A role of Nrf1 in the regulation of lipid metabolism
Project/Area Number |
20790252
|
Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Pathological medical chemistry
|
Research Institution | Doshisha University |
Principal Investigator |
TSUCHIYA Yoshiki Doshisha University, 生命医科学部, 助教 (30456777)
|
Project Period (FY) |
2008 – 2009
|
Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
|
Keywords | 代謝異常学 / 脂質代謝 / シグナル伝達 / 蛋白質 / 脂質 / 転写因子 |
Research Abstract |
To examine the physiological function of a transcription factor Nrf1 in the regulation of lipid metabolism, I tried to identify Nrf1-associated factors by using mass spectrometry. As a result, an E3 ubiquitin ligase subunit b-TrCP2 was identified. Further analyses revealed that b-TrCP2 regulates degradation of Nrf1 in the nucleus. These results provide a mechanistic insight into how Nrf1 is regulated to function in the target gene expression.
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Report
(3 results)
Research Products
(1 results)