The study on mechanism of listeriolysin O-dependent IL-18 production induced by Listeria infection
| Project/Area Number |
20790333
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Kyoto University |
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Principal Investigator |
HARA Hideki Kyoto University, 医学研究科, 助教 (30456892)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 感染免疫 / 細菌 / 病原因子 / マクロファージ / IL-18 / Listeria monocytogenes / listeriolysin 0 / caspase-1 |
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| Research Abstract |
Caspase-1 plays an important role in the activation of host immune response through the secretion of pro-inflammatory cytokines including IL-1 and IL-18 in bacterial infection. Based on our results, we concluded that AIM2, which is known as a DNA sensor, is involved in caspase-1 activation induced by Listeria infection and the response is enhanced by listeriolysin O.
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Report
(3 results)
Research Products
(32 results)
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[Journal Article] Toll-like receptor 2- and MyD88-dependent phosphatidylinositol 3-kinase and Rac1 activation facilitates the phagocytosis of Listeria monocytogenes by murine macrophages.2010
Author(s)
Shen Y, Kawamura I, Nomura T, Tsuchiya K, Hara H, Dewamitta SR, Sakai S, Qu H, Daim S, Yamamoto T, Mitsuyama M
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Journal Title
Infect. Immun. 78
Pages: 2857-2867
NAID
Related Report
Peer Reviewed
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[Journal Article] Listeriolysin O-dependent bacterial entry into cytoplasm is required for calpain activation and IL-1alpha secretion in macrophages infected with Listeria monocytogenes.2010
Author(s)
Dewamitta SR, Nomura T, Kawamura I, Hara H, Tsuchiya K, Kurenuma T, Shen Y, Daim S, Yamamoto T, Qu H, Sakai S, Xu Y, Mitsuyama M
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Journal Title
Infect. Immun. 78
Pages: 1884-1894
Related Report
Peer Reviewed
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