| Project/Area Number |
20790379
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Immunology
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| Research Institution | Hyogo College of Medicine |
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Principal Investigator |
NAKAHIRA Masakiyo Hyogo College of Medicine, 医学部, 助教 (60454758)
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| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 免疫学 / アレルギー・ぜんそく / シグナル伝達 / 発現制御 / 遺伝子発現制御 |
|---|
| Research Abstract |
In this project, I studied the mechanism underlying IL-13 production in Th1 cell-derived Super Th1 cell by focusing on the expression of Gata3 transcription factor. I first revealed that IL-13 production in Super Th1 cells is regulated at the level of transcription. I next demonstrated that Gata3 is induced in Th1 cells by costimulation of TCR, IL-2, and IL-18 in the presence of IL-4 and that Gata3 is necessary to activate Il13 transcription in Super Th1 cells. Moreover, ChIP assay verified that Gata3 binds to a CGRE motif on Il13 gene, which might induce Il13 expression in Super Th1 cells.
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