Identification of the origin of prion infection
Project/Area Number |
20790608
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Neurology
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Research Institution | Tohoku University |
Principal Investigator |
KOBAYASHI Atsushi Tohoku University, 大学院・医学系研究科, 助教 (50431507)
|
Project Period (FY) |
2008 – 2009
|
Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 神経病態生化学 / プリオン / クロイツフェルト・ヤコブ病 / 神経変性疾患 / 脳 |
Research Abstract |
We previously reported an atypical sCJD-MM1 case (MM1-PL) presenting many plaque-type PrP deposits in the brain. To investigate the origin of the MM1-PL, we performed intracerebral inoculation of a brain homogenate from the MM1-PL patient into humanized mice with 129M/M or 129V/V genotype. The present our study shows that the MM1-PL was caused by the iatrogenic transmission of sCJD-VV2 prions.
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Report
(3 results)
Research Products
(14 results)