Identification of a host factor recognizing Aspergillus fumigatus
| Project/Area Number |
20790329
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Chiba University |
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Principal Investigator |
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| Project Period (FY) |
2008 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | 真菌 / 感染症 / アスペルギルス / バイオフィルム / 血清タンパク質 / フェツイン / 血清たんぱく質 / 真菌結合宿主因子 |
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| Research Abstract |
Aspergillosis is one of the most important mycoses in the world. In this study, we explored host factors recognizing conidia and/or hyphae of Aspergillus fumigatus. We identified a host factor, fetuin A, as a binding protein to A. fumigatus hyphae. Additionally, our data indicated that fetuin A induced the formation of biofilm of A. fumigatus. Therefore, we suggest that binding of fetuin A to A. fumigatus hyphae induces the formation of biofilm playing a pivotal role in the pathogenesis of the infection.
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Report
(6 results)
Research Products
(40 results)
