Renewal of microglia by intra-bone marrow bone marrow transplantation as a preventive and therapeutic strategy for neurodegeneration
| Project/Area Number |
20790319
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Experimental pathology
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| Research Institution | Institute for Developmental Research, Aichi Human Service Center |
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Principal Investigator |
ISHII Sanae Institute for Developmental Research, Aichi Human Service Center, 発達障害研究所・病理学部, 研究員 (40435863)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 骨髄内骨髄移植 / ミクログリア / 神経変性疾患 / 老化促進モデルマウス |
|---|
| Research Abstract |
骨髄の単球系に由来するミクログリアは神経保護機能を有することから、その異常は神経変性を誘導するといわれている。我々は神経変性病態において異常なミクログリアを正常なそれで置き換えることによって、変性病態を改善できないかと考えた。そこで、骨髄内骨髄移植を行い、まずミクログリアが置換される時間経過などの基礎的知見を得た後、そうした処置が神経変性を改善する可能性を検討した。その結果ドナー由来細胞は時間依存的に脳の限局された領域に入りミクログリアに分化したが、今回の条件では神経変性の治療にまでは至らなかった。
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Report
(3 results)
Research Products
(39 results)
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[Journal Article] A. (2010) Morpholo gical impairments in microglia precede age-related neuronal degeneration in se nescence-accelerated mice2010
Author(s)
Hasegawa-Ishii, S., Takei, S., Chiba, Y., Furukawa, A., Umegaki, H., Iguchi, A., Kawamura, N., Yoshikawa, K., Hosok awa, M., Shimada
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Journal Title
Neuropatholo gy (In press)
Pages: 22-26
Related Report
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[Journal Article] Morphological impairments in microglia precede age-related neuronal degeneration in senescence-accelerated mice.2010
Author(s)
Haseqawa-lshii, S., Takei, S., Chiba, Y., Furukawa, A., Umegaki, H., Iguchi, A., Kawamura, N., Yoshikawa, K., Hosokawa, M., Shimada, A.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] The Senescence-accelerated Mouse (SAM): a higher oxidative stress and agedependent degenerative diseases model2009
Author(s)
Chiba, Y., Shimada, A., Kumagai, N., Yoshikawa, K., Ishii, S., Furukawa, A., Takei, S., Sakura M., Kawamura, N., Hosokawa, M.
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Journal Title
Neurochem 34
Pages: 679-87
Related Report
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[Journal Article] The Senescence-accelerated Mouse (SAM) : a higher oxidative stress and age-dependent degenerative diseases model.2009
Author(s)
Chiba, Y., Shimada, A., Kumagai, N., Yoshikawa, K., Ishii, S., Furukawa, A., Takei, S., Sakura M., Kawamura, N., Hosokawa, M.
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Journal Title
Neurochem. Res. 34
Pages: 679-687
Related Report
Peer Reviewed
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[Journal Article] Neuronal toxicity of expanded polyglutamine depends on intracellular distribution in addition to the expression level2008
Author(s)
Satoh, M., Shimada, A., Kawamura, N., Chiba, Y., Yoshikawa, K., Ishii, S., Furukawa, A., Kumagai, N., Hosokawa, M.
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Journal Title
Neuropathology 28
Pages: 485-496
NAID
Related Report
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[Journal Article] Reduced expression of MAb6B4 epitopes on chondroitin sulfate proteoglycan aggrecan in perineuronal nets from the cerebral cortices of SAMP10 mice2008
Author(s)
Saitoh, Y., Matsui, F., Chiba, Y., Kawamura, N., Keino, H., Satoh, M., Kumagai, N., Ishii, S., Yoshikawa, K., Shimada, A., Maeda, N., Oohira, A., Hosokawa, M.
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Journal Title
A model for age-dependent neurodegeneration. J. Neurosci. 86
Pages: 1316-1323
Related Report
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[Journal Article] Neuronal toxicity of expanded polyglutamine depends on intracellular distribution in addition to the expression level2008
Author(s)
Satoh, M., Shimada, A., Kawamura, N., Chiba, Y., Yoshikawa K., Ishii, S., Furukawa, A., Kumagai, N., and Hosokawa, M.
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Journal Title
Neuropathology 28
Pages: 485-496
NAID
Related Report
Peer Reviewed
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[Journal Article] Reduced expression of MAb6B4 epitopes on chondroitin sulfate proteoglycan aggrecan in perineuronal nets from the cerebral cortices of SAMP10 mice : A model for age-dependent neurodegeneration.2008
Author(s)
Saitoh, Y., Matsui, F., Chiba, Y., Kawamura, N., Keino, H., Satoh, M., Kumagai, N., Ishii, S., Yoshikawa, K., Shimada, A., Maeda, N., Oohira, A., and Hosokawa, M.
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Journal Title
J. Neurosci. Res. 86
Pages: 1316-1323
Related Report
Peer Reviewed
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