Regulation of autoimmunity by B lymphocyte coreceptor CD72
Project/Area Number |
20790371
|
Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Immunology
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Research Institution | Tokyo Medical and Dental University |
Principal Investigator |
WATANABE Kozo Tokyo Medical and Dental University, 難治疾患研究所, 助教 (20376718)
|
Project Period (FY) |
2008 – 2009
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | 免疫寛容 / 自己免疫 / 免疫寛容・自己免疫 / CD72 / Cタイプ様レクチン / Bリンパ球 / 糖鎖リガンド |
Research Abstract |
In this study, I suggested that CD72 interacts with glycan by glycan array analysis and surface plasmon resonance analysis using purified recombinant CD72 protein. I also suggested that CD72 negatively regulates B cell proliferation by B cell antigen receptor ligation in the presence of CD72 glycan ligand by the experiments using purified B cells from CD72 defficient mice. These results suggest a new mechanism of negative regulation of a B cell immune response by the CD72 glycan ligand-CD72
|
Report
(3 results)
Research Products
(21 results)
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[Journal Article] CD22-Antagonists with nanomolar potency : The synergistic effect of hydrophobic groups at C-2 and C-9 of sialic acid scaffold2011
Author(s)
Hajjaj H.M. Abdu-Allah, Kozo Watanabe, Gladys C. Completo, Magesh Sadagopan, Koji Hayashizaki, Chiaki Takaku, Taichi Tamanaka, Hiromu Takematsu, Yasunori Kozutsumi, James C. Paulson, Takeshi Tsubata, Hiromune Ando, Hideharu Ishida, Makoto Kiso
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Journal Title
Bioorg.Med.Chem. 19
Pages: 1966-1971
Related Report
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[Journal Article] CD22-Antagonists with nanomolar potency : The synergistic effect of hydrophobic groups at C-2 and C-9 of sialic acid scaffold2011
Author(s)
Hajjaj H.M.Abdu-Allah, Kozo Watanabe, Gladys C.Completo, Magesh Sadagopan, Koji Hayashizaki, Chiaki Takaku, Taichi Tamanaka, Hiromu Takematsu, Yasunori Kozutsumi, James C.Paulson, Takeshi Tsubata, Hiromune Ando, Hideharu Ishida, Makoto Kiso
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Journal Title
Bioorg.Med.Chem.
Volume: 19
Pages: 1966-71
Related Report
Peer Reviewed
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[Journal Article] Potent Small Molecule Mouse CD22 Inhibitors: Exploring the Interaction of the Residue at C-2 of Sialic Acid Scaffold Bioorg.2009
Author(s)
Abdu-Allah, H.H.M., Watanabe, K., Hayashizaki, K., Takaku, C., Tamanaka, T., Takematsu, H., Kozutsumi, Y., Tsubata, T., Ishida, H., Kiso, M.
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Journal Title
Med.Chem.Lett. 19
Pages: 5573-5575
Related Report
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[Journal Article] Synthesis of biotinylated sialoside to probe CD22-ligand interactions2009
Author(s)
Abdu-Allah, H.H.M., Watanabe, K., Hayashizaki, K., Iwayama, Y., Takematsu, H., Kozutsumi, Y., Tsubata, T., Ishida, H., Kiso, M.
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Journal Title
Tetrahedron Lett. 50
Pages: 4488-4491
Related Report
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[Journal Article] Potent Small Molecule Mouse CD22 Inhibitors : Exploring the Interaction of the Residue at C-2 of Sialic Acid Scaffold2009
Author(s)
Abdu-Allah, H.H.M., Watanabe, K., Hayashizaki, K, Takaku, C., Tamanaka, T., Takematsu, H, Kozutsumi, Y., Tsubata, T., Ishida, H., Kiso, M.
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Journal Title
Bioorg.Med.Chem.Lett
Volume: 19
Pages: 5573-5
Related Report
Peer Reviewed
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[Journal Article] Synthesis of biotinylated sialoside to probe CD22-ligand interactions2009
Author(s)
Abdu-Allah, H.H.M., Watanabe, K., Hayashizaki, K., Iwayama, Y., Takematsu, H., Kozutsumi, Y., Tsubata, T., Ishida, H., Kiso, M.
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Journal Title
Tetrahedron Lett.
Volume: 50
Pages: 5573-5
Related Report
Peer Reviewed
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