Characterization of annexin IV complex for new therapeutic development to ovarian clear cell adenocarcinoma

• Project/Area Number: 20790262
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Pathological medical chemistry
• Research Institution: Yokohama City University
• Principal Investigator: ARAKAWA Noriaki Yokohama City University, 生命ナノシステム科学研究科, 助教 (60398394)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2008: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
• Keywords: 分子腫瘍学 / 卵巣癌 / 明細胞腺癌 / アネキシンIV / タンパク質複合体 / プロテオミクス

Research Abstract

The protein annexin IV (ANX4) is elevated specifically and characteristically in ovarian clear cell adenocarcinoma (CCA), a highly malignant histological subtype of epithelial ovarian cancer. To clarify the functional and physiological role of the ANX4 protein in CCA, we conducted proteomic analyses to identify its binding partners. This analyses revealed that ANX4 formed a protein complex with several nucleic acid binding proteins.

Research Products

• [Presentation] 卵巣明細胞腺癌におけるアネキシンIV複合体の構成因子の同定 (2009)
  • Author(s): 荒川憲昭, 田矢史織, 川崎博史, 宮城悦子, 平原史樹, 平野久
  • Organizer: 日本生化学会
  • Place of Presentation: 神戸
  • Year and Date: 2009-10-22
• [Presentation] 卵巣明細胞腺癌におけるアネキシンIV複合体の構成因子の同定 (2009)
  • Author(s): 荒川憲昭、田矢史織、川崎博史, 宮城悦子, 平原史樹, 平野久
  • Organizer: 日本生化学会
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2009-10-22
• [Presentation] 卵巣明細胞腺癌におけるアネキシンIV複合体の機能解析 (2009)
  • Author(s): 荒川憲昭, 田矢史織, 川崎博史, 宮城悦子, 平原史樹, 平野久
  • Organizer: 日本ヒトプロテオーム機構
  • Place of Presentation: 東京
  • Year and Date: 2009-07-28
• [Presentation] 卵巣明細胞腺癌におけるアネキシンIV複合体の機能解析 (2009)
  • Author(s): 荒川憲昭、田矢史織、川崎博史, 宮城悦子, 平原史樹, 平野久
  • Organizer: 日本ヒトプロテオーム機構
  • Place of Presentation: 北里大学白金キャンパス
  • Year and Date: 2009-07-28
• [Presentation] 新規p53ターゲットANX4は卵巣明細胞腺癌のp53活性を低下させる (2009)
  • Author(s): 増石有佑、荒川憲昭、川崎博史, 宮城悦子, 平原史樹, 平野久
  • Organizer: 日本ヒトプロテオーム機構
  • Place of Presentation: 東京
  • Year and Date: 2009-07-27
• [Presentation] 新規p53ターゲットANX4は卵巣明細胞腺癌のp53活性を低下させる (2009)
  • Author(s): 増石有佑、荒川憲昭、川崎博史, 宮城悦子, 平原史樹, 平野久
  • Organizer: 日本ヒトプロテオーム機構
  • Place of Presentation: 北里大学白金キャンパス
  • Year and Date: 2009-07-27
• [Presentation] 卵巣明細胞腺癌におけるリン脂質結合タンパク質アネキシンIVの性状解析 (2008)
  • Author(s): 田矢史織, 荒川憲昭, 川崎博史, 宮城悦子, 平原史樹, 平野久
  • Organizer: BMB2008
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-11
• [Presentation] 卵巣明細胞腺癌におけるリン脂質結合タンパク質アネキシンIVの性状解析 (2008)
  • Author(s): 田矢史織, 荒川憲昭, 川崎博史, 宮城悦子, 平原史樹, 平野久
  • Organizer: MB2008
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2008-12-11
• [Presentation] New potential therapeutic targets for ovarian clear cell carcinoma (2008)
  • Author(s): Noriaki Arakawa, Yusuke Masuishi, Yuko Yamanaka, Hiroshi Kawasaki, Etsuko Miyagi, Fumiki Hirahara, Hisashi Hirano
  • Organizer: Meeting of methods in protein structure analysis
  • Place of Presentation: 札幌
  • Year and Date: 2008-08-27
• [Presentation] New potential therapeutic targets for ovarian clear cell carcinoma Meeting of methods in protein structure analysis (2008)
  • Author(s): Noriaki Arakawa, Yusuke Masuishi, Yuko Yamanaka, Hiroshi Kawasaki, Etsuko Miyagi, Fumiki Hirahara, Hisashi Hirano
  • Organizer: MPSA2008
  • Place of Presentation: 札幌
  • Year and Date: 2008-08-27
• [Presentation] Proteomic analysis for identification of therapeutic targets of ovarian clear cell carcinoma (2008)
  • Author(s): Noriaki Arakawa, Yusuke Masuishi, Yuko Yamanaka, Hiroshi Kawasaki, Etsuko Miyagi, Fumiki Hirahara, Hisashi Hirano
  • Organizer: 4th Asian Oceania Human Proteome Organisations
  • Place of Presentation: ケアンズ
  • Year and Date: 2008-06-23
• [Presentation] Proteomic analysis for identification of therapeutic targets of ovarian clear cell carcinoma (2008)
  • Author(s): Noriaki Arakawa, Yusuke Masuishi, Yuko Yamanaka, Hiroshi Kawasaki, Etsuko Miyagi, Fumiki Hirahara, Hisashi Hirano
  • Organizer: 4th Asian Oceania Human Proteome Organisations
  • Place of Presentation: ケアンズ・オーストラリア
  • Year and Date: 2008-06-23
• [Patent(Industrial Property Rights)] 卵巣明細胞腺癌に特異的に発現しているタンパク質とその応用 (2010)
  • Inventor(s): 荒川憲昭、増石有佑、山中結子、平野久、川崎博史、平原史樹、宮城悦子
  • Industrial Property Rights Holder: 公立大学法人横浜市立大学
  • Industrial Property Number: 2010-035737
  • Filing Date: 2010-02-22