| Project/Area Number |
20790530
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Circulatory organs internal medicine
|
|---|
| Research Institution | Kobe University |
|---|
Principal Investigator |
YASUDA Tomoyuki Kobe University, 医学研究科, 医学研究員 (20457047)
|
|---|
| Research Collaborator |
ISHIDA Tatsuro 神戸大学, 大学院・医学研究科, 准教授 (00379413)
|
|---|
| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | 循環器・高血圧 / 細胞・組織 / 内科 / 血管内皮 / 血管新生 / 動脈硬化 / 循環器 / 接着分子 |
|---|
| Research Abstract |
Our aim is to analyze the effect of ESAM on the progression of atherosclerosis. We generated ESAM / apoE double knockout mice and analyzed atherosclerosis lesion size. We also generated ESAM expression reduced endothelial cell by SiRNA method. We found that ESAM inhibition reduced the invasion of monocytes through endothelial cells and ESAM deficiency reduced atherosclerosis in apoE knockout mice. ESAM inhibition might be a novel therapy for preventing atherosclerosis.
|
