Role of the endothelial progenitor cells in the pathophysiology in kidney failure and the effect of injection of high functional endothelial progenitor cells in kidney failure.
| Project/Area Number |
20790584
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Kidney internal medicine
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
NAKAGAWA Naoki Asahikawa Medical College, 医学部, 特任助教 (10451460)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 腎臓学 / 再生医療 / 腎不全 / プロスタノイド |
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| Research Abstract |
We have recently reported that the mice of the specific deletion of prostaglandin I2 receptor (IP) in bone marrow cells is used as endothelial progenitor cells (EPCs) dysfunction model. We investigated the condition is whether the renal failure worsened, using the mice of the specific deletion of IP in bone marrow cells (BMCs). We examined renal function and histological change in models of renal artery ischemia-reperfusion, ureteral ligation, and renal nephrectomy. Among the three models, in renal artery ischemia-reperfusion model, the serum creatinine levels were tend to higher, but no significant, in mice of the specific deletion of IP in BMCs compared with mice of the transfused wild-type EPCs in BMCs.
In the future, we will investigate the ischemic conditions in increasing the number of animals, and examine the changes in functional analysis, as well as ureteral ligation model and nephrectomy model. Furtheremore, we will clarify the role of the EPCs in the pathophysiology in kidney failure and the effect of injection of high functional EPCs in kidney failure.
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Report
(4 results)
Research Products
(13 results)
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[Journal Article] A Case of Idiopathic Systemic Capillary Leak Syndrome with High Serum Levels of G-CSF on Exacerbation.2011
Author(s)
Nakagawa N, Ota H, Tanabe Y, Kabara M, Matsuki M, Chind J, Sakamoto N, Fujino T, Takehara N, Takeuchi T, Kawabe J, Sato N, Kawamura Y, Fukuhara T, Ikuta K, Kikuchi K, Hasebe N
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Journal Title
Intern Med 50
Pages: 597-600
NAID
Related Report
Peer Reviewed
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[Journal Article] Prostaglandin I2 promotes recruitment of endothelial progenitor cells and limits vascular remodeling.2010
Author(s)
Kawabe J, Yuhki K, Okada M, Kanno T, Yamauchi A, Tashiro N, Sasaki T, Okumura S, Nakagawa N, Aburakawa Y, Takehara N, Fujino T, Hasebe N, Narumiya S, Ushikubi F.
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Journal Title
Arteriosclerosis, thrombosis, and vascular biology 30
Pages: 464-470
Related Report
Peer Reviewed
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