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Bone-marrow mesenchymal stem cell therapy for vascular repair

Research Project

Project/Area Number 20790554
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Circulatory organs internal medicine
Research InstitutionShowa University

Principal Investigator

YOSHITAKA Lso  Showa University, 医学部, 助教 (60384244)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords血管病 / 間葉系幹細胞 / 血管再生 / 動脈硬化 / 血管リモデリング / 骨髄間葉系幹細胞
Research Abstract

The aim of this study was to develop bone-marrow mesenchymal stem cell (MSC) therapy for repair of atherosclerotic vascular diseases. Similar to endothelial progenitors, MSCs were mobilized into peripheral circulation in patients with acute myocardial infarction, and cultured MSCs differentiated into vascular lineage cells. In rodent vascular injury model, local administration of MSCs suppressed neointimal formation and promoted re-endothelialization. MSC-based vascular intervention appears to be a promising approach for treatment of atherosclerosis and restenosis after vascular injury.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (16 results)

All 2010 2009 2008

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (9 results)

  • [Journal Article] Impact of implanted bone marrow progenitor cell composition on limb salvage after cell implantation in patients with critical limb ischemia2010

    • Author(s)
      Iso Y, Soda T, Sato T, Sato R, Kusuyama T, Omori Y, Shoji M, Koba S, Katagiri T, Kobayashi Y, Suzuki H
    • Journal Title

      Atherosclerosis 209

      Pages: 167-72

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Preventive effects of heregulin-beta1 on macrophage foam cell formation and atherosclerosis2009

    • Author(s)
      Xu G, Watanabe T, Iso Y, Koba S, Sakai T, Nagashima M, Arita S, Hongo S, Ota H, Kobayashi Y, Miyazaki A, Hirano T
    • Journal Title

      Circ Res 105

      Pages: 500-10

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increased plasma urotensin-II and carotid atherosclerosis are associated with vascular dementia2009

    • Author(s)
      Ban Y, Watanabe T, Suguro T, Matsuyama TA, Iso Y, Sakai T, Sato R, Idei T, Nakano Y, Ota H, Miyazaki A, Kato N, Hirano T, Ban Y, Kobayashi Y
    • Journal Title

      Atheroscler Thromb 16

      Pages: 179-87

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Serum hepcidin-20 is elevated during the acute phase of myocardial infarction2009

    • Author(s)
      Suzuki H, Toba K, Kato K, Ozawa T, Tomosugi N, Higuchi M, Kusuyama T, Iso Y, Kobayashi N, Yokoyama S, Fukuda N, Saitoh H, Akazawa K, Aizawa Y
    • Journal Title

      Tohoku J Exp Med 218

      Pages: 93-8

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] High-dose granulocyte-colony stimulating factor promotes neointimal hyperplasia in the early phase and inhibits neointimal hyperplasia in the late phase after vascular injury2008

    • Author(s)
      Shoji M, Iso Y, Kusuyama T, Omori Y, Soda T, Tsunoda F, Sato T, Koba S, Geshi E, Kobayashi Y, Katagiri T, Suzuki H
    • Journal Title

      Circ J 72

      Pages: 1885-93

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Elevation of matrix metalloproteinases and interleukin-6 in the culprit coronary artery of myocardial infarction2008

    • Author(s)
      Suzuki H, Kusuyama T, Sato R, Yokota Y, Tsunoda F, Sato T, Shoji M, Iso Y, Koba S, Katagiri T
    • Journal Title

      Eur J Clin Invest 38

      Pages: 166-73

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] G-CSF after myocardial infarction accelerates angiogenesis and reduces fibrosis in swine2008

    • Author(s)
      Sato T, Suzuki H, Kusuyama T, Omori Y, Soda T, Tsunoda F, Shoji M, Iso Y
    • Journal Title

      Int J Cardiol 127

      Pages: 166-173

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Presentation] CD271陽性骨髄間葉系幹細胞の向血管再生能と心筋梗塞後末梢血動員2010

    • Author(s)
      礒良崇, 他
    • Organizer
      日本再生医療学会
    • Place of Presentation
      広島
    • Year and Date
      2010-03-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] CD271 Identifies Human Bone Marrow Stem/Progenitor Cells with a Proangiogenic Potential and Circulating Progenitor Cells Mobilized after Acute Myocardial Infarction2010

    • Author(s)
      Yoshitaka Iso, et al.
    • Organizer
      American College of Cardiology
    • Place of Presentation
      Atlanta(米国)
    • Year and Date
      2010-03-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] CD271 Identifies Human Bone Marrow Stem/Progenitor Cells with a Proangiogenic Potential and Circulating Progenitor Cells Mobilized after Acute Myocardial Infarction2010

    • Author(s)
      Yoshitaka Iso, et al
    • Organizer
      American College of Cardiology 2010
    • Place of Presentation
      Atlanta, U.S. A
    • Related Report
      2009 Final Research Report
  • [Presentation] Mobilization of Mesenchymal stem/progenitor cells after acute myocardial infarction2009

    • Author(s)
      礒良崇
    • Organizer
      日本循環器学会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2009-03-22
    • Related Report
      2008 Annual Research Report
  • [Presentation] Impact of erythroblasts in bone marrow cells on limb salvage after cell implantation in patients with critical limb ischemia2009

    • Author(s)
      Yoshitaka Iso, et al
    • Organizer
      European Society of Cardiology 2009
    • Place of Presentation
      Barcelona, Spain
    • Related Report
      2009 Final Research Report
  • [Presentation] Cellular Composition in Bone Marrow Cells may Influence Limb Salvage after Cell Implantation in Patients with Critical Limb Ischemia2009

    • Author(s)
      Yoshitaka Iso, et al
    • Organizer
      第41回日本動脈硬化学会シンポジウム4
    • Place of Presentation
      下関
    • Related Report
      2009 Final Research Report
  • [Presentation] Impact of Erythoid progenitors in bone marrow cells on limb salvage after cell implantation in patients with critical limb ischemia2009

    • Author(s)
      Yoshitaka Iso, et al
    • Organizer
      第8回日本再生医療学会
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Presentation] Circulating progenitors, angiotensinII and renal function in the elderly2009

    • Author(s)
      Yoshitaka Iso, et al
    • Organizer
      第73回日本循環器学会
    • Place of Presentation
      大阪
    • Related Report
      2009 Final Research Report
  • [Presentation] Mobilization of Mesenchymal stem/progenitor cells after acute myocardial infarction2009

    • Author(s)
      Yoshitaka Iso, et al
    • Organizer
      第73回日本循環器学会
    • Place of Presentation
      大阪
    • Related Report
      2009 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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