Molecular basis of Nucleophosmin mutation in tumor
Project/Area Number |
20790257
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Pathological medical chemistry
|
Research Institution | Shimane University |
Principal Investigator |
SAKASHITA Gyosuke Shimane University, 医学部, 助教 (00397457)
|
Project Period (FY) |
2008 – 2009
|
Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | 分子病態学 / ヌクレオフォスミン / リン酸化 / 細胞周期 |
Research Abstract |
Aurora-B phosphorylates NPM1 on S293 and S143 in vitro. However, phosphorylation of S143 was not detected in vivo. Phosphorylation of NPM1 on S293 does not involve in it's subcellular localization, oligomerization and interaction with known NPM1 binding protein such as p19ARF or Nucleolin.
|
Report
(3 results)
Research Products
(7 results)