Effect of intravenous administration of immunoglobulin on myocardial reperfusion injury.
| Project/Area Number |
20790547
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Keio University |
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Principal Investigator |
UENO Koji Keio University, 医学部, 助教 (90348631)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 免疫グロブリン / 虚血再潅流 / 接着因子 / 補体 / 好中球 / 虚血再潅流傷害 / 左室リモデリング |
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| Research Abstract |
Intravenous administration of immunoglobulin (IVIG) pretreatment before ischemia/reperfusion (I/R) attenuated microcirculatory disturbance and inflammatory response, and preserved left ventricular function. IVIG may be effective as an adjunctive therapy to myocardial reperfusion injury, possibly through inhibition of complementary system that plays an important role during the early stage of inflammatory cascades in I/R.
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Report
(3 results)
Research Products
(2 results)
