| Project/Area Number |
20790373
|
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Immunology
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| Research Institution | Kyoto University |
|---|
Principal Investigator |
HAMAZAKI Yoko Kyoto University, 医学研究科, 助教 (10362477)
|
|---|
| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
|
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| Keywords | T細胞分化 / 胸腺 / 上皮細胞 / 胸腺上皮細胞 / クローディン / Aire / 免疫学 / 発生分化 / タイトジャンクション |
|---|
| Research Abstract |
The thymus is a central lymphoid organ crucial for developing T cells. Aire is involved in expressing promiscuous gene expression of various tissue specific antigens in thymic stromal cells, which enables self-reactive T cells to be deleted in the thymus. In the previous study, we demonstrated that cell-adhesion molecules, claudins, are specifically expressed in Aire+ stromal cells. In this study, we produced claudin-KO mice to analyze the function of claudins on inducing self tolerance or development of Aire+ stromal cells.
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