| Project/Area Number |
20790251
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Nagoya University |
|---|
Principal Investigator |
SATOSHI Kishida Nagoya University, 大学院・医学系研究科, 助教 (20402563)
|
|---|
| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 神経芽腫 / モデルマウス / ミッドカイン / 分子標的治療 / MYCN / Midkine / トランスジェニックマウス |
|---|
| Research Abstract |
We evaluated the novel therapeutic target of neuroblastoma, a pediatric solid tumor, in model mice. We showed that Midkine, the gene we identified before, was involved in the tumorigenesis of neuroblastoma, and could be an effective target for molecular therapy. On the other hand, we searched the other genes involved in neuroblastoma by comprehensive expression analysis, and identified some potent candidates.
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