| Project/Area Number |
20790416
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Laboratory medicine
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| Research Institution | Osaka Medical College |
|---|
Principal Investigator |
MATSUMURA Yoko Osaka Medical College, 医学部, 助教 (80388256)
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|---|
| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 臨床検査医学 / プロテオミクス / 関節炎 / シトルリン化タンパク / 関節リウマチ / 変形性関節症 / 質量分析 |
|---|
| Research Abstract |
In this study, we identified three proteins, citrullinated fibrinogen, citrullinated fibronectin, and citrullinated vimentin in synovial fluids derived from RA patients by proteomics based analysis. Besides, compared to synovial fluids from OA patients, α1acid glycoprotein and fibrinogen were found in higher levels and apolipoprotein A-I was found in lower level in synovial fluids from RA patients. It was thought that there was a possibility of a new arthritis diagnostic marker by combination of these proteins.
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