Establishment of a novel mouse model to allow efficient in vivo gene transfer into hematopoietic stem cells
| Project/Area Number |
20790676
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hematology
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| Research Institution | Kyushu University |
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Principal Investigator |
ONO Nobuyuki Kyushu University, 大学院・医学研究院, 共同研究員 (00336025)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 造血幹細胞 / 遺伝子導入 / ウイルス / マウスモデル / 免疫 / 造血細胞 |
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| Research Abstract |
In vivo gene transfer into hematopoietic stem cells (HSCs) which possess multi-potential and self-renewal capacity allows us to elucidate the function of specific genes of interest in normal hematopoiesis. In this study we sought to generate a recombinant lentivirus expressing measles virus-derived proteins to interact with human SLAM receptors,thereby serving as a novel in vivo gene transfer system for HSCs.
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Report
(3 results)
Research Products
(12 results)
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[Journal Article] CD4 T-cell autoreactivity to the mitochondrial autoantigen PDC-E2 in AMA-negative primary biliary cirrhosis.2008
Author(s)
Shimoda S, Miyakawa H, Nakamura M, Ishibashi H, Kikuchi K, Kita H, Niiro H, Arinobu Y, Ono N, Mackay IR, Gershwin ME, Akashi K
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Journal Title
J. Autoimmun. 31(2)
Pages: 110-115
Related Report
Peer Reviewed
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