The role of helper T cells in Helicobacter infection

Research Project

Project/Area Number	20790494
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Gastroenterology
Research Institution	Kobe University
Principal Investigator	TAKAGAWA Tetsuya Kobe University, 医学研究科, 医学研究員 (20444614)
Project Period (FY)	2008 – 2009
Project Status	Completed (Fiscal Year 2009)
Budget Amount *help	¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000) Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2008: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords	感染症 / T細胞 / ヘリコバクター属細菌 / ピロリ / 胃がん / ガストリントランスジェニックマウス / サイトカイン
Research Abstract	The aim of this study is to clarify the role of CD4+ T cells in the development of H.pylori induced gastric cancer. It has been revealed gradually that Th1 type immune responses play critical roles in the development of gastritis and gastric cancer by our studies. It is very important to clarify the detailed mechanisms of host immune responses against H.pylori infection, which leads to the advancement in the treatment strategy for H.pylori related diseases, such as the immunotherapy and the control of oncogenesis.

Report

(3 results)