| Project/Area Number |
20790221
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General medical chemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KIMURA Sayaka The University of Tokyo, 大学院・医学系研究科, 助教 (70372365)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 樹状突起 / CaMK / 脂質修飾 / プレニル化 / パルミトイル化 |
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| Research Abstract |
We previously identified and cloned CLICK-III/CaMKIγ, a novel lipid-anchored neuronal CaM kinase, which we further showed played a critical role in dendritogenesis in cultured cortical neurons. Here, we attempted to investigate the physiological functions of this kinase in mouse tissues in vivo. In order to obtain clues about the neuronal functions associated with CLICK-III/CaMKIγ, we generated a knockout mouse with a view to carrying out histological and behavioral analyses. Furthermore, we established in vivo gene transfer methods to study the impact of CLICK-III and related CaMKI isoforms in regulating fine neuronal morphologies during brain development.
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