| Project/Area Number |
20790333
|
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Kyoto University |
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Principal Investigator |
HARA Hideki Kyoto University, 医学研究科, 助教 (30456892)
|
|---|
| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
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| Keywords | 感染免疫 / 細菌 / 病原因子 / マクロファージ / IL-18 / Listeria monocytogenes / listeriolysin 0 / caspase-1 |
|---|
| Research Abstract |
Caspase-1 plays an important role in the activation of host immune response through the secretion of pro-inflammatory cytokines including IL-1 and IL-18 in bacterial infection. Based on our results, we concluded that AIM2, which is known as a DNA sensor, is involved in caspase-1 activation induced by Listeria infection and the response is enhanced by listeriolysin O.
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