A role of Nrf1 in the regulation of lipid metabolism

Research Project

Project/Area Number	20790252
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Pathological medical chemistry
Research Institution	Doshisha University
Principal Investigator	TSUCHIYA Yoshiki Doshisha University, 生命医科学部, 助教 (30456777)
Project Period (FY)	2008 – 2009
Project Status	Completed (Fiscal Year 2009)
Budget Amount *help	¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000) Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2008: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords	代謝異常学 / 脂質代謝 / シグナル伝達 / 蛋白質 / 脂質 / 転写因子
Research Abstract	To examine the physiological function of a transcription factor Nrf1 in the regulation of lipid metabolism, I tried to identify Nrf1-associated factors by using mass spectrometry. As a result, an E3 ubiquitin ligase subunit b-TrCP2 was identified. Further analyses revealed that b-TrCP2 regulates degradation of Nrf1 in the nucleus. These results provide a mechanistic insight into how Nrf1 is regulated to function in the target gene expression.

Report

(3 results)