Chemosensitivity prediction of platinum-containing anticancer drugs with gene expression of copper transporter on cell membrane

• Project/Area Number: 20790482
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Gastroenterology
• Research Institution: Hirosaki University
• Principal Investigator: TAKAHATA Takenori Hirosaki University, 大学院・医学研究科, 助教 (20333726)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 上部消化器官学(食道、胃、十二指腸) / 薬剤感受性

Research Abstract

In cell line experiments, gene knockdown of ATP7A, ATP7B and hCTR1 by siRNA showed no statistically significant difference in chemosensitivity of cisplatin and oxaliplatin. And in clinical sample experiments, there was no significant difference between cancer tissue and normal tissue from cancer-bearing patients in DNA methylation, point mutation and mRNA expression of these copper transporter genes.

Research Products

• [Journal Article] Intratracheal delivery of CX3CL1-expressing mesenchymal stem cells to multiple lung tumors (2009)
  • Author(s): Hong Xin, Ruowen Sun, Masahiko Kanehira, Takenori Takahata, Jugoh Itoh, Hiroyuki Mizoguchi, Yasuo Saijo
  • Journal Title: Mol Med 15(9-10) Pages: 321-327
  • Peer Reviewed
• [Journal Article] Intratracheal delivery of CX3CL1-expressing mesenchymal stem cells to multiple lung tumors (2009)
  • Author(s): Hong Xin, Ruowen Sun, Masahiko Kanehira, Takenori Takahata, Jugoh Itoh, Hiroyuki Mizoguchi, Yasuo Saijo
  • Journal Title: Molecular Medicine 15 Pages: 321-327
  • Peer Reviewed
• [Journal Article] Disturbance of the growth hormone-like growth factor-1 axis associated with poor performance status in patients with solid tumors (2009)
  • Author(s): Isamu Okamoto, Masaki Munakata, Masaki Miyazaki, Takenori Takahata, Yasushi Takamatsu, Osamu Muto, Kazuhiko Koike, Kunihiko Ishitani, Taketo Mukaiyama, Yuh Sakata. Kazuo Tamura
  • Journal Title: Japanese Journal of Clinical Oncology (Epub)
• [Journal Article] Influence of cancer-related gene polymorphisms on clinicopathological features in colorectal cancer (2008)
  • Author(s): Gen Yoshiya, Takenori Takahata, Naoyuki Hanada, Kazuhiro Suzuki, Atsushi Ishiguro, Masato Saito, Mutsuo Sasaki, Shinsaku Fukuda
  • Journal Title: J Gastroenterol Hepatol 23(6) Pages: 948-953
  • Peer Reviewed
• [Journal Article] Disturbance of the growth hormone-like growth factor-1 axis associated with poor performance status in patients with solid tumors
  • Author(s): Isamu Okamoto, Masaki Munakata, Masaki Miyazaki, Takenori Takahata, Yasushi Takamatsu, Osamu Muto, Kazuhiko Koike, Kunihiko Ishitani, Taketo Mukaiyama, Yuh Sakata, Kazuo Tamura
  • Journal Title: Jpn J Cllin Oncol (in press)
  • Peer Reviewed
• [Presentation] ヒト大腸癌細胞株におけるKeap1プロモーター領域のメチル化 (2009)
  • Author(s): 花田直之、高畑武功、伊東重豪、孫若文、鈴木一広、鬼島宏、伊東健、福田眞作、西條康夫
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-02
• [Presentation] 日本人悪性リンパ腫患者における臨床病理学的因子に影響する遺伝子多型の検索 (2009)
  • Author(s): 高畑武功、伊東重豪、花田直之、鈴木一広、孫若文、石黒敦、坂田優、西條康夫
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-01
• [Presentation] マウス肺の成長過程における肺幹細胞の動態解析 (2009)
  • Author(s): 孫若文、辛紅、高畑武功、伊東重豪、鬼島宏、貫和敏博、西條康夫
  • Organizer: 第49回日本呼吸器学会学術講演会
  • Place of Presentation: 東京
  • Year and Date: 2009-06-12
• [Presentation] 間葉系幹細胞は生体の腫瘍増殖を促進させる (2008)
  • Author(s): 鈴木一広、折口真人、兼平雅彦、孫若文、花田直之、高畑武功、伊東重豪、西條康夫
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-29
• [Presentation] 間葉系幹細胞は生体の腫瘍増殖を促進させる (2008)
  • Author(s): 鈴木一広、折口真人、兼平雅彦、孫若文、花田直之、高畑武功、伊東重豪、西條康夫
  • Organizer: 日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-29