The analysis of NFκB regulation system

• Project/Area Number: 20790234
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: General medical chemistry
• Research Institution: Nagoya City University
• Principal Investigator: ASAMITSU Kaori Nagoya City University, 大学院・医学研究科, 助教 (20381783)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 生体分子医学 / NF-κB / 発現制御 / 転写 / NFκB

Research Abstract

Nuclear factor kB (NF-kB) is one of the critical transcription factors in inflammatory responses and cancer progression. In this study, we have identified FKBP4 as a binding partner of NF-kB p65 subunit and modified the NF-kB mediated transcription activity. FKBP4 is a binding protein to an immunosuppressive drug FK506 and known to involve with nuclear translocation. FKBP4 have enhanced NF-kB-dependent gene expression in combination with HSP90, suggesting that FKBP4 may be contributed to NF-kB translocation to the nucleus. The new regulation system of NF-kB via FKBP4 and HSP90 has been revealed.

Research Products

• [Journal Article] Inhibition of inflammatory cytokine production from rheumatoid synovial fibroblasts by a novel IκB kinase inhibitor. (2010)
  • Author(s): Tsuchiya, A., Imai, K., Asamitsu., K., Hibi, Y., Otsuka, T., Okamoto, T.
  • Journal Title: J Pharmacol Exp Ther (in press)
  • Peer Reviewed
• [Journal Article] Inhibition of inflammatory cytokine production from rheumatoid synovial fibroblasts by a novel IkappaB kinase inhibitor. (2010)
  • Author(s): Tsuchiya A, Imai K, Asamitsu K, Waguri-Nagaya Y, Otsuka T, Okamoto T.
  • Journal Title: J Pharmacol Exp Ther. 333 Pages: 236-243
  • Peer Reviewed
• [Journal Article] Inhibition of human immunodeficiency virus type 1 replication by blocking IkappaB kinase with noraristeromycin. (2008)
  • Author(s): Asamitsu, K, Yamaguchi, T., Nakata, K., Hibi, Y., Victoriano, A.F., Imai, K., Onozaki, K., Kitade, Y., Okamoto, T.
  • Journal Title: J Biochem. 144 Pages: 581-589
  • Peer Reviewed
• [Journal Article] Inhibition of human immunodeficiency virus type 1 replication by blockina IkannaB kinase with noraristeromvcin (2008)
  • Author(s): Asamitsu, et.al.
  • Journal Title: J Biochem 144 Pages: 581-589
  • Peer Reviewed
• [Presentation] Identification of an active ingredient on Inula helenium extracts for NF-kappa B inhibition (2009)
  • Author(s): Asamitsu, K., Ishibashi, T., Tanaka, K., Hibi. Y., Kobayashi. Y., Okamoto. T.
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: パシフィコ横山
  • Year and Date: 2009-12-09
• [Presentation] Identification of an active ingredient on Inula helenium extracts for NF-κB inhibition (2009)
  • Author(s): Asamitsu, et al
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜(横浜市)
  • Year and Date: 2009-12-09
• [Remarks]
  • URL: http://www.med.nagoya-cu.ac.jp/molgene.dir/index.Html