| Project/Area Number |
20790372
|
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Immunology
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| Research Institution | Kyoto University |
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Principal Investigator |
SAKATA Daiji Kyoto University, 医学研究科, 研究員 (70456870)
|
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| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | mDia / アクチン / リンパ球 / 免疫 / 遺伝子欠損マウス / 細胞遊走 / 細胞骨格 / アレルギー |
|---|
| Research Abstract |
Actin protein are polymerized and work as a cytoskeleton in cells, and then regulates cell shape. mDia proteins are actin nucleating proteins, which consist of three types of mDia proteins, mDia1, mDia2, and mDia3. We made mice deficient in each type of mDia protein and examined roles of mDia proteins in the body. We found that certain immune responses are impaired in these mDia deficient mice.
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