Effect of cognitive function mediated by NMDA receptor activation of new nootropic drug.
Project/Area Number |
20790398
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Applied pharmacology
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Research Institution | Tohoku University |
Principal Investigator |
MORIGUCHI Shigeki Tohoku University, 大学院・薬学研究科, 助教 (70374949)
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Project Period (FY) |
2008 – 2009
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Project Status |
Completed (Fiscal Year 2009)
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Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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Keywords | NMDA受容体 / 記憶学習 / CaMKII / PKC / アルツハイマー / アルツハイマー病 / nefiracetam / CaMキナーゼII / OBXマウス / galantamine / 認知機能 / α4β2型受容体 / ピロリドン誘導体 / mGluR5 |
Research Abstract |
In this present study, we demonstrated that nefiracetam mediates cognitive function through activation of CaM kinase II (Moriguchi et al., J. Neurochem. 2008), and nefiracetam augments the impairment of coginitive function through activation of CaM kinase II and PKC in olfactory bulbectomized mice (Moriguchi et al., J. Neurochem. 2009), and nefiracetam enhances glutamatergic system via presynaptic nicotinic acethylcholine receptors in rat cortical neurons (Moriguchi et al., Neuroscinece 2009), and galantamine mediates cognitive function through activation of CaM kinase II (Moriguchi et al., Hippocampus, 2009).
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Report
(3 results)
Research Products
(60 results)
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[Journal Article] Nobiletin improves brain ischemia-induced learning and memory deficits through stimulation of CaMKII and CREB phosphorylation.2009
Author(s)
Yui Yamamoto, Norifumi Shioda, Feng Han, Shigeki Moriguchi, Akira Nakajima, Akihito Yokosuka, Yoshihiro Mimaki, Yutaka Sashida, Tohru Yamakuni, Yasushi Ohizumi, Kohji Fukunaga
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Journal Title
Brain Res. 1295
Pages: 218-229
Related Report
Peer Reviewed
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[Journal Article] Generation and characterization of conditional heparin-binding EGF-like growth factor knockout mice2009
Author(s)
Atsushi Oyagi, Yasuhisa Oida, Kenichi Kakefuda, Masamitsu Shimazawa, Norifumi Shioda, Shigeki Moriguchi, Kiyoyuki Kitaichi, Daisuke Nanba, Kazumasa Yamaguchi, Yasuhide Furuta, Kohji Fukunaga, Shigeki Higashiyama, Hideaki Hara
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Nobiletin improves brain ischemia-induced learning and memory deficits through stimulation of CaMKII and CREB phosphorylation2009
Author(s)
Yui Yamamoto, Norifumi Shioda, Feng Han, Shigeki Moriguchi, Akira Nakajima, Akihito Yokosuka, Yoshihiro Mimaki, Yutaka Sashida, Tohru Yamakuni, Yasushi Ohizumi, Kohji Fukunaga
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Journal Title
Brain Research 1295
Pages: 218-229
Related Report
Peer Reviewed
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[Journal Article] Nobiletin, a citrus flavonoid with neurotrophic action, augments protein kinase A-mediated phosphorylation of the AMPA receptor subunit, GluR1, and the postsynaptic receptor response to glutamate in murine hippocampus.2008
Author(s)
Kentaro Matsuzaki, Kenichi Miyazaki, Seiichiro Sakai, Hiromu Yawo, Norihito Nakata, Shigeki Moriguchi, Kohji Fukunaga, Akihito Yokosuka, Yutaka Sashida, Yoshihiro Mimaki, Tohru Yamakuni, Yasushi Ohizumi
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Journal Title
Eur. J. Pharmacol. 578
Pages: 194-200
Related Report
Peer Reviewed
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[Journal Article] Nobiletin, a citrus flavonoid with neurotrophic action, augments protein kinase Amediated phosphorylation of the AMPA receptor subunit, GluR1, and the postsynaptic receptor response to glutamate in murine hippocampus2008
Author(s)
Kentaro Matsuzaki, Kenichi Miyazaki, Seiichiro Sakai, Hiromu Yawo Norihito Nakata, Shigeki Moriquchi, Kohji Fukunaga, Akihito Yokosuka, Yutaka Sashida, Yoshihiro Mimaki, Tohru Yamakuni and Yasushi Ohizumi
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Journal Title
European Journal of Pharmacology 151
Pages: 671-679
Related Report
Peer Reviewed
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[Presentation] Nobiletin-induced stimulation of CaMKII and CREB phosphorylation is associated with memory improvement after brain ischemia2009
Author(s)
Yui Yamamoto, Norifumi Shioda, Feng Han, Shigeki Moriguchi, Akira Nakajima, Akihito Yokosuka, Yoshihiro Mimaki, Yutaka Sashida, Tohru Yamakuni, Yasushi Ohizumi, Kohji Fukunaga
Organizer
22nd Biennial Meeting of the International Society for Neurochemistry
Place of Presentation
Busan, Korea
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[Presentation] Essential role of diacylglycerol kinase beta(DGKβ)in neurite spine formation, cognitive function, and memory2009
Author(s)
Yasuhito Shirai, Takeshi Kozuki, Kenichi Kakefuda, Shigeki Moriguchi, Atushi Oyagi, Kyoji Horie, Masamitsu Shimazawa, Kohji Fukunaga, Jun Takeda, Naoaki Saito, Hideaki Hara
Organizer
39th.Society for Neuroscience ; Annual Meeting
Place of Presentation
Chicago, USA
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