| Project/Area Number |
20790398
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied pharmacology
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| Research Institution | Tohoku University |
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Principal Investigator |
MORIGUCHI Shigeki Tohoku University, 大学院・薬学研究科, 助教 (70374949)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | NMDA受容体 / 記憶学習 / CaMKII / PKC / アルツハイマー / アルツハイマー病 / nefiracetam / CaMキナーゼII / OBXマウス / galantamine / 認知機能 / α4β2型受容体 / ピロリドン誘導体 / mGluR5 |
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| Research Abstract |
In this present study, we demonstrated that nefiracetam mediates cognitive function through activation of CaM kinase II (Moriguchi et al., J. Neurochem. 2008), and nefiracetam augments the impairment of coginitive function through activation of CaM kinase II and PKC in olfactory bulbectomized mice (Moriguchi et al., J. Neurochem. 2009), and nefiracetam enhances glutamatergic system via presynaptic nicotinic acethylcholine receptors in rat cortical neurons (Moriguchi et al., Neuroscinece 2009), and galantamine mediates cognitive function through activation of CaM kinase II (Moriguchi et al., Hippocampus, 2009).
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