Study on endoplasmic reticulum stress response to novel blood glucose regulatory system and glucotoxicity in caloric restriction

• Project/Area Number: 20790260
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Pathological medical chemistry
• Research Institution: Nagasaki University
• Principal Investigator: YAMAZA Haruyoshi Nagasaki University, 大学病院, 講師 (30336151)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: カロリー制限 / 老化 / インスリンシグナル / 糖代謝

Research Abstract

To elucidate the effect of lifespan extension by caloric restriction (CR), endoplasmic reticulum (ER) stress response and FoxO1 were focused. In ES-TRAP mice, the response of ER stress trended to be reduced by CR. In FoxO1 knockout (ko) mice, the upregulation of gene expression related with cell cycle arrest and DNA repair by CR was inhibited under the oxidative stress condition. In addition, the antineoplastic effect of CR was abrogated in the ko-CR mice. These resulted suggested that FoxO1 is involved in the response for oxidative stress and antineoplastic effect by CR.

Research Products

• [Journal Article] Effect of ect of nsulin-like growth factors on lung development in a nitrofen-induced CDH rat model. (2011)
  • Author(s): Esumi G, Masumoto K, Teshiba R, Nagata K, Kinoshita Y, Yamaza H, Nonaka K, Taguchi T.
  • Journal Title: Pediatr Surg Int 27(2) Pages: 187-92
  • Peer Reviewed
• [Journal Article] Protogenin, a new member of the immunoglobulin superfamily, is implicated in the development of the mouse lower first molar. (2010)
  • Author(s): Takahashi KF, Kiyoshima T, Kobayashi I, Xie M, Yamaza H, Fujiwara H, Ookuma Y, Nagata K, Wada H, Sakai T, Terada Y, Sakai H.
  • Journal Title: BMC Dev Biol. 10 Pages: 115-115
  • Peer Reviewed
• [Journal Article] SIRT1 Regulates Thyroid-Stimulating Hormone Release by Enhancing PIP5Kgamma Activity through Deacetylation of Specific Lysine Residues in Mammals. (2010)
  • Author(s): Akieda-Asai S, Zaima N, Ikegami K, Kahyo T, Yao I, Hatanaka T, Iemura S, Sugiyama R, Yokozeki T, Eishi Y, Koike M, Ikeda K, Chiba T, Yamaza H, Shimokawa I, Song SY, Matsuno A, Mizutani A, Sawabe M, Chao MV, Tanaka M, Kanaho Y, Natsume T, Sugimura H, Date Y, McBurney MW, Guarente L, Setou M.
  • Journal Title: PLoS One 5(7)
  • Peer Reviewed
• [Journal Article] FoxO1 is involved in the antineoplastic effect of calorie restriction. (2010)
  • Author(s): Yamaza H, Komatsu T, Wakita S, Kijogi C, Park S, Hayashi H, Chiba T, Mori R, Furuyama T, Mori N, Shimokawa I.
  • Journal Title: Aging Cell 9(3) Pages: 372-782
  • NAID: 120006984942
  • Peer Reviewed
• [Journal Article] 口唇口蓋裂への対 (2010)
  • Author(s): 増田啓次, 山座治義, 山口登, 野中和明
  • Journal Title: 小児科臨床 63(11) Pages: 2281-2288
• [Journal Article] FoxO1 is involved in the antineoplastic effect of calorie restriction (2010)
  • Author(s): Haruyoshi Yamaza, et al.
  • Journal Title: Aging Cell Volume: 9-3 Pages: 372-382
  • NAID: 120006984942
  • Peer Reviewed
• [Journal Article] SIRT1 Regulates Thyroid-Stimulating Hormone Release by Enhancing PIP5Kγ Activity through Deacetylation of Specific Lysine Residues in Mammals (2010)
  • Author(s): Sayaka Akieda-Asai, et al
  • Journal Title: PLos One Volume: 5-7
  • Peer Reviewed
• [Journal Article] Effect of insulin-like growth factors on lung development in anitrofen-induced CDH rat model. (2010)
  • Author(s): Genshiro Esumi, et al
  • Journal Title: Pediatr Surg Int Volume: 27-2 Pages: 187-192
  • Peer Reviewed
• [Journal Article] Protogenin, a new member of the immunoglobulin superfamily, is implicated in the development of the mouse lower first molar (2010)
  • Author(s): Keiko F Takahashi, et al
  • Journal Title: BMC Dev Biol Volume: (In press)
  • Peer Reviewed
• [Journal Article] 口唇口蓋裂への対応 (2010)
  • Author(s): 増田啓次, 他
  • Journal Title: 小児臨床 Volume: 63-11 Pages: 2281-2288
• [Journal Article] Divergent regulation of adipose tissue metabolism by calorie restriction and inhibition of growth hormone signaling. (2009)
  • Author(s): Park S, Komatsu T, Hayashi H, Trindade LS, Yamaza H, Chiba T, Shimokawa I.
  • Journal Title: Exp Gerontol 44(10) Pages: 646-652
  • NAID: 120006983879
  • Peer Reviewed
• [Journal Article] Similar metabolic responses to calorie restriction in lean and obese Zucker rats. (2009)
  • Author(s): Chiba T, Komatsu T, Naykayama M, Adachi T, Tamashiro Y, Hayashi H, Yamaza, H, Higami Y, Shimokawa I.
  • Journal Title: Mol Cell Endocrinol 309(1-2) Pages: 17-25
  • Peer Reviewed
• [Journal Article] entification and characterization of an insulin receptor substrate 4-interacting protein in rat brain : Implications for longevity. (2009)
  • Author(s): Chiba T, Inoue D, Mizuno A, Komatsu T, Fujita S, Kubota H, Luisa Tagliaro M, Park S, Trindade LS, Hayashida T, Hayashi H, Yamaza H, Higami Y, Shimokawa I.
  • Journal Title: Neurobiol Aging 30(3) Pages: 474-482
  • Peer Reviewed
• [Journal Article] Divergent regulation of adipose tissue metabolism by calorie restriction and inhibition of growth hormone signaling. (2009)
  • Author(s): Seongjoon Park
  • Journal Title: Exp Gerontol 44 Pages: 646-652
  • Peer Reviewed
• [Journal Article] Similar metabolic responses to calorie restriction in lean and obese Zucker rats (2009)
  • Author(s): Takuya Chiba
  • Journal Title: Mol Cell Endocrinol 309 Pages: 17-25
  • Peer Reviewed
• [Journal Article] Calorie restriction initiated at a young age activates the -Glut4 pathway in rat white adipose tissue in an insulin-independent manner. (2008)
  • Author(s): Park S, Komatsu T, Hayashi H, Yamaza H, Chiba T, Hiagami Y, Shimokawa I.
  • Journal Title: Age 30(4) Pages: 293-302
  • Peer Reviewed
• [Journal Article] Longevity genes : insights from calorie restriction and genetic longevity models. (2008)
  • Author(s): Shimokawa I, Chiba T, Yamaza H., Komatsu T.
  • Journal Title: Mol Cell 26(5) Pages: 427-435
  • Peer Reviewed
• [Journal Article] Calorie restriction minimizes activation of insulin signaling in response to glucose : Potential involvement of the growth hormone-insulin-like growth factor 1 axis. (2008)
  • Author(s): Hayashi H, Yamaza H, Komatsu T, Park S, Chiba T, Higami Y, Nagayasu T, Shimokawa I.
  • Journal Title: Exp.Gerontol 43(9) Pages: 827-832
  • NAID: 120006981679
  • Peer Reviewed
• [Journal Article] Pituitary growth hormone suppression reduces resistin expression and enhances insulin effectiveness : relationship with caloric restriction. (2008)
  • Author(s): Chiba T, Yamaza H, Komatsu T, Nakayama M, Fujita S, Hayashi H, Higami Y, Shimokawa I.
  • Journal Title: Exp.Gerontol. 43(6) Pages: 595-600
  • Peer Reviewed
• [Journal Article] Manipulation of caloric content but not diet composition, attenuates the deficit in learning and memory of senescence-accelerated mouse strain P8. (2008)
  • Author(s): Komatsu T, Chiba T, Yamaza H, Yamashita K, Shimada A, Hoshiyama Y, Henmi T, Ohtani H, Higami Y, de Cabo R, Ingram DK, Shimokawa I.
  • Journal Title: Exp.Gerontol. 43(4) Pages: 339-346
  • Peer Reviewed
• [Journal Article] Glycolytic enzyme Pgk1 is strongly expressed in the developing tooth germ of the mouse lower first molar. (2008)
  • Author(s): Honda JY, Kobayashi I, Kiyoshima T, Yamaza H, Xie M, Tamahashi K, Enoki N, Nagata K, Nakashima A, Sakai H.
  • Journal Title: Histol.Histopathol. 23(4) Pages: 423-432
  • Peer Reviewed
• [Journal Article] メタボリックシンドロームとカロリー制限:糖代謝を中心に (2008)
  • Author(s): 山座治義, 千葉卓哉, 下川功
  • Journal Title: 新しい眼科学 25(1) Pages: 9-14
  • NAID: 10022616733
• [Journal Article] カロリー制限による寿命延長・抗老化機構-神経内分泌仮説に基づく代謝調節の重要性- (2008)
  • Author(s): 千葉卓哉, 山座治義, 下川功
  • Journal Title: 基礎老化研究 32(3) Pages: 15-20
  • NAID: 10024377776
• [Journal Article] Calorie restriction initiated at a young age activates the Akt/PKCCζ/λ-Glut4 pathway in rat white adipose tissue in an insulin-independent manner (2008)
  • Author(s): Seongjoon Park
  • Journal Title: Age 30 Pages: 293-302
  • Peer Reviewed
• [Journal Article] Calorie restriction minimizes activation of insulin signaling in response to glucose : potential involvement of the growth hormone-insulin-like growth factor 1 axis (2008)
  • Author(s): Hiroko Hayashi
  • Journal Title: Experimental Gerontology 43 Pages: 827-832
  • Peer Reviewed
• [Journal Article] カロリーリストリクション仮説と抗老化医学への応用 (2008)
  • Author(s): 山座治義
  • Journal Title: 眼科プラクティス 22 Pages: 189-202
• [Journal Article] メタボリックシンドロームとカロリー制限 : 糖代謝を中心に (2008)
  • Author(s): 山座治義
  • Journal Title: 新しい眼科 25 Pages: 9-14
  • NAID: 10022616733
• [Presentation] Immunomodulatory Properties of Stem Cells from Human Supernumerary Teeth. (2011)
  • Author(s): Yusuke Makino, et al
  • Organizer: 89th IADR
  • Place of Presentation: サンディエゴ(米国)
  • Year and Date: 2011-03-17
• [Presentation] Immunomodulatory Properties of Stem Cells from Human Supernumerary Teeth. (2011)
  • Author(s): Makino Y, Yamaza T, Yamaza H, Akiyama K, Kido M, Nonaka K, Terada T, Shi S, Kukita T.
  • Organizer: 89th IADR
  • Place of Presentation: San Diego, USA
• [Presentation] 腹7分目の健康科学 (2010)
  • Author(s): 山座治義
  • Organizer: 第28回日本小児歯科学会九州地方会大会
  • Place of Presentation: 福岡県歯科医師会館(福岡市)
  • Year and Date: 2010-10-03
• [Presentation] ヒト上顎正中過剰埋伏歯の歯髄由来間葉系幹細胞の単離とその免疫調節能の解析 (2010)
  • Author(s): 牧野友祐, 他
  • Organizer: 第52回歯科基礎医学会総会
  • Place of Presentation: タワーホール船堀(東京)
  • Year and Date: 2010-09-21
• [Presentation] 全身性エリテマトーデスに対する乳歯歯髄幹細胞の再生医療学的応用 (2010)
  • Author(s): 山座孝義, 他
  • Organizer: 第52回歯科基礎医学会総会
  • Place of Presentation: タワーホール船堀(東京)
  • Year and Date: 2010-09-21
• [Presentation] Functionalimplication of Thymosin beta 4 in the tooth development. (2010)
  • Author(s): Yukiko Ookuma, et al
  • Organizer: 88th IADR
  • Place of Presentation: バルセロナ(スペイン)
  • Year and Date: 2010-07-15
• [Presentation] アラジール症候群の患児に対する歯科治療の2例 (2010)
  • Author(s): 山座治義, 他
  • Organizer: 第48回日本小児歯科学会大会
  • Place of Presentation: 名古屋国際会議場(名古屋)
  • Year and Date: 2010-05-20
• [Presentation] 歯冠周囲に歯原性線維腫を認めた埋伏上顎中切歯を牽引誘導した1例 (2010)
  • Author(s): 中村由紀, 他
  • Organizer: 第48回日本小児歯科学会大会
  • Place of Presentation: 名古屋国際会議場(名古屋)
  • Year and Date: 2010-05-20
• [Presentation] 生体肝移植を予定された患児に重症の齲蝕を認めたため術前に多数歯を抜去した1例 (2010)
  • Author(s): 増田啓次, 他
  • Organizer: 第48回日本小児歯科学会大会
  • Place of Presentation: 名古屋国際会議場(名古屋)
  • Year and Date: 2010-05-20
• [Presentation] FoxO1転写因子は,カロリー制限のストレス応答,抗腫瘍効果に関与する (2010)
  • Author(s): 山座治義, 他
  • Organizer: 第99回日本病理学会総会
  • Place of Presentation: 京王プラザ(東京)
  • Year and Date: 2010-04-29
• [Presentation] 腹7分目の健康科学 (2010)
  • Author(s): 山座治義
  • Organizer: 第28回日本小児歯科学会九州地方会大会
  • Place of Presentation: 福岡
• [Presentation] 全身性エリテマトーデスに対する乳歯歯髄幹細胞の再生医療学的応用 (2010)
  • Author(s): 山座孝義, 山座治義, 牧野友祐, 城戸瑞穂, 野中和明, 久木田敏男
  • Organizer: 第52回歯科基礎医学会総会
  • Place of Presentation: 東京
• [Presentation] ヒト上顎正中過剰埋伏歯の歯髄由来間葉系幹細胞の単離とその免疫調節能の解析 (2010)
  • Author(s): 牧野友祐, 山座孝義, 山座治義, 城戸瑞穂, 野中和明, 寺田善博, 久木田敏男
  • Organizer: 第52回歯科基礎医学会総会
  • Place of Presentation: 東京
• [Presentation] Functional implication of Thymosin beta 4 in the tooth development. (2010)
  • Author(s): Ookuma Y, Kobayashi I, Kiyoshima T, Nagata K, Fujiwara H, Yamaza H, Nonaka K, Sakai H.
  • Organizer: 88th IADR General Session
  • Place of Presentation: Barcelona, Spain
• [Presentation] アラジール症候群の患児に対する歯科治療の2例 (2010)
  • Author(s): 山座治義, 中村由紀, 増田啓次, 山口登, 野中和明
  • Organizer: 第48回日本小児歯科学会大会
  • Place of Presentation: 名古屋
• [Presentation] 歯冠周囲に歯原性線維腫を認めた埋伏上顎中切歯を牽引誘導した1例 (2010)
  • Author(s): 中村由紀, 増田啓次, 山口登, 山座治義, 野中和明
  • Organizer: 第48回日本小児歯科学会大会
  • Place of Presentation: 名古屋
• [Presentation] 生体肝移植を予定された患児に重症の齲蝕を認めたため術前に多数歯を抜去した1例 (2010)
  • Author(s): 増田啓次, 山口登, 中村由紀, 山座治義, 野中和明
  • Organizer: 第48回日本小児歯科学会大会
  • Place of Presentation: 名古屋
• [Presentation] FoxO1転写因子はカロリー制限のストレス応答,抗腫瘍効果に関与する (2010)
  • Author(s): 山座治義, 小松利光, 森亮一, 林洋子, 千葉卓哉, 古山達雄, 下川功
  • Organizer: 第99回日本病理学会総会
  • Place of Presentation: 東京
• [Presentation] Mouse mandible contains distinctive mesenchymal stem cells (2009)
  • Author(s): Takayoshi Yamaza
  • Organizer: 32nd Annual Meeting and Scientific Symposium
  • Place of Presentation: ホノルル(米国ハワイ州)
  • Year and Date: 2009-10-20
• [Presentation] TISSUE-SPECIFIC VARIATION OF INSULIN SIGNAL IN CALORIC RESTRICTION (2009)
  • Author(s): Haruyoshi Yamaza
  • Organizer: he American Aging Association 38th Annual Meeting
  • Place of Presentation: スコッツデール(米国アリゾナ州)
  • Year and Date: 2009-06-01
• [Presentation] カロリー制限におけるFoxO1転写因子の役割 (2009)
  • Author(s): 山座治義
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2009-05-03
• [Presentation] 開口障害を伴うガードナー症候群の一例 (2009)
  • Author(s): 山座治義, 増田啓次, 中村由紀, 平野克枝, 山口登, 祐田京子, 野中和明
  • Organizer: 第27回日本小児歯科学会九州地方会
  • Place of Presentation: 北九州
• [Presentation] ウイリアムズ症候群患児に見られた歯科的特徴 (2009)
  • Author(s): 山口登, 増田啓次, 山座治義, 中村由紀, 祐田京子, 野中和明
  • Organizer: 第27回日本小児歯科学会九州地方会
  • Place of Presentation: 北九州
• [Presentation] 当小児歯科外来での脳性麻痺患者の9年間にわたる口腔管理 (2009)
  • Author(s): 立野麗子, 山口登, 増田啓次, 中村由紀, 山座治義, 馬場史子, 野中和明
  • Organizer: 第26回日本障害者歯科学会総会
  • Place of Presentation: 名古屋
• [Presentation] Mouse mandible contains distinctive mesenchymal stem cells. (2009)
  • Author(s): Yamaza T, Ren G, Akiyama K, Yamaza H, Nonaka K, Shi Y, Shi S.
  • Organizer: 32nd Annual Meeting and Scientific Symposium
  • Place of Presentation: Honolulu, USA
• [Presentation] マウス顎骨由来間葉系幹細胞の単離と特性解析 (2009)
  • Author(s): 山座孝義, 山座治義, 野中和明, 城戸瑞穂
  • Organizer: 第51回歯科基礎医学会総会
  • Place of Presentation: 新潟
• [Presentation] Diets modulate frequencies of subsets of progenitor's stem cells in mouse bone marrow. (2009)
  • Author(s): Trindade LS, Nagata K, Yamaza H, Chiba T, Shimokawa I.
  • Organizer: 第32回日本基礎老化学会
  • Place of Presentation: 横浜
• [Presentation] ROLE OF HYOTHALAMIC NEUROPEPTIDE Y IN THE BENEFICIAL EFFECTS OF CALORIE RESTRICTION. (2009)
  • Author(s): Chiba T, Yamaza H, Shimokawa I.
  • Organizer: XIXth IAGG World Congress of Gerontology and Geriatrics
  • Place of Presentation: Paris, France
• [Presentation] A POTENTIAL ROLE FOR FOXO1 IN THE EFFECT OF CALORIE RESTRICTION. (2009)
  • Author(s): Isao S, Yamaza H, Komatsu T, Chiba T, Hayashi H, Furuyama T, Honda I, Shimokawa I.
  • Organizer: XIXth IAGG World Congress of Gerontology and Geriatrics
  • Place of Presentation: Paris, France
• [Presentation] カロリー制限による代謝の変化におけるneuropeptideYの重要性 (2009)
  • Author(s): 千葉卓哉, 小松利光, 林洋子, 山座治義, 樋上賀一, 下川功
  • Organizer: 第32回日本基礎老化学会
  • Place of Presentation: 横浜
• [Presentation] 脂肪特異的ノックアウトマウス脂肪組織における長期カロリー制限にともなう遺伝子発現プロフィール (2009)
  • Author(s): 岡崎達哉, 沖田直之, 山座治義, 千葉卓哉, 下川功, 樋上賀一
  • Organizer: 第32回日本基礎老化学会
  • Place of Presentation: 横浜
• [Presentation] カロリー制限時の白色脂肪組織におけるSrebp1支配遺伝子発現変動の網羅的解析 (2009)
  • Author(s): 仲條良和, 沖田直之, 伊藤麻希子, 鈴木智典, 宮崎智, 山座治義, 千葉卓哉, 下川功, 樋上賀一
  • Organizer: 第32回日本基礎老化学会
  • Place of Presentation: 横浜
• [Presentation] TISSUE-SPECIFIC VARIATION OF INSULIN SIGNAL IN CALORIC RESTRICTION. (2009)
  • Author(s): Yamaza H, Park S, Chiba T, Nonaka K, Shimokawa I.
  • Organizer: The American Aging Association 38th Annual Meeting
  • Place of Presentation: Scottsdale, USA
• [Presentation] カロリー制限におけるFoxO1転写因子の役割 (2009)
  • Author(s): 山座治義, 小松利光, 千葉卓哉, 林洋子, 下川功
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 京都
• [Presentation] Calorie restriction-specific adipose tissue metabolic profile : different from the effect of growth hormone suppression (2008)
  • Author(s): Seongjoon Park
  • Organizer: The 9th International Congress on Cell Biology
  • Place of Presentation: ソウル(韓国)
  • Year and Date: 2008-10-07
• [Presentation] Calorie restriction disrupts hepatic insulin signal transduction in mice (2008)
  • Author(s): Haruyoshi Yamaza
  • Organizer: The Japan-Korea Joint Seminar(AACL2008)-To ward the establishment of Asian Aging Research and Education Center
  • Place of Presentation: ハウステンボス(長崎県佐世保)
  • Year and Date: 2008-09-05
• [Presentation] Calorie restriction-specific adipose tissue metabolic profile : difference from the, effect of growth hormone suppression (2008)
  • Author(s): Seongjoon Park
  • Organizer: The Japan-Korea Joint Seminar(AACL2008)-To ward the establishment of Asian Aging Research and Education Center
  • Place of Presentation: ハウステンボス(長崎県佐世保)
  • Year and Date: 2008-09-05
• [Presentation] A role for FoxO1 in the effect of calorie restriction on oxidative stress and lifespan (2008)
  • Author(s): Calorine Kijogi
  • Organizer: The Japan-Korea Joint Seminar(AACL2008)-To ward the establishment of Asian. Aging Research and Education Center
  • Place of Presentation: ハウステンボス(長崎県佐世保)
  • Year and Date: 2008-09-05
• [Presentation] Caloric restriction upregulates the Akt-Glut pathway in the white adipose tissue possibly through moderate suppression of growth hormone (2008)
  • Author(s): Seongjoon Park
  • Organizer: 第31回日本基礎老化学会
  • Place of Presentation: 松本
  • Year and Date: 2008-06-13
• [Presentation] Does moderate suppression of growth hormone axis mimic the effect of caloric restriction on the insulin signaling in the white adipose tissue? (2008)
  • Author(s): Seongjoon Park
  • Organizer: American Aging Association-37th Annual Meeting
  • Place of Presentation: ボルダー(米国コロラド州)
  • Year and Date: 2008-06-01
• [Presentation] Calorie restriction disrupts hepatic insulin signal transduction in mice (2008)
  • Author(s): Haruyoshi Yamaza
  • Organizer: 2008 Spring Conference of the Korean Society for Gerontology and AVDRC symposium
  • Place of Presentation: デグ(韓国)
  • Year and Date: 2008-05-16
• [Presentation] カロリー制限に対する代謝の応答はインスリンおよびレプチン抵抗性を示す肥満ラットにおいても起こる (2008)
  • Author(s): 千葉卓哉, 小松利光, 中山正彦, 足立利幸, 林洋子, 山座治義, 樋上賀一, 下川功
  • Organizer: 第31回日本分子生物学会年会
  • Place of Presentation: 神戸
• [Presentation] Longevity genes. (2008)
  • Author(s): Shimokawa I, Chiba T, Yamaza H, Komatsu T.
  • Organizer: The 10th International Symposium on Vascular Aging : molecular exploration and micro-inflammatory implications.
  • Place of Presentation: Busan, Korea
• [Presentation] Calorie restriction-specific adipose tissue metabolic profile : different from the effect of growth hormone suppression. (2008)
  • Author(s): Park S, Komatsu T, Hayashi H, Trindade LS, Yamaza H, Chiba T, Shimokawa I.
  • Organizer: The 9th International Congress on Cell Biology
  • Place of Presentation: Seoul, Korea
• [Presentation] 老化促進モデルマウスSAMP8の学習記憶能における食餌成分およびカロリー制限の影響 (2008)
  • Author(s): 千葉卓哉, 小松利光, 山座治義, 山下樹三裕, 島田厚良, 樋上賀一, de Cabo R., Ingram D.K., 下川功
  • Organizer: 第51回日本神経化学会
  • Place of Presentation: 富山
• [Presentation] Calorie restriction increases TORC2-dependent CREB activity for induction of gluconeogenetic gene expression by down-regulation of AMPK. (2008)
  • Author(s): Trindade LS, Park S, Komatsu T, Yamaza H, Chiba T, Higami Y, Shimokawa I.
  • Organizer: The 9th International Congress on Cell Biology
  • Place of Presentation: Seoul, Korea
• [Presentation] Identification and characterization of food deprivation-activated genes and insulin receptor substrate interacting protein. (2008)
  • Author(s): Chiba T, Yamaza H, Shimokawa I.
  • Organizer: The Japan-Korea Joint Seminar (AACL2008)-Toward the establishment of Asian Aging Research and Education Center
  • Place of Presentation: Huis Ten Bosch, Japan
• [Presentation] Calorie restriction disrupts hepatic insulin signal transduction in mice. (2008)
  • Author(s): Yamaza H, Park S, Chiba T, Shimokawa I.
  • Organizer: The Japan-Korea Joint Seminar (AACL2008)-Toward the establishment of Asian Aging Research and Education Center
  • Place of Presentation: Huis Ten Bosch, Japan
• [Presentation] Calorie restriction-specific adipose tissue metabolic profile : difference from the effect of growth hormone suppression. (2008)
  • Author(s): Park S, Komatsu T, Hayashi H, Trindade LS, Yamaza H, Chiba T, Shimokawa I.
  • Organizer: The Japan-Korea Joint Seminar (AACL2008)-Toward the establishment of Asian Aging Research and Education Center
  • Place of Presentation: Huis Ten Bosch, Japan
• [Presentation] Does a high fat diet inhibit mobilization of bone marrow (BM) progenitor stem cells (2008)
  • Author(s): Trindade LS, Nagai K, Park S, Chiba T, Yamaza H, Shimokawa I.
  • Organizer: The Japan-Korea Joint Seminar (AACL2008)-Toward the establishment of Asian Aging Research and Education Center
  • Place of Presentation: Huis Ten Bosch, Japan
• [Presentation] A role for FoxO1 in the effect of calorie restriction on oxidative stress and lifespan. (2008)
  • Author(s): Kijogi C, Komatsu T, Furuyama T, Chiba T, Yamaza H, Shimokawa I.
  • Organizer: The Japan-Korea Joint Seminar (AACL2008)-Toward the establishment of Asian Aging Research and Education Center
  • Place of Presentation: Huis Ten Bosch, Japan
• [Presentation] Calorie restriction increases TORC2-dependent CREB activity for induction of gluconeogenetic gene expression by down-regulation of AMPK. (2008)
  • Author(s): Trindade LS, Komatsu T, Yamaza H, Chiba T, Higami Y, Shimokawa I.
  • Organizer: 第31回日本基礎老化学会
  • Place of Presentation: 松本
• [Presentation] Caloric restriction upregulates the Akt-Glut pathway in the white adipose tissue possibly through moderate suppression of growth hormone. (2008)
  • Author(s): Park S, Komatsu T, Hayashi H, Yamaza H, Chiba T, Higami Y, Shimokawa I.
  • Organizer: 第31回日本基礎老化学会
  • Place of Presentation: 松本
• [Presentation] GH/IGF-I系の抑制は白色脂肪組織におけるresistin発現を減少させ血糖値を低下させる (2008)
  • Author(s): 千葉卓哉, 山座治義, 小松利光, 中山正彦, 藤田智, 林洋子, 樋上賀一, 下川功
  • Organizer: 第31回日本基礎老化学会
  • Place of Presentation: 松本
• [Presentation] FoxOファミリーの細胞内局在におけるカロリー制限の影響 (2008)
  • Author(s): 山座治義, 朴盛浚, 千葉卓哉, 小松利光, 下川功
  • Organizer: 第31回日本基礎老化学会
  • Place of Presentation: 松本
• [Presentation] Does moderate suppression of growth hormone axis mimic the effect of caloric restriction on the insulin signaling in the white adipose tissue (2008)
  • Author(s): Park S, Komatsu T, Hayashi H, Yamaza H, Chiba T, Higami Y, Shimokawa I.
  • Organizer: The American Aging Association 37th Annual Meeting
  • Place of Presentation: Bouldar, USA
• [Presentation] Role of FoxO1 in Caloric Restriction. (2008)
  • Author(s): Yamaza H, Park S, Chiba T, Shimokawa I.
  • Organizer: The 8th Korea-Japan Gerontologist Joint Meeting, 2008 Spring Conference of the Korean Society for Gerontology and AVDRC symposium
  • Place of Presentation: Daegu, Korea
• [Presentation] 白色脂肪組織におけるカロリー制限によるアセチル化,脱アセチル化酵素発現の変化とその標的タンパク (2008)
  • Author(s): 樋上賀一, 千葉卓哉, 山座治義, 戸田年総, 下川功
  • Organizer: 第97回日本病理学会総会
  • Place of Presentation: 金沢
• [Book] 小児歯科学第4版(高木裕三, 他 編) (2011)
  • Author(s): 山座治義, 野中和明
  • Publisher: 医歯薬出版株式会社
• [Book] 小児歯科学 (2011)
  • Author(s): 山座治義, 他
  • Publisher: 医歯薬出版株式会社
• [Book] 抗加齢眼科学(眼科プラクティス)(坪田一男 編) 22 (2008)
  • Author(s): 山座治義, 下川功
  • Publisher: 文光堂
• [Book] Handbook on Immunosenescence(Fulop T et al., eds.)(A transgenic dwarf rat strain as a tool for the study of immunosenescence in aging rats and the effect of calorie restriction) (2008)
  • Author(s): Shimokawa I, Utsuyama M, Komatsu T, Yamaza H, Chiba T.
  • Publisher: Springer Science+ Business
• [Book] 小児科学第10版(五十嵐隆編)
  • Author(s): 山座治義, 野中和明
  • Publisher: 文光堂(印刷中)
• [Book] サイエンスに基づいたアンチエイジング(坪田一男, 門脇孝,編)
  • Author(s): 山座治義, 千葉卓哉, 下川功
  • Publisher: メディカルレビュー社(印刷中)
• [Book] 老化・老年病研究のための動物実験ガイドブック(基礎老化学会 編)2008
  • Author(s): 千葉卓哉, 山座治義, 下川功
  • Publisher: アドスリー