Characterization of annexin IV complex for new therapeutic development to ovarian clear cell adenocarcinoma
| Project/Area Number |
20790262
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Yokohama City University |
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Principal Investigator |
ARAKAWA Noriaki Yokohama City University, 生命ナノシステム科学研究科, 助教 (60398394)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
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| Keywords | 分子腫瘍学 / 卵巣癌 / 明細胞腺癌 / アネキシンIV / タンパク質複合体 / プロテオミクス |
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| Research Abstract |
The protein annexin IV (ANX4) is elevated specifically and characteristically in ovarian clear cell adenocarcinoma (CCA), a highly malignant histological subtype of epithelial ovarian cancer. To clarify the functional and physiological role of the ANX4 protein in CCA, we conducted proteomic analyses to identify its binding partners. This analyses revealed that ANX4 formed a protein complex with several nucleic acid binding proteins.
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Report
(3 results)
Research Products
(13 results)
