| Project/Area Number |
20790712
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Infectious disease medicine
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| Research Institution | Toho University |
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Principal Investigator |
SAGA Tomoo Toho University, 医学部, 助教 (80459809)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | キノロン耐性化遺伝子 / プラスミド伝達性 / qnr / Qnr蛋白 |
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| Research Abstract |
Increase of quinolone-resistant bacteria is an important clinical problem. At the beginning of this study, I focused on the transmission and distribution of plasmid-mediated quinolone resistance determinant qnrB, which might cause rapid increase of drug resistant pathogens. Certain strains of Citrobacter species, including type strains or an isolate in pre-antibiotic era, harboured whole-length or partial qnrB-like nucleotide sequence, suggesting that qnrB might have certain relationship with this species. Not only qnrB-like gene itself but also operons neighbouring it seemed involved in stress-response system, implying the possible role of qnrB other than antimicrobial resistance.
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