| Project/Area Number |
20790378
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Immunology
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| Research Institution | Keio University |
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Principal Investigator |
MORO Kazuyo Keio University, 医学部, 助教 (90468489)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 自然免疫 / ナチュラルヘルパー細胞 / NH細胞 / FALC / Th2サイトカイン / IL-33 / IL-25 / c-Kit / 寄生虫 / Sca-1 |
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| Research Abstract |
We found novel lymphoid tissue in mesentery, and named 'FALC' (fat-associated lymphoid cluster). We also identified unknown lymphoid cells in FALC which express c-Kit, Sca-1, IL-7R and IL-33R. These cells proliferate in response to IL-2 and produce large amounts of TH2 cytokines such as IL-5, IL-6 and IL-13. IL-5 and IL-6 regulate B-cell antibody production and self-renewal of B1 cells. After helminth infection and in response to IL-33, FALC Lin-c-Kit+Sca-1+ cells produce large amounts of IL-13, which leads to goblet cell hyperplasia-a critical step for helminth expulsion. In mice devoid of FALC Lin-c-Kit+Sca-1+ cells, such goblet cell hyperplasia was not induced. Thus, FALC Lin-c-Kit+Sca-1+ cells are TH2-type innate lymphocytes, and we propose that these cells be called 'natural helper cells'.
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