Analysis of the susceptibility gene for severe pneumonia with S.pneumoniae

Research Project

Project/Area Number	20790577
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Respiratory organ internal medicine
Research Institution	Toho University
Principal Investigator	KIMURA Soichiro Toho University, 医学部, 助教 (60408870)
Project Period (FY)	2008 – 2010
Project Status	Completed (Fiscal Year 2010)
Budget Amount *help	¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords	肺炎球菌 / Genotype / 肺炎 / マウス / Genotyping
Research Abstract	I explored the disease-susceptible genes associated with severe pneumonia with Streptococcus pneumoniae in mouse model. I identified candidate region within 10cM on chromosome 1 by using linkage analysis with CBA/J x C57B6/J F(2) intercross mouse. In this region, I confirmed possible disease-susceptibility-related genes such as immunoglobulin and apoptosis.