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The Effects of Steroid Hormone to Heart.

Research Project

Project/Area Number 20790537
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Circulatory organs internal medicine
Research InstitutionKumamoto University

Principal Investigator

YAMAMURO Megumi  Kumamoto University, 大学院・生命科学研究部, 助教 (50457587)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords循環器・高血圧 / 内科 / 生理学 / 病理学 / 細胞・組織
Research Abstract

In basic study, we reported that Aldosterone, but not angiotensin II, reduced ACE2 mRNA levels and increased ACE mRNA levels in rat cardiomyocytes via mineralocorticoid receptor. Aldosterone might play an important role in cardiac remodeling by upregulating ACE and downregulating ACE2 levels. (Circulation Journal 2008)
In clinical study, we reported that a plasma BNP level is a significant independent predictive factor for pump failure death in myocardial infarction and non-ischemic heart failure patients. Estimated GFR is a significant independent predictive factor for sudden cardiac death in myocardial infarction patients.(J Cardiol. 2010 ; 55(1) : 55-64.)

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (43 results)

All 2011 2010 2009 2008

All Journal Article (13 results) (of which Peer Reviewed: 13 results) Presentation (21 results) Book (9 results)

  • [Journal Article] C/EBP Homologous Protein Deficiency Attenuates Myocardial Reperfusion Injury by Inhibiting Myocardial Apoptosis and Inflammation.2011

    • Author(s)
      Miyazaki Y, Kaikita K, Endo M, Horio E, Miura M, Tsujita K, Hokimoto S, Yamamuro M, Iwawaki T, Gotoh T, Ogawa H, Oike Y.
    • Journal Title

      Arterioscler Thromb Vasc Biol. in press

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] C/EBP Homologous Protein Deficiency Attenuates Myocardial Reperfusion Injury by Inhibiting Myocardial Apoptosis and Inflammation.2011

    • Author(s)
      Miyazaki Y
    • Journal Title

      Arterioscler Thromb Vasc Biol.

      Volume: (In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Digital assessment of endothelial function and ischemic heart disease in women.2010

    • Author(s)
      Matsuzawa Y, Sugiyama S, Sugamura K, Nozaki T, Ohba K, Konishi M, Matsubara J, Sumida H, Kaikita K, Kojima S, Nagayoshi Y, Yamamuro M, Izumiya Y, Iwashita S, Matsui K, Jinnouchi H, Kimura K, Umemura S, Ogawa H.
    • Journal Title

      J Am Coll Cardiol. 55(16)

      Pages: 1688-1696

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Digital assessment of endothelial function and ischemic heart disease in women.2010

    • Author(s)
      Matsuzawa Y
    • Journal Title

      Journal of the American College of Cardiology 55

      Pages: 1688-1696

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical factors affecting serum potassium concentration in cardio-renal decompensation syndrome.2010

    • Author(s)
      Ueno H
    • Journal Title

      International Journal of Cardiology 138

      Pages: 174-181

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pump failure death and sudden cardiac death in patients with cardiac dysfunction : a search for prognostic predictive factors-a long-term follow-up study.2009

    • Author(s)
      Usuku H, Nakayama M, Sumida H, Yamamuro M, Izumiya Y, Suzuki S, Kusuhara K, Ueno H, Sugiyama S, Yoshimura M, Ogawa H.
    • Journal Title

      J Cardiol. 20;55(1)

      Pages: 55-64

    • NAID

      10027051490

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ischemic heart disease.2009

    • Author(s)
      Yamamuro M, Ogawa H.
    • Journal Title

      Nippon Rinsho.Review. 67(4)

      Pages: 764-770

    • NAID

      40016565824

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinical factors affecting serum potassium concentration in cardio-renal decompensation syndrome.2008

    • Author(s)
      Ueno H, Yoshimura M, Nakayama M, Yamamuro M, Nishijima T, Kusuhara K, Nagayoshi Y, Kojima S, Kaikita K, Sumida H, Sugiyama S, Ogawa H.
    • Journal Title

      Int J Cardiol. 21;138(2)

      Pages: 174-181

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Aldosterone, but not angiotensin II, reduces angiotensin converting enzyme 2 gene expression levels in cultured neonatal rat cardiomyocytes.2008

    • Author(s)
      Yamamuro M, Yoshimura M, Nakayama M, Abe K, Sumida H, Sugiyama S, Saito Y, Nakao K, Yasue H, Ogawa H.
    • Journal Title

      Circ J. 72(8)

      Pages: 1346-1350

    • NAID

      110006835739

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The synergistic combined effect of anemia with high plasma levels of B-type natriuretic peptide significantly predicts an enhanced risk for major adverse cardiac events.2008

    • Author(s)
      Ueno H, Nakayama M, Kojima S, Kusuhara K, Nagayoshi Y, Yamamuro M, Nishijima T, Usuku H, Kaikita K, Sumida H, Yamabe H, Sugiyama S, Yoshimura M, Ogawa H.
    • Journal Title

      Heart Vessels. 23(4)

      Pages: 243-248

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinical factors affecting serum potassium concentration in cardio-renal decomoensation syndrome2008

    • Author(s)
      Ueno H
    • Journal Title

      Int J Cardiol. 18(In Press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aldosterone, but not angiotensin II, reduces angiotensin converting enzyme 2 gene expression levels in cultured neonatal rat cardi omyocytes2008

    • Author(s)
      Yamamuro M
    • Journal Title

      Circulation Journal 72

      Pages: 1346-1350

    • NAID

      110006835739

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The synergistic combined effect of anemia with high plasma levels of B-type natriuretic peptide significantly predicts an enhanced risk for maior adverse cardiac events2008

    • Author(s)
      Ueno H
    • Journal Title

      Heart Vessels 23

      Pages: 243-248

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Effect of Aldosterone and Sodium on Cardiomyocytes.2010

    • Author(s)
      Yamamuro M
    • Organizer
      日本心臓血管内分泌代謝学会学術総会
    • Place of Presentation
      奈良県新公会堂
    • Year and Date
      2010-04-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] High Apolopoprotein C3and Low Apolopoprotein A1 Levels But not TG and HDL-CHO Enhanced the Risk of Cardiovascular Re-attacks in Patients with Heart Failure2010

    • Author(s)
      山室恵
    • Organizer
      第74回日本循環器学会
    • Place of Presentation
      京都国際会議場
    • Year and Date
      2010-03-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] Effect of Aldosterone and Sodium on Cardiomyocytes.2010

    • Author(s)
      Yamamuro M, Nakayama M, Yoshimura M, Ogawa H.
    • Organizer
      2010年第14回日本心臓血管内分泌代謝学会学術総会
    • Place of Presentation
      奈良県新公会堂
    • Related Report
      2010 Final Research Report
  • [Presentation] Digital Assessment of Endothelial Function Predicts Coronary Plaque Vulnerability in High Risk Patients Suspected Coronary Artery Disease.2010

    • Author(s)
      Matsuzawa Y, Sugiyama S, Sumida H, Sugamura K, Nozaki T, Oba K, Kaikita K, Kojima S, Nagayoshi Y, Yamamuro M, Izumiya Y, Sakamoto K, Konishi M, Matsubara J, Akiyama E, Iwashita S, Matsui K, Jinnouchi H, Kimura K, Umemura S, Ogawa H.
    • Organizer
      American College of Cardiology 2010, 59th Annual Scientific Session
    • Place of Presentation
      Atlanta, GA USA
    • Related Report
      2010 Final Research Report
  • [Presentation] Low Apolopoprotein C3and A1 Levels Enhanced Risk of Cardiovascular Re-attacks in Patients with Heart Failure.2010

    • Author(s)
      Yamamuro M, Takashio S, Izumiya Y, Sakamoto K, Tsujita K, Kaikita K, Hokimoto S, Sumida H, Sugiyama S, Ogawa H.
    • Organizer
      第74回日本循環器学会総会・学術集会
    • Place of Presentation
      京都国際会議場
    • Related Report
      2010 Final Research Report
  • [Presentation] Interpretation of B-type Natriuretic Peptide of Elderly Population in a Sanatorium.2010

    • Author(s)
      Kusuhara K, Fukuda M, Yamamuro M, Nakayama M, Ogawa H.
    • Organizer
      第74回日本循環器学会総会・学術集会
    • Place of Presentation
      京都国際会議場
    • Related Report
      2010 Final Research Report
  • [Presentation] Paradoxical Angina Pectoris : Occurrence of Myocardial Ischemic Attack with Paradoxically Increasing Coronary Blood Supply through Non-obstructive Coronary Artery.2010

    • Author(s)
      Ohba K, Sugiyama S, Sugamura K, Nozaki T, Matsuzawa Y, Matsubara J, Konishi M, Akiyama E, Sumida H, Kaikita K, Kojima S, Nagayoshi Y, Yamamuro M, Izumiya Y, Sakamoto K, Hokimoto S, Yamabe H, Ogawa H.
    • Organizer
      第74回日本循環器学会総会・学術集会
    • Place of Presentation
      京都国際会議場
    • Related Report
      2010 Final Research Report
  • [Presentation] Aldosterone, but not angiotensin II, reduces angiotensin converting enzyme 2 gene expression levels in cultured neonatal rat cardi omyocytes2009

    • Author(s)
      山室恵
    • Organizer
      第3回日本循環器学会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2009-03-21
    • Related Report
      2008 Annual Research Report
  • [Presentation] Digital Assessment of Endothelial Function Predicts Coronary Plaque Vulnerability in High Risk Patients Suspected Coronary Artery Disease.2009

    • Author(s)
      Matsuzawa Y, Sugiyama S, Sumida H, Sugamura K, Nozaki T, Ohba K, Kaikita K, Kojima S, Nagayoshi Y, Yamamuro M, Izumiya Y, Sakamoto K, Konishi M, Matsubara J, Akiyama E, Iwashita S, Matsui K, Jinnouchi H, Kimura K, Umemura S, Ogawa H.
    • Organizer
      American Heart Association the 82nd Scientific Sessions
    • Place of Presentation
      Orlando, FL USA
    • Related Report
      2010 Final Research Report
  • [Presentation] Paradoxical angina pectoris: occurrence of myocardial ischemic attack with paradoxically increasing coronary blood supply through non-obstructive coronary artery.2009

    • Author(s)
      Ohba K, Sugiyama S, Sugamura K, Nozaki T, Matsuzawa Y, Matsubara J, Konishi M, Akiyama E, Sumida H, Kaikita K, Kojima S, Nagayoshi Y, Yamamuro M, Izumiya Y, Sakamoto K, Hokimoto S, Yamage H, Ogawa H.
    • Organizer
      American Heart Association the 82nd Scientific Sessions
    • Place of Presentation
      Orlando, FL USA
    • Related Report
      2010 Final Research Report
  • [Presentation] Digital Assessment of Endothelial Function and Ischemic Heart Disease in Women.2009

    • Author(s)
      Matsuzawa Y, Sugiyama S, Sumida H, Sugamura K, Nozaki T, Ohba K, Konishi M, Matsubara J, Kaikita K, Kojima S, Nagayoshi Y, Yamamuro M, Izumiya Y, Iwashita S, Matsui K, Kimura K, Umemura S, Ogawa H.
    • Organizer
      XV International Symposium on Atherosclerosis 2009
    • Place of Presentation
      Boston, MA USA
    • Related Report
      2010 Final Research Report
  • [Presentation] Digital Assessment of Endothelial Function Predicts Coronary Plaque Vulnerability in High Risk Patients Suspected Coronary Artery Disease.2009

    • Author(s)
      Matsuzawa Y, Sugiyama S, Sumida H, Sugamura K, Nozaki T, Ohba K, Kaikita K, Kojima S, Nagayoshi Y, Yamamuro M, Izumiya Y, Sakamoto K, Konishi M, Matsubara J, Akiyama E, Iwashita S, Matsui K, Jinnouchi H, Kimura K, Umemura S, Ogawa H.
    • Organizer
      XV International Symposium on Atherosclerosis 2009
    • Place of Presentation
      Boston, MA USA
    • Related Report
      2010 Final Research Report
  • [Presentation] Aldosterone, but Not Angiotensin II, Reduces Angiotensin Converting Enzyme 2 Gene Expression Levels in Cultured Neonatal Rat Cardiomyocytes.2009

    • Author(s)
      Yamamuro M, Sakanashi T, Nakayama M, Yoshimura M, Ogawa H.
    • Organizer
      第73回日本循環器学会総会学術集会
    • Place of Presentation
      大阪国際会議場
    • Related Report
      2010 Final Research Report
  • [Presentation] Post Procedural Creatinine Increase is Associated with Endothelial Dysfunction in Patients with Early Stage of Chronic Kidney Disease.2009

    • Author(s)
      Ohba K, Sugiyama S, Matsubara J, Matsuzawa T, Konishi M, Nozaki T, Morihisa K, Uemura T, Tanaka Y, Oe Y, Sugamura K, Sakamoto K, Yamamuro M, Nagayoshi Y, Kojima S, Izumiya Y, Kaikita K, Soejima H, Sumida H, Yamabe H, Ogawa H.12.Sumida H, Sugiyama S, Matsuzawa Y, Kaikita K, Kojima S, Nagayoshi Y, Yamamuro M, Izumiya Y, Sakamoto K, Ohba K, Nozaki T, Sugamura K, Konishi M, Hokimoto S, Ogawa H.
    • Organizer
      第73回日本循環器学会総会学術集会
    • Place of Presentation
      大阪国際会議場
    • Related Report
      2010 Final Research Report
  • [Presentation] Plasminogen Activator Inhibitor 1 Gene Expression in Platelets is Significantly Correlated with Glucose and Lipid Metabolism and with Occurrence of Acute Coronary Syndrome.2009

    • Author(s)
      Nakayama M, Yamamuro M, Kusuhara K, Ueno H, Usuku H, Ogawa H.
    • Organizer
      第73回日本循環器学会総会学術集会
    • Place of Presentation
      大阪国際会議場
    • Related Report
      2010 Final Research Report
  • [Presentation] Direct effects of aldosterone on cardiomyocytes in the presence of normal and elevated extracellular sodium2008

    • Author(s)
      山室恵
    • Organizer
      第12回日本心血管内分泌代謝学会
    • Place of Presentation
      熊本国際交流会館
    • Year and Date
      2008-11-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] Direct effects of aldosterone on cardiomyocytes in the presence of normal and elevated extracellular sodium2008

    • Author(s)
      山室恵
    • Organizer
      第12回Molecular Cardiovascular Conference
    • Place of Presentation
      北海道キロロ
    • Year and Date
      2008-09-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] Plasminogen Activator Inhibitor 1 Gene Expression in Platelets is Significantly Correlated with Glucose and Lipid Metabolism and with Occurrence of Acute Coronary Syndrome.2008

    • Author(s)
      Nakayama M, Yamamuro M, Kusuhara K, Ueno H, Usuku H, Ogawa H.
    • Organizer
      2008年度American Heart Association Scientific Sessions 2008
    • Place of Presentation
      New Orleans, Louisiana USA
    • Related Report
      2010 Final Research Report
  • [Presentation] Abdominal Obesity is a Significant Determinant of Endothelial Dysfunction in High Risk Patients with or without Metabolic Syndrome.2008

    • Author(s)
      Matsuzawa Y, Sugiyama S, Nozaki T, Sugamura K, Yamamuro M, Nagayoshi Y, Kojima S, Kaikita K, Sumida H, Ogawa H.
    • Organizer
      第72回日本循環器学会総会・学術集会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2010 Final Research Report
  • [Presentation] Synergistic Interaction of Plasma BNP and Glucose Levels for Enhanced Risk for Cardiovascular Re-attacks in Patients with Heart Failure.2008

    • Author(s)
      Yamamuro M, Nakayama M, Ueno H, Kusuhara K, Usuku H, Nishijima T, Suzuki S, Sugiyama S, Ogawa H.
    • Organizer
      第72回日本循環器学会総会・学術集会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2010 Final Research Report
  • [Presentation] Improvement of Endothelial Function is a Potential Clinical Target for Heart Failure Patients with Systolic or Diastolic Dysfunction.2008

    • Author(s)
      Matsuzawa Y, Sugiyama S, Nozaki T, Sugamura K, Yamamuro M, Nagayoshi Y, Kojima S, Kaikita K, Sumida H, Ogawa H.
    • Organizer
      第72回日本循環器学会総会・学術集会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2010 Final Research Report
  • [Book] 虚血性心疾患.67(4)2009

    • Author(s)
      山室惠, 小川久雄
    • Publisher
      日本臨牀
    • Related Report
      2010 Final Research Report
  • [Book] 狭心症・心筋梗塞.67(7)2009

    • Author(s)
      山室惠, 小川久雄
    • Publisher
      日本臨牀
    • Related Report
      2010 Final Research Report
  • [Book] 選択的アルドステロンブロッカーのすべて 心血管イベントにおける選択的アルドステロンブロッカーの抗凝固作用をみる(猿渡享男 編)2009

    • Author(s)
      山室惠, 小川久雄
    • Publisher
      先端医学社
    • Related Report
      2010 Final Research Report
  • [Book] 高血圧下-日本における最新の研究動向 狭心症・心筋梗塞 臨床編2009

    • Author(s)
      山室惠, 小川久雄
    • Publisher
      日本臨牀
    • Related Report
      2010 Final Research Report
  • [Book] 重症心不全の予防と治療 ジギタリス、利尿剤(北風雅史編)2009

    • Author(s)
      山室惠, 小川久雄
    • Publisher
      中外医学社
    • Related Report
      2010 Final Research Report
  • [Book] CKD×糖尿病 の薬物療法・服薬管理Q&A(4).59(12)2008

    • Author(s)
      山室惠, 杉山正悟, 小川久雄
    • Publisher
      薬局
    • Related Report
      2010 Final Research Report
  • [Book] 心不全のバイオマーカーと治療戦略.26(11)2008

    • Author(s)
      山室惠, 小川久雄
    • Publisher
      カレントテラピー
    • Related Report
      2010 Final Research Report
  • [Book] カレントセラピー心不全の最近の動向と治療心不全のバイオマーカーと治療2008

    • Author(s)
      山室恵
    • Publisher
      ライフメデイコム
    • Related Report
      2008 Annual Research Report
  • [Book] 薬局CKD×糖尿病2008

    • Author(s)
      山室恵
    • Publisher
      南山堂
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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