Study on endoplasmic reticulum stress response to novel blood glucose regulatory system and glucotoxicity in caloric restriction
| Project/Area Number |
20790260
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Nagasaki University |
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Principal Investigator |
YAMAZA Haruyoshi Nagasaki University, 大学病院, 講師 (30336151)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | カロリー制限 / 老化 / インスリンシグナル / 糖代謝 |
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| Research Abstract |
To elucidate the effect of lifespan extension by caloric restriction (CR), endoplasmic reticulum (ER) stress response and FoxO1 were focused. In ES-TRAP mice, the response of ER stress trended to be reduced by CR. In FoxO1 knockout (ko) mice, the upregulation of gene expression related with cell cycle arrest and DNA repair by CR was inhibited under the oxidative stress condition. In addition, the antineoplastic effect of CR was abrogated in the ko-CR mice. These resulted suggested that FoxO1 is involved in the response for oxidative stress and antineoplastic effect by CR.
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Report
(4 results)
Research Products
(92 results)
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[Journal Article] Protogenin, a new member of the immunoglobulin superfamily, is implicated in the development of the mouse lower first molar.2010
Author(s)
Takahashi KF, Kiyoshima T, Kobayashi I, Xie M, Yamaza H, Fujiwara H, Ookuma Y, Nagata K, Wada H, Sakai T, Terada Y, Sakai H.
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Journal Title
BMC Dev Biol. 10
Pages: 115-115
Related Report
Peer Reviewed
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[Journal Article] SIRT1 Regulates Thyroid-Stimulating Hormone Release by Enhancing PIP5Kgamma Activity through Deacetylation of Specific Lysine Residues in Mammals.2010
Author(s)
Akieda-Asai S, Zaima N, Ikegami K, Kahyo T, Yao I, Hatanaka T, Iemura S, Sugiyama R, Yokozeki T, Eishi Y, Koike M, Ikeda K, Chiba T, Yamaza H, Shimokawa I, Song SY, Matsuno A, Mizutani A, Sawabe M, Chao MV, Tanaka M, Kanaho Y, Natsume T, Sugimura H, Date Y, McBurney MW, Guarente L, Setou M.
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Journal Title
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Peer Reviewed
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[Journal Article] FoxO1 is involved in the antineoplastic effect of calorie restriction.2010
Author(s)
Yamaza H, Komatsu T, Wakita S, Kijogi C, Park S, Hayashi H, Chiba T, Mori R, Furuyama T, Mori N, Shimokawa I.
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Journal Title
Aging Cell 9(3)
Pages: 372-782
NAID
Related Report
Peer Reviewed
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[Journal Article] entification and characterization of an insulin receptor substrate 4-interacting protein in rat brain : Implications for longevity.2009
Author(s)
Chiba T, Inoue D, Mizuno A, Komatsu T, Fujita S, Kubota H, Luisa Tagliaro M, Park S, Trindade LS, Hayashida T, Hayashi H, Yamaza H, Higami Y, Shimokawa I.
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Journal Title
Neurobiol Aging 30(3)
Pages: 474-482
Related Report
Peer Reviewed
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[Journal Article] Manipulation of caloric content but not diet composition, attenuates the deficit in learning and memory of senescence-accelerated mouse strain P8.2008
Author(s)
Komatsu T, Chiba T, Yamaza H, Yamashita K, Shimada A, Hoshiyama Y, Henmi T, Ohtani H, Higami Y, de Cabo R, Ingram DK, Shimokawa I.
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Journal Title
Exp.Gerontol. 43(4)
Pages: 339-346
Related Report
Peer Reviewed
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[Presentation] 腹7分目の健康科学2010
Author(s)
山座治義
Organizer
第28回日本小児歯科学会九州地方会大会
Place of Presentation
福岡県歯科医師会館(福岡市)
Year and Date
2010-10-03
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[Presentation] Longevity genes.2008
Author(s)
Shimokawa I, Chiba T, Yamaza H, Komatsu T.
Organizer
The 10th International Symposium on Vascular Aging : molecular exploration and micro-inflammatory implications.
Place of Presentation
Busan, Korea
Related Report
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[Presentation] Role of FoxO1 in Caloric Restriction.2008
Author(s)
Yamaza H, Park S, Chiba T, Shimokawa I.
Organizer
The 8th Korea-Japan Gerontologist Joint Meeting, 2008 Spring Conference of the Korean Society for Gerontology and AVDRC symposium
Place of Presentation
Daegu, Korea
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