Regulation of neuronal functions by a lipid-anchored CaM kinase
Project/Area Number |
20790221
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
General medical chemistry
|
Research Institution | The University of Tokyo |
Principal Investigator |
KIMURA Sayaka The University of Tokyo, 大学院・医学系研究科, 助教 (70372365)
|
Project Period (FY) |
2008 – 2009
|
Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 樹状突起 / CaMK / 脂質修飾 / プレニル化 / パルミトイル化 |
Research Abstract |
We previously identified and cloned CLICK-III/CaMKIγ, a novel lipid-anchored neuronal CaM kinase, which we further showed played a critical role in dendritogenesis in cultured cortical neurons. Here, we attempted to investigate the physiological functions of this kinase in mouse tissues in vivo. In order to obtain clues about the neuronal functions associated with CLICK-III/CaMKIγ, we generated a knockout mouse with a view to carrying out histological and behavioral analyses. Furthermore, we established in vivo gene transfer methods to study the impact of CLICK-III and related CaMKI isoforms in regulating fine neuronal morphologies during brain development.
|
Report
(3 results)
Research Products
(19 results)
-
[Journal Article] Control of cortical axon elongation by a GABA-driven Ca2+/calmodulin-dependent protein kinase cascade.2009
Author(s)
Ageta-Ishihara N, Takemoto-Kimura S, Nonaka M, Adachi-Morishima A, Suzuki K, Kamijo S, Fujii H, Mano T, Blaeser F, Chatila TA, Mizuno H, Hirano T, Tagawa Y, Okuno H, Bito H
-
Journal Title
The Journal of neuroscience 29
Pages: 13720-9
Related Report
Peer Reviewed
-
-
-
-
[Journal Article] Control of cortical axon elongation by a GABA-driven Ca2+/calmodulin-dependent protein kinase cascade2009
Author(s)
Ageta-Ishihara N, Takemoto-Kimura S, Nonaka M, Adachi-Morishima A, Suzuki K, Kamijo S, Fujii H, Mano T, Blaeser F, Chatila TA, Mizuno H, Hirano T, Tagawa Y, Okuno H, Bito H
-
Journal Title
The Journal of neuroscience 29
Pages: 13720-13729
Related Report
Peer Reviewed
-
-
-
-
-
[Presentation] 大脳皮質2/3層錐体細胞の放射状移動を制御する新たなカルシウムエフェクターCaMKIalphaの機能解明2009
Author(s)
安達-森島亜希, 竹本-木村さやか, 鈴木敢三, 上田(石原)奈津美, 野中美応, 岡村理子, 西村嘉晃, 川内健史, 仲嶋一範, 奥野浩行, 尾藤晴彦
Organizer
第82回日本生化学大会
Place of Presentation
神戸市・神戸国際会議場
Year and Date
2009-10-24
Related Report
-
[Presentation] A pivotal role of a CaMKK-Ca2+/calmodulin-dependent protein kinase I cascade in the radial migration of layer 2/3 cortical pyramidal neurons.2009
Author(s)
Takemoto-Kimura S, Adachi-Morishima A, Ageta-Ishihara N, Suzuki K, Nonaka M, Okamura M, Nishimura VY, Kawauchi T, Nakajima K, Okuno H, Bito H.
Organizer
第39回北米神経科学学会年会
Place of Presentation
Chicago, USA. Poster
Year and Date
2009-10-19
Related Report
-
[Presentation] A pivotal role of a CaMKK-Cat+/calmodulin-dependent protein kinase I cascade in the radial migration of layer 2/3 cortical pyramidal neurons2009
Author(s)
Takemoto-Kimura S, Adachi-Morishima A, Ageta-Ishihara N, Suzuki K, Nonaka M, Okamura M, Nishimura VY, Kawauchi T, Nakajima K, Okuno H, Bito H
Organizer
第39回北米神経科学学会年会
Place of Presentation
Chicogo, USA
Year and Date
2009-10-19
Related Report
-
-
-
-
-
-
-