Functional analysis of the proteins with TPR motifs which are associated with the cerebral nerve function

Research Project

Project/Area Number	20790292
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Human pathology
Research Institution	Keio University
Principal Investigator	IZUMIYAMA Tomohiro Keio University, 医学部, 助教 (80424183)
Project Period (FY)	2008 – 2009
Project Status	Completed (Fiscal Year 2009)
Budget Amount *help	¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000) Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords	脳 / 神経 / TPRモチーフ / 細胞周期M期 / 細胞質分裂 / 中央体 / 収縮環 / siRNA / 二核細胞 / タンパク質問相互作用 / 細胞分裂 / 中心体 / 紡錘体 / Midzone / Midbody
Research Abstract	We studied about TPRBK protein which were highly expressed in human and mouse brain tissue and embryonic tissue of medaka. We carried out coimmunoprecipitation analysis to identify proteins which interact with TPRBK protein and immunofluorescence assay by using anti-TPRBK antibody. These studies revealed that : First, TPRBK interacts with X and Y which are associated with the function of cell division. Second, the localization of TPRBK is changed from centrosomes to the midbody during mitosis and cytokinesis. Third, TPRBK associates with the system of cytokinesis.

Report

(3 results)