Effect of intravenous administration of immunoglobulin on myocardial reperfusion injury.

Research Project

Project/Area Number	20790547
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Circulatory organs internal medicine
Research Institution	Keio University
Principal Investigator	UENO Koji Keio University, 医学部, 助教 (90348631)
Project Period (FY)	2008 – 2009
Project Status	Completed (Fiscal Year 2009)
Budget Amount *help	¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000) Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords	免疫グロブリン / 虚血再潅流 / 接着因子 / 補体 / 好中球 / 虚血再潅流傷害 / 左室リモデリング
Research Abstract	Intravenous administration of immunoglobulin (IVIG) pretreatment before ischemia/reperfusion (I/R) attenuated microcirculatory disturbance and inflammatory response, and preserved left ventricular function. IVIG may be effective as an adjunctive therapy to myocardial reperfusion injury, possibly through inhibition of complementary system that plays an important role during the early stage of inflammatory cascades in I/R.

Report

(3 results)