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LKB-1, K-ras, and EGFR gene mutation involvement in the multistep tumorigenesis of primary lung adenocarcinomas

Research Project

Project/Area Number 20790274
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Human pathology
Research InstitutionChiba University

Principal Investigator

OIDE Takashi  Chiba University, 大学院・医学研究院, 助教 (00422246)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords病理学 / 肺癌 / 腺癌 / 発癌
Research Abstract

In the present study, we detected a case of primary pulmonary adenocarcinoma with an immunohistochemically proven ALK abnormality. The tumor showed an endobronchial polypoid growth pattern with peripheral pulmonary tissue invasion. Recently, lung cancers having ALK gene abnormalities have attracted growing attention because of therapeutic aspects, i.e., ALK inhibitor therapies. The present case is the first case of ALK-immunopositive lung cancer suggesting central bronchial surface epithelial origin.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (5 results)

All 2010 2009 2008

All Presentation (5 results)

  • [Presentation] 印環細胞癌への分化を伴ったALK陽性endobronchial polypoid adenocarcinomaの1例.2010

    • Author(s)
      大出貴士, 岸本充, 廣島健三, 溝渕輝明, 鈴木実, 吉野一郎, 中谷行雄
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      東京
    • Year and Date
      2010-04-27
    • Related Report
      2009 Final Research Report
  • [Presentation] A case of primary intrapulmonary meningioma.2009

    • Author(s)
      Takashi Oide, Michiyo Kambe, Kenzo Hiroshima, Hajime Tamura, Yasumitsu Moriya, Hidehisa Hoshino, Kiyoshi Shibuya, Ichiro Yoshino, Mari Mino-Kenudson, Eugene J. Mark, Yukio Nakatani.
    • Organizer
      第55回日本病理学会秋期特別総会
    • Place of Presentation
      東京
    • Year and Date
      2009-11-19
    • Related Report
      2009 Final Research Report
  • [Presentation] A case of primary intrapulmonary meningioma2009

    • Author(s)
      大出貴士
    • Organizer
      第55回日本病理学会秋期特別総会
    • Place of Presentation
      東京都千代田区
    • Year and Date
      2009-11-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] 左気管支下幹原発のglomus tumorの1例2008

    • Author(s)
      大出貴士, 廣島健三, 米盛葉子, 谷澤徹, 安福和弘, 渋谷潔, 吉野一郎, 中谷行雄
    • Organizer
      第97回日本病理学会総会
    • Place of Presentation
      金沢
    • Year and Date
      2008-05-17
    • Related Report
      2009 Final Research Report
  • [Presentation] 左気管支下幹原発のglomus tumorの1例2008

    • Author(s)
      大出貴士
    • Organizer
      第97回日本病理学会総会
    • Place of Presentation
      石川県金沢市
    • Year and Date
      2008-05-17
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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