• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Study on endoplasmic reticulum stress response to novel blood glucose regulatory system and glucotoxicity in caloric restriction

Research Project

Project/Area Number 20790260
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Pathological medical chemistry
Research InstitutionNagasaki University

Principal Investigator

YAMAZA Haruyoshi  Nagasaki University, 大学病院, 講師 (30336151)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsカロリー制限 / 老化 / インスリンシグナル / 糖代謝
Research Abstract

To elucidate the effect of lifespan extension by caloric restriction (CR), endoplasmic reticulum (ER) stress response and FoxO1 were focused. In ES-TRAP mice, the response of ER stress trended to be reduced by CR. In FoxO1 knockout (ko) mice, the upregulation of gene expression related with cell cycle arrest and DNA repair by CR was inhibited under the oxidative stress condition. In addition, the antineoplastic effect of CR was abrogated in the ko-CR mice. These resulted suggested that FoxO1 is involved in the response for oxidative stress and antineoplastic effect by CR.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (92 results)

All 2011 2010 2009 2008 Other

All Journal Article (27 results) (of which Peer Reviewed: 21 results) Presentation (58 results) Book (7 results)

  • [Journal Article] Effect of ect of nsulin-like growth factors on lung development in a nitrofen-induced CDH rat model.2011

    • Author(s)
      Esumi G, Masumoto K, Teshiba R, Nagata K, Kinoshita Y, Yamaza H, Nonaka K, Taguchi T.
    • Journal Title

      Pediatr Surg Int 27(2)

      Pages: 187-92

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Protogenin, a new member of the immunoglobulin superfamily, is implicated in the development of the mouse lower first molar.2010

    • Author(s)
      Takahashi KF, Kiyoshima T, Kobayashi I, Xie M, Yamaza H, Fujiwara H, Ookuma Y, Nagata K, Wada H, Sakai T, Terada Y, Sakai H.
    • Journal Title

      BMC Dev Biol. 10

      Pages: 115-115

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] SIRT1 Regulates Thyroid-Stimulating Hormone Release by Enhancing PIP5Kgamma Activity through Deacetylation of Specific Lysine Residues in Mammals.2010

    • Author(s)
      Akieda-Asai S, Zaima N, Ikegami K, Kahyo T, Yao I, Hatanaka T, Iemura S, Sugiyama R, Yokozeki T, Eishi Y, Koike M, Ikeda K, Chiba T, Yamaza H, Shimokawa I, Song SY, Matsuno A, Mizutani A, Sawabe M, Chao MV, Tanaka M, Kanaho Y, Natsume T, Sugimura H, Date Y, McBurney MW, Guarente L, Setou M.
    • Journal Title

      PLoS One 5(7)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] FoxO1 is involved in the antineoplastic effect of calorie restriction.2010

    • Author(s)
      Yamaza H, Komatsu T, Wakita S, Kijogi C, Park S, Hayashi H, Chiba T, Mori R, Furuyama T, Mori N, Shimokawa I.
    • Journal Title

      Aging Cell 9(3)

      Pages: 372-782

    • NAID

      120006984942

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 口唇口蓋裂への対2010

    • Author(s)
      増田啓次, 山座治義, 山口登, 野中和明
    • Journal Title

      小児科臨床 63(11)

      Pages: 2281-2288

    • Related Report
      2010 Final Research Report
  • [Journal Article] FoxO1 is involved in the antineoplastic effect of calorie restriction2010

    • Author(s)
      Haruyoshi Yamaza, et al.
    • Journal Title

      Aging Cell

      Volume: 9-3 Pages: 372-382

    • NAID

      120006984942

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] SIRT1 Regulates Thyroid-Stimulating Hormone Release by Enhancing PIP5Kγ Activity through Deacetylation of Specific Lysine Residues in Mammals2010

    • Author(s)
      Sayaka Akieda-Asai, et al
    • Journal Title

      PLos One

      Volume: 5-7

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of insulin-like growth factors on lung development in anitrofen-induced CDH rat model.2010

    • Author(s)
      Genshiro Esumi, et al
    • Journal Title

      Pediatr Surg Int

      Volume: 27-2 Pages: 187-192

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Protogenin, a new member of the immunoglobulin superfamily, is implicated in the development of the mouse lower first molar2010

    • Author(s)
      Keiko F Takahashi, et al
    • Journal Title

      BMC Dev Biol

      Volume: (In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 口唇口蓋裂への対応2010

    • Author(s)
      増田啓次, 他
    • Journal Title

      小児臨床

      Volume: 63-11 Pages: 2281-2288

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Divergent regulation of adipose tissue metabolism by calorie restriction and inhibition of growth hormone signaling.2009

    • Author(s)
      Park S, Komatsu T, Hayashi H, Trindade LS, Yamaza H, Chiba T, Shimokawa I.
    • Journal Title

      Exp Gerontol 44(10)

      Pages: 646-652

    • NAID

      120006983879

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Similar metabolic responses to calorie restriction in lean and obese Zucker rats.2009

    • Author(s)
      Chiba T, Komatsu T, Naykayama M, Adachi T, Tamashiro Y, Hayashi H, Yamaza, H, Higami Y, Shimokawa I.
    • Journal Title

      Mol Cell Endocrinol 309(1-2)

      Pages: 17-25

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] entification and characterization of an insulin receptor substrate 4-interacting protein in rat brain : Implications for longevity.2009

    • Author(s)
      Chiba T, Inoue D, Mizuno A, Komatsu T, Fujita S, Kubota H, Luisa Tagliaro M, Park S, Trindade LS, Hayashida T, Hayashi H, Yamaza H, Higami Y, Shimokawa I.
    • Journal Title

      Neurobiol Aging 30(3)

      Pages: 474-482

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Divergent regulation of adipose tissue metabolism by calorie restriction and inhibition of growth hormone signaling.2009

    • Author(s)
      Seongjoon Park
    • Journal Title

      Exp Gerontol 44

      Pages: 646-652

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Similar metabolic responses to calorie restriction in lean and obese Zucker rats2009

    • Author(s)
      Takuya Chiba
    • Journal Title

      Mol Cell Endocrinol 309

      Pages: 17-25

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Calorie restriction initiated at a young age activates the -Glut4 pathway in rat white adipose tissue in an insulin-independent manner.2008

    • Author(s)
      Park S, Komatsu T, Hayashi H, Yamaza H, Chiba T, Hiagami Y, Shimokawa I.
    • Journal Title

      Age 30(4)

      Pages: 293-302

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Longevity genes : insights from calorie restriction and genetic longevity models.2008

    • Author(s)
      Shimokawa I, Chiba T, Yamaza H., Komatsu T.
    • Journal Title

      Mol Cell 26(5)

      Pages: 427-435

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Calorie restriction minimizes activation of insulin signaling in response to glucose : Potential involvement of the growth hormone-insulin-like growth factor 1 axis.2008

    • Author(s)
      Hayashi H, Yamaza H, Komatsu T, Park S, Chiba T, Higami Y, Nagayasu T, Shimokawa I.
    • Journal Title

      Exp.Gerontol 43(9)

      Pages: 827-832

    • NAID

      120006981679

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pituitary growth hormone suppression reduces resistin expression and enhances insulin effectiveness : relationship with caloric restriction.2008

    • Author(s)
      Chiba T, Yamaza H, Komatsu T, Nakayama M, Fujita S, Hayashi H, Higami Y, Shimokawa I.
    • Journal Title

      Exp.Gerontol. 43(6)

      Pages: 595-600

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Manipulation of caloric content but not diet composition, attenuates the deficit in learning and memory of senescence-accelerated mouse strain P8.2008

    • Author(s)
      Komatsu T, Chiba T, Yamaza H, Yamashita K, Shimada A, Hoshiyama Y, Henmi T, Ohtani H, Higami Y, de Cabo R, Ingram DK, Shimokawa I.
    • Journal Title

      Exp.Gerontol. 43(4)

      Pages: 339-346

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Glycolytic enzyme Pgk1 is strongly expressed in the developing tooth germ of the mouse lower first molar.2008

    • Author(s)
      Honda JY, Kobayashi I, Kiyoshima T, Yamaza H, Xie M, Tamahashi K, Enoki N, Nagata K, Nakashima A, Sakai H.
    • Journal Title

      Histol.Histopathol. 23(4)

      Pages: 423-432

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] メタボリックシンドロームとカロリー制限:糖代謝を中心に2008

    • Author(s)
      山座治義, 千葉卓哉, 下川功
    • Journal Title

      新しい眼科学 25(1)

      Pages: 9-14

    • NAID

      10022616733

    • Related Report
      2010 Final Research Report
  • [Journal Article] カロリー制限による寿命延長・抗老化機構-神経内分泌仮説に基づく代謝調節の重要性-2008

    • Author(s)
      千葉卓哉, 山座治義, 下川功
    • Journal Title

      基礎老化研究 32(3)

      Pages: 15-20

    • NAID

      10024377776

    • Related Report
      2010 Final Research Report
  • [Journal Article] Calorie restriction initiated at a young age activates the Akt/PKCCζ/λ-Glut4 pathway in rat white adipose tissue in an insulin-independent manner2008

    • Author(s)
      Seongjoon Park
    • Journal Title

      Age 30

      Pages: 293-302

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Calorie restriction minimizes activation of insulin signaling in response to glucose : potential involvement of the growth hormone-insulin-like growth factor 1 axis2008

    • Author(s)
      Hiroko Hayashi
    • Journal Title

      Experimental Gerontology 43

      Pages: 827-832

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] カロリーリストリクション仮説と抗老化医学への応用2008

    • Author(s)
      山座治義
    • Journal Title

      眼科プラクティス 22

      Pages: 189-202

    • Related Report
      2008 Annual Research Report
  • [Journal Article] メタボリックシンドロームとカロリー制限 : 糖代謝を中心に2008

    • Author(s)
      山座治義
    • Journal Title

      新しい眼科 25

      Pages: 9-14

    • NAID

      10022616733

    • Related Report
      2008 Annual Research Report
  • [Presentation] Immunomodulatory Properties of Stem Cells from Human Supernumerary Teeth.2011

    • Author(s)
      Yusuke Makino, et al
    • Organizer
      89th IADR
    • Place of Presentation
      サンディエゴ(米国)
    • Year and Date
      2011-03-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Immunomodulatory Properties of Stem Cells from Human Supernumerary Teeth.2011

    • Author(s)
      Makino Y, Yamaza T, Yamaza H, Akiyama K, Kido M, Nonaka K, Terada T, Shi S, Kukita T.
    • Organizer
      89th IADR
    • Place of Presentation
      San Diego, USA
    • Related Report
      2010 Final Research Report
  • [Presentation] 腹7分目の健康科学2010

    • Author(s)
      山座治義
    • Organizer
      第28回日本小児歯科学会九州地方会大会
    • Place of Presentation
      福岡県歯科医師会館(福岡市)
    • Year and Date
      2010-10-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] ヒト上顎正中過剰埋伏歯の歯髄由来間葉系幹細胞の単離とその免疫調節能の解析2010

    • Author(s)
      牧野友祐, 他
    • Organizer
      第52回歯科基礎医学会総会
    • Place of Presentation
      タワーホール船堀(東京)
    • Year and Date
      2010-09-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] 全身性エリテマトーデスに対する乳歯歯髄幹細胞の再生医療学的応用2010

    • Author(s)
      山座孝義, 他
    • Organizer
      第52回歯科基礎医学会総会
    • Place of Presentation
      タワーホール船堀(東京)
    • Year and Date
      2010-09-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] Functionalimplication of Thymosin beta 4 in the tooth development.2010

    • Author(s)
      Yukiko Ookuma, et al
    • Organizer
      88th IADR
    • Place of Presentation
      バルセロナ(スペイン)
    • Year and Date
      2010-07-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] アラジール症候群の患児に対する歯科治療の2例2010

    • Author(s)
      山座治義, 他
    • Organizer
      第48回日本小児歯科学会大会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Year and Date
      2010-05-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] 歯冠周囲に歯原性線維腫を認めた埋伏上顎中切歯を牽引誘導した1例2010

    • Author(s)
      中村由紀, 他
    • Organizer
      第48回日本小児歯科学会大会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Year and Date
      2010-05-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] 生体肝移植を予定された患児に重症の齲蝕を認めたため術前に多数歯を抜去した1例2010

    • Author(s)
      増田啓次, 他
    • Organizer
      第48回日本小児歯科学会大会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Year and Date
      2010-05-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] FoxO1転写因子は,カロリー制限のストレス応答,抗腫瘍効果に関与する2010

    • Author(s)
      山座治義, 他
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      京王プラザ(東京)
    • Year and Date
      2010-04-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] 腹7分目の健康科学2010

    • Author(s)
      山座治義
    • Organizer
      第28回日本小児歯科学会九州地方会大会
    • Place of Presentation
      福岡
    • Related Report
      2010 Final Research Report
  • [Presentation] 全身性エリテマトーデスに対する乳歯歯髄幹細胞の再生医療学的応用2010

    • Author(s)
      山座孝義, 山座治義, 牧野友祐, 城戸瑞穂, 野中和明, 久木田敏男
    • Organizer
      第52回歯科基礎医学会総会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Presentation] ヒト上顎正中過剰埋伏歯の歯髄由来間葉系幹細胞の単離とその免疫調節能の解析2010

    • Author(s)
      牧野友祐, 山座孝義, 山座治義, 城戸瑞穂, 野中和明, 寺田善博, 久木田敏男
    • Organizer
      第52回歯科基礎医学会総会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Presentation] Functional implication of Thymosin beta 4 in the tooth development.2010

    • Author(s)
      Ookuma Y, Kobayashi I, Kiyoshima T, Nagata K, Fujiwara H, Yamaza H, Nonaka K, Sakai H.
    • Organizer
      88th IADR General Session
    • Place of Presentation
      Barcelona, Spain
    • Related Report
      2010 Final Research Report
  • [Presentation] アラジール症候群の患児に対する歯科治療の2例2010

    • Author(s)
      山座治義, 中村由紀, 増田啓次, 山口登, 野中和明
    • Organizer
      第48回日本小児歯科学会大会
    • Place of Presentation
      名古屋
    • Related Report
      2010 Final Research Report
  • [Presentation] 歯冠周囲に歯原性線維腫を認めた埋伏上顎中切歯を牽引誘導した1例2010

    • Author(s)
      中村由紀, 増田啓次, 山口登, 山座治義, 野中和明
    • Organizer
      第48回日本小児歯科学会大会
    • Place of Presentation
      名古屋
    • Related Report
      2010 Final Research Report
  • [Presentation] 生体肝移植を予定された患児に重症の齲蝕を認めたため術前に多数歯を抜去した1例2010

    • Author(s)
      増田啓次, 山口登, 中村由紀, 山座治義, 野中和明
    • Organizer
      第48回日本小児歯科学会大会
    • Place of Presentation
      名古屋
    • Related Report
      2010 Final Research Report
  • [Presentation] FoxO1転写因子はカロリー制限のストレス応答,抗腫瘍効果に関与する2010

    • Author(s)
      山座治義, 小松利光, 森亮一, 林洋子, 千葉卓哉, 古山達雄, 下川功
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Presentation] Mouse mandible contains distinctive mesenchymal stem cells2009

    • Author(s)
      Takayoshi Yamaza
    • Organizer
      32nd Annual Meeting and Scientific Symposium
    • Place of Presentation
      ホノルル(米国ハワイ州)
    • Year and Date
      2009-10-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] TISSUE-SPECIFIC VARIATION OF INSULIN SIGNAL IN CALORIC RESTRICTION2009

    • Author(s)
      Haruyoshi Yamaza
    • Organizer
      he American Aging Association 38th Annual Meeting
    • Place of Presentation
      スコッツデール(米国アリゾナ州)
    • Year and Date
      2009-06-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] カロリー制限におけるFoxO1転写因子の役割2009

    • Author(s)
      山座治義
    • Organizer
      第98回日本病理学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-05-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] 開口障害を伴うガードナー症候群の一例2009

    • Author(s)
      山座治義, 増田啓次, 中村由紀, 平野克枝, 山口登, 祐田京子, 野中和明
    • Organizer
      第27回日本小児歯科学会九州地方会
    • Place of Presentation
      北九州
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] ウイリアムズ症候群患児に見られた歯科的特徴2009

    • Author(s)
      山口登, 増田啓次, 山座治義, 中村由紀, 祐田京子, 野中和明
    • Organizer
      第27回日本小児歯科学会九州地方会
    • Place of Presentation
      北九州
    • Related Report
      2010 Final Research Report
  • [Presentation] 当小児歯科外来での脳性麻痺患者の9年間にわたる口腔管理2009

    • Author(s)
      立野麗子, 山口登, 増田啓次, 中村由紀, 山座治義, 馬場史子, 野中和明
    • Organizer
      第26回日本障害者歯科学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2010 Final Research Report
  • [Presentation] Mouse mandible contains distinctive mesenchymal stem cells.2009

    • Author(s)
      Yamaza T, Ren G, Akiyama K, Yamaza H, Nonaka K, Shi Y, Shi S.
    • Organizer
      32nd Annual Meeting and Scientific Symposium
    • Place of Presentation
      Honolulu, USA
    • Related Report
      2010 Final Research Report
  • [Presentation] マウス顎骨由来間葉系幹細胞の単離と特性解析2009

    • Author(s)
      山座孝義, 山座治義, 野中和明, 城戸瑞穂
    • Organizer
      第51回歯科基礎医学会総会
    • Place of Presentation
      新潟
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] Diets modulate frequencies of subsets of progenitor's stem cells in mouse bone marrow.2009

    • Author(s)
      Trindade LS, Nagata K, Yamaza H, Chiba T, Shimokawa I.
    • Organizer
      第32回日本基礎老化学会
    • Place of Presentation
      横浜
    • Related Report
      2010 Final Research Report
  • [Presentation] ROLE OF HYOTHALAMIC NEUROPEPTIDE Y IN THE BENEFICIAL EFFECTS OF CALORIE RESTRICTION.2009

    • Author(s)
      Chiba T, Yamaza H, Shimokawa I.
    • Organizer
      XIXth IAGG World Congress of Gerontology and Geriatrics
    • Place of Presentation
      Paris, France
    • Related Report
      2010 Final Research Report
  • [Presentation] A POTENTIAL ROLE FOR FOXO1 IN THE EFFECT OF CALORIE RESTRICTION.2009

    • Author(s)
      Isao S, Yamaza H, Komatsu T, Chiba T, Hayashi H, Furuyama T, Honda I, Shimokawa I.
    • Organizer
      XIXth IAGG World Congress of Gerontology and Geriatrics
    • Place of Presentation
      Paris, France
    • Related Report
      2010 Final Research Report
  • [Presentation] カロリー制限による代謝の変化におけるneuropeptideYの重要性2009

    • Author(s)
      千葉卓哉, 小松利光, 林洋子, 山座治義, 樋上賀一, 下川功
    • Organizer
      第32回日本基礎老化学会
    • Place of Presentation
      横浜
    • Related Report
      2010 Final Research Report
  • [Presentation] 脂肪特異的ノックアウトマウス脂肪組織における長期カロリー制限にともなう遺伝子発現プロフィール2009

    • Author(s)
      岡崎達哉, 沖田直之, 山座治義, 千葉卓哉, 下川功, 樋上賀一
    • Organizer
      第32回日本基礎老化学会
    • Place of Presentation
      横浜
    • Related Report
      2010 Final Research Report
  • [Presentation] カロリー制限時の白色脂肪組織におけるSrebp1支配遺伝子発現変動の網羅的解析2009

    • Author(s)
      仲條良和, 沖田直之, 伊藤麻希子, 鈴木智典, 宮崎智, 山座治義, 千葉卓哉, 下川功, 樋上賀一
    • Organizer
      第32回日本基礎老化学会
    • Place of Presentation
      横浜
    • Related Report
      2010 Final Research Report
  • [Presentation] TISSUE-SPECIFIC VARIATION OF INSULIN SIGNAL IN CALORIC RESTRICTION.2009

    • Author(s)
      Yamaza H, Park S, Chiba T, Nonaka K, Shimokawa I.
    • Organizer
      The American Aging Association 38th Annual Meeting
    • Place of Presentation
      Scottsdale, USA
    • Related Report
      2010 Final Research Report
  • [Presentation] カロリー制限におけるFoxO1転写因子の役割2009

    • Author(s)
      山座治義, 小松利光, 千葉卓哉, 林洋子, 下川功
    • Organizer
      第98回日本病理学会総会
    • Place of Presentation
      京都
    • Related Report
      2010 Final Research Report
  • [Presentation] Calorie restriction-specific adipose tissue metabolic profile : different from the effect of growth hormone suppression2008

    • Author(s)
      Seongjoon Park
    • Organizer
      The 9th International Congress on Cell Biology
    • Place of Presentation
      ソウル(韓国)
    • Year and Date
      2008-10-07
    • Related Report
      2008 Annual Research Report
  • [Presentation] Calorie restriction disrupts hepatic insulin signal transduction in mice2008

    • Author(s)
      Haruyoshi Yamaza
    • Organizer
      The Japan-Korea Joint Seminar(AACL2008)-To ward the establishment of Asian Aging Research and Education Center
    • Place of Presentation
      ハウステンボス(長崎県佐世保)
    • Year and Date
      2008-09-05
    • Related Report
      2008 Annual Research Report
  • [Presentation] Calorie restriction-specific adipose tissue metabolic profile : difference from the, effect of growth hormone suppression2008

    • Author(s)
      Seongjoon Park
    • Organizer
      The Japan-Korea Joint Seminar(AACL2008)-To ward the establishment of Asian Aging Research and Education Center
    • Place of Presentation
      ハウステンボス(長崎県佐世保)
    • Year and Date
      2008-09-05
    • Related Report
      2008 Annual Research Report
  • [Presentation] A role for FoxO1 in the effect of calorie restriction on oxidative stress and lifespan2008

    • Author(s)
      Calorine Kijogi
    • Organizer
      The Japan-Korea Joint Seminar(AACL2008)-To ward the establishment of Asian. Aging Research and Education Center
    • Place of Presentation
      ハウステンボス(長崎県佐世保)
    • Year and Date
      2008-09-05
    • Related Report
      2008 Annual Research Report
  • [Presentation] Caloric restriction upregulates the Akt-Glut pathway in the white adipose tissue possibly through moderate suppression of growth hormone2008

    • Author(s)
      Seongjoon Park
    • Organizer
      第31回日本基礎老化学会
    • Place of Presentation
      松本
    • Year and Date
      2008-06-13
    • Related Report
      2008 Annual Research Report
  • [Presentation] Does moderate suppression of growth hormone axis mimic the effect of caloric restriction on the insulin signaling in the white adipose tissue?2008

    • Author(s)
      Seongjoon Park
    • Organizer
      American Aging Association-37th Annual Meeting
    • Place of Presentation
      ボルダー(米国コロラド州)
    • Year and Date
      2008-06-01
    • Related Report
      2008 Annual Research Report
  • [Presentation] Calorie restriction disrupts hepatic insulin signal transduction in mice2008

    • Author(s)
      Haruyoshi Yamaza
    • Organizer
      2008 Spring Conference of the Korean Society for Gerontology and AVDRC symposium
    • Place of Presentation
      デグ(韓国)
    • Year and Date
      2008-05-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] カロリー制限に対する代謝の応答はインスリンおよびレプチン抵抗性を示す肥満ラットにおいても起こる2008

    • Author(s)
      千葉卓哉, 小松利光, 中山正彦, 足立利幸, 林洋子, 山座治義, 樋上賀一, 下川功
    • Organizer
      第31回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Related Report
      2010 Final Research Report
  • [Presentation] Longevity genes.2008

    • Author(s)
      Shimokawa I, Chiba T, Yamaza H, Komatsu T.
    • Organizer
      The 10th International Symposium on Vascular Aging : molecular exploration and micro-inflammatory implications.
    • Place of Presentation
      Busan, Korea
    • Related Report
      2010 Final Research Report
  • [Presentation] Calorie restriction-specific adipose tissue metabolic profile : different from the effect of growth hormone suppression.2008

    • Author(s)
      Park S, Komatsu T, Hayashi H, Trindade LS, Yamaza H, Chiba T, Shimokawa I.
    • Organizer
      The 9th International Congress on Cell Biology
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2010 Final Research Report
  • [Presentation] 老化促進モデルマウスSAMP8の学習記憶能における食餌成分およびカロリー制限の影響2008

    • Author(s)
      千葉卓哉, 小松利光, 山座治義, 山下樹三裕, 島田厚良, 樋上賀一, de Cabo R., Ingram D.K., 下川功
    • Organizer
      第51回日本神経化学会
    • Place of Presentation
      富山
    • Related Report
      2010 Final Research Report
  • [Presentation] Calorie restriction increases TORC2-dependent CREB activity for induction of gluconeogenetic gene expression by down-regulation of AMPK.2008

    • Author(s)
      Trindade LS, Park S, Komatsu T, Yamaza H, Chiba T, Higami Y, Shimokawa I.
    • Organizer
      The 9th International Congress on Cell Biology
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2010 Final Research Report
  • [Presentation] Identification and characterization of food deprivation-activated genes and insulin receptor substrate interacting protein.2008

    • Author(s)
      Chiba T, Yamaza H, Shimokawa I.
    • Organizer
      The Japan-Korea Joint Seminar (AACL2008)-Toward the establishment of Asian Aging Research and Education Center
    • Place of Presentation
      Huis Ten Bosch, Japan
    • Related Report
      2010 Final Research Report
  • [Presentation] Calorie restriction disrupts hepatic insulin signal transduction in mice.2008

    • Author(s)
      Yamaza H, Park S, Chiba T, Shimokawa I.
    • Organizer
      The Japan-Korea Joint Seminar (AACL2008)-Toward the establishment of Asian Aging Research and Education Center
    • Place of Presentation
      Huis Ten Bosch, Japan
    • Related Report
      2010 Final Research Report
  • [Presentation] Calorie restriction-specific adipose tissue metabolic profile : difference from the effect of growth hormone suppression.2008

    • Author(s)
      Park S, Komatsu T, Hayashi H, Trindade LS, Yamaza H, Chiba T, Shimokawa I.
    • Organizer
      The Japan-Korea Joint Seminar (AACL2008)-Toward the establishment of Asian Aging Research and Education Center
    • Place of Presentation
      Huis Ten Bosch, Japan
    • Related Report
      2010 Final Research Report
  • [Presentation] Does a high fat diet inhibit mobilization of bone marrow (BM) progenitor stem cells2008

    • Author(s)
      Trindade LS, Nagai K, Park S, Chiba T, Yamaza H, Shimokawa I.
    • Organizer
      The Japan-Korea Joint Seminar (AACL2008)-Toward the establishment of Asian Aging Research and Education Center
    • Place of Presentation
      Huis Ten Bosch, Japan
    • Related Report
      2010 Final Research Report
  • [Presentation] A role for FoxO1 in the effect of calorie restriction on oxidative stress and lifespan.2008

    • Author(s)
      Kijogi C, Komatsu T, Furuyama T, Chiba T, Yamaza H, Shimokawa I.
    • Organizer
      The Japan-Korea Joint Seminar (AACL2008)-Toward the establishment of Asian Aging Research and Education Center
    • Place of Presentation
      Huis Ten Bosch, Japan
    • Related Report
      2010 Final Research Report
  • [Presentation] Calorie restriction increases TORC2-dependent CREB activity for induction of gluconeogenetic gene expression by down-regulation of AMPK.2008

    • Author(s)
      Trindade LS, Komatsu T, Yamaza H, Chiba T, Higami Y, Shimokawa I.
    • Organizer
      第31回日本基礎老化学会
    • Place of Presentation
      松本
    • Related Report
      2010 Final Research Report
  • [Presentation] Caloric restriction upregulates the Akt-Glut pathway in the white adipose tissue possibly through moderate suppression of growth hormone.2008

    • Author(s)
      Park S, Komatsu T, Hayashi H, Yamaza H, Chiba T, Higami Y, Shimokawa I.
    • Organizer
      第31回日本基礎老化学会
    • Place of Presentation
      松本
    • Related Report
      2010 Final Research Report
  • [Presentation] GH/IGF-I系の抑制は白色脂肪組織におけるresistin発現を減少させ血糖値を低下させる2008

    • Author(s)
      千葉卓哉, 山座治義, 小松利光, 中山正彦, 藤田智, 林洋子, 樋上賀一, 下川功
    • Organizer
      第31回日本基礎老化学会
    • Place of Presentation
      松本
    • Related Report
      2010 Final Research Report
  • [Presentation] FoxOファミリーの細胞内局在におけるカロリー制限の影響2008

    • Author(s)
      山座治義, 朴盛浚, 千葉卓哉, 小松利光, 下川功
    • Organizer
      第31回日本基礎老化学会
    • Place of Presentation
      松本
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] Does moderate suppression of growth hormone axis mimic the effect of caloric restriction on the insulin signaling in the white adipose tissue2008

    • Author(s)
      Park S, Komatsu T, Hayashi H, Yamaza H, Chiba T, Higami Y, Shimokawa I.
    • Organizer
      The American Aging Association 37th Annual Meeting
    • Place of Presentation
      Bouldar, USA
    • Related Report
      2010 Final Research Report
  • [Presentation] Role of FoxO1 in Caloric Restriction.2008

    • Author(s)
      Yamaza H, Park S, Chiba T, Shimokawa I.
    • Organizer
      The 8th Korea-Japan Gerontologist Joint Meeting, 2008 Spring Conference of the Korean Society for Gerontology and AVDRC symposium
    • Place of Presentation
      Daegu, Korea
    • Related Report
      2010 Final Research Report
  • [Presentation] 白色脂肪組織におけるカロリー制限によるアセチル化,脱アセチル化酵素発現の変化とその標的タンパク2008

    • Author(s)
      樋上賀一, 千葉卓哉, 山座治義, 戸田年総, 下川功
    • Organizer
      第97回日本病理学会総会
    • Place of Presentation
      金沢
    • Related Report
      2010 Final Research Report
  • [Book] 小児歯科学第4版(高木裕三, 他 編)2011

    • Author(s)
      山座治義, 野中和明
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2010 Final Research Report
  • [Book] 小児歯科学2011

    • Author(s)
      山座治義, 他
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2010 Annual Research Report
  • [Book] 抗加齢眼科学(眼科プラクティス)(坪田一男 編) 222008

    • Author(s)
      山座治義, 下川功
    • Publisher
      文光堂
    • Related Report
      2010 Final Research Report
  • [Book] Handbook on Immunosenescence(Fulop T et al., eds.)(A transgenic dwarf rat strain as a tool for the study of immunosenescence in aging rats and the effect of calorie restriction)2008

    • Author(s)
      Shimokawa I, Utsuyama M, Komatsu T, Yamaza H, Chiba T.
    • Publisher
      Springer Science+ Business
    • Related Report
      2010 Final Research Report
  • [Book] 小児科学第10版(五十嵐隆編)

    • Author(s)
      山座治義, 野中和明
    • Publisher
      文光堂(印刷中)
    • Related Report
      2010 Final Research Report
  • [Book] サイエンスに基づいたアンチエイジング(坪田一男, 門脇孝,編)

    • Author(s)
      山座治義, 千葉卓哉, 下川功
    • Publisher
      メディカルレビュー社(印刷中)
    • Related Report
      2010 Final Research Report
  • [Book] 老化・老年病研究のための動物実験ガイドブック(基礎老化学会 編)2008

    • Author(s)
      千葉卓哉, 山座治義, 下川功
    • Publisher
      アドスリー
    • Related Report
      2010 Final Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi