| Project/Area Number |
20790554
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Showa University |
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Principal Investigator |
YOSHITAKA Lso Showa University, 医学部, 助教 (60384244)
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| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 血管病 / 間葉系幹細胞 / 血管再生 / 動脈硬化 / 血管リモデリング / 骨髄間葉系幹細胞 |
|---|
| Research Abstract |
The aim of this study was to develop bone-marrow mesenchymal stem cell (MSC) therapy for repair of atherosclerotic vascular diseases. Similar to endothelial progenitors, MSCs were mobilized into peripheral circulation in patients with acute myocardial infarction, and cultured MSCs differentiated into vascular lineage cells. In rodent vascular injury model, local administration of MSCs suppressed neointimal formation and promoted re-endothelialization. MSC-based vascular intervention appears to be a promising approach for treatment of atherosclerosis and restenosis after vascular injury.
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