • Author(s): Uchida, S., Kagitani, F., Hotta, H.
  • Journal Title: Autonomic Neuroscience: Basic & Clinical (in press)
  • Peer Reviewed
• [Journal Article] Sympatho-inhibitory response of the heart as a result of short-term acupuncture-like stimulation of the rat hindlimb is not augmented when sympathetic tone is high due to hypercapnia. (2010)
  • Author(s): Uchida, S., Kagitani, F., Watanabe, F., Hotta, H.
  • Journal Title: Journal of Physiological Sciences 60巻 Pages: 221-225
  • Peer Reviewed
• [Journal Article] Sympatho-inhibitory response of the heart as a result of short-term acupuncture-like stimulation of the rat hindlimb is not augmented when sympathetic tone is high as a result of hypercapnia. (2010)
  • Author(s): Uchida S., Kagitani F., Watanabe N., Hotta H.
  • Journal Title: Journal of Physiological Sciences 60 Pages: 221-225
  • NAID: 10027711902
  • Peer Reviewed
• [Journal Article] Sympathetic neural regulation of olfactorY bulb blood flow in adult and agedrats. (2009)
  • Author(s): Shima K, Machida T., Uchida S., Hotta H.
  • Journal Title: Autonomic Neuroscience : Basic and Clinical 147 Pages: 75-79
  • Peer Reviewed
• [Journal Article] Effects of electrical stimulation of the superior ovarian nerve and the ovarian plexus nerve on the ovarian estradiol secretion rate in rats. (2008)
  • Author(s): Kagitani, F., Uchida, S., Hotta, H.
  • Journal Title: Journal of Physiological Sciences 58巻 Pages: 133-138
  • NAID: 10022597975
  • Peer Reviewed
• [Journal Article] Mechanism of the reflex inhibition of heart rate elicited by acupuncture-like stimulation in anesthetized rats. (2008)
  • Author(s): Uchida, S., Kagitani, F., Hotta, H.
  • Journal Title: Autonomic Neuroscience: Basic & Clinical 143巻 Pages: 12-19
  • Peer Reviewed
• [Journal Article] Acupuncture affects regional blood flow in various organs. (2008)
  • Author(s): Uchida, S., Hotta, H.
  • Journal Title: Evidence-based Complementary and Alternative Medicine 5巻 Pages: 145-151
  • Peer Reviewed
• [Journal Article] Somatosensory modulation of ovarian blood flow in rats. (2008)
  • Author(s): Uchida, S
  • Journal Title: The Autonomic Nervous System 45巻 Pages: 43-49
  • NAID: 10024485822
• [Journal Article] Effect of electrical stimulation of the superior ovarian nerve and the ovarian plexus nerve on the ovarian estradiol secretion rate in rats. (2008)
  • Author(s): Kagintani F., Uchida S., Hotta H.
  • Journal Title: Journal of Physiological Sciences 58 Pages: 133-138
  • NAID: 10022597975
  • Peer Reviewed
• [Presentation] 卵巣自律神経の形態及び機能の加齢変化 (2009)
  • Author(s): 内田さえ, 鍵谷方子, 堀田晴美
  • Organizer: 第37回自律神経生理研究会
  • Place of Presentation: 東京
  • Year and Date: 2009-12-05
• [Presentation] 卵巣自律神経の加齢変化 (2009)
  • Author(s): 内田さえ, 鍵谷方子, 花田智子, 堀田晴美
  • Organizer: 第62回日本自律神経学会総会
  • Place of Presentation: 和歌山
• [Presentation] Neural mechanism of reflex inhibition of heart rate elicited by acupuncture-like stimulation in anesthetized rats. (2009)
  • Author(s): Uchida, S., Kagitani, F., Hotta, H.
  • Organizer: 6th Congress of The International Society for Autonomic Neuroscience
  • Place of Presentation: Sydney
• [Presentation] The ovarian estradiol secretion rate is regulated by superior ovarian nerve in rats. (2009)
  • Author(s): Kagitani, F., Uchida, S., Hotta, H.
  • Organizer: 36th International Congress of Physiological Sciences
  • Place of Presentation: Kyoto
• [Presentation] Neural mechanism of acupuncture effects on cardiac function. (2009)
  • Author(s): Uchida, S.
  • Organizer: 36th International Congress of Physiological Sciences
  • Place of Presentation: Kyoto
• [Presentation] Regulation of the ovarian estradiol secretion rate by superior ovarian nerve in rats. (2009)
  • Author(s): Kagitani, F., Uchida, S., Hotta, H.
  • Organizer: 24th Meeting of British Society for Neuroendocrinology
  • Place of Presentation: Edinburgh
• [Presentation] The ovarian estradiol secretion rate is regulated by superior ovarian nerve in rats. (2009)
  • Author(s): Kagitani F., Uchida S.. Hotta H.
  • Organizer: 36^<th> International Congress of Physiological Sciences
  • Place of Presentation: 京都(国立京都国際会館)
• [Presentation] Regulation of the ovarian estradiol secretion rate by superior ovarian nerve in rats. (2009)
  • Author(s): Kagitani F., Uchida, S., Hotta, H
  • Organizer: British Society for Neurcendocrinology
  • Place of Presentation: Edinburgh
• [Presentation] 卵巣自律神経の電気刺激が卵巣エストラジオール分泌速度に及ぼす影響 (2008)
  • Author(s): 内田さえ, 鍵谷方子, 堀田晴美
  • Organizer: 第36回自律神経生理研究会
  • Place of Presentation: 東京
  • Year and Date: 2008-12-06
• [Presentation] Autonomic nervous regulation of ovarian estradiol secretion rate in rats. (2008)
  • Author(s): Uchida S., Kagitani, F., Hotta H.
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
• [Presentation] 卵巣自律神経の形態および機能の加齢変化 (2008)
  • Author(s): 内田さえ, 金井千恵子, 花田智子, 堀田晴美
  • Organizer: 日本基礎老化学会第31回大会
• [Presentation] ラット卵巣のエストラジオール分泌の自律神経性調整 (2008)
  • Author(s): 内田さえ, 鍵谷方子, 堀田晴美
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
• [Presentation] ラットにおいて上卵巣神経と卵巣動脈神経叢の電気刺激が卵巣エストラジオール分泌速度に及ぼす影響 (2008)
  • Author(s): 鍵谷方子, 内田さえ, 堀田晴美
  • Organizer: 第61回日本自律神経学会総会
  • Place of Presentation: 横浜
• [Book] 3. 神経系3. 1反射b)成人～老年, からだの年齢事典, 鈴木隆雄, 衞藤隆(編) (2008)
  • Author(s): 内田さえ
  • Publisher: 朝倉書店
• [Book] 6章生殖・成長と老化, コメディカルのための専門基礎分野テキスト生理学2版(黒澤美枝子, 長谷川薫編) (2008)
  • Author(s): 内田さえ, 花田智子
  • Publisher: 中外医学社